UTP14A and NIN

Number of citations: 84 (PubMedID 34133714)
Data Source: BioGRID (two hybrid)

		UTP14A	NIN
Name		UTP14A small subunit processome component	ninein
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Small-subunit Processome	Pericentriolar Material Spindle Pole Nucleoplasm Nucleolus Cytoplasm Centrosome Centriole Cytoskeleton Microtubule Cytoplasmic Microtubule Plasma Membrane Axon Dendrite Ciliary Basal Body Axonal Growth Cone Apical Part Of Cell Mitotic Spindle Mitotic Spindle Pole Ciliary Transition Fiber Centriolar Subdistal Appendage
	Molecular Function	RNA Binding Protein Binding	Nucleotide Binding Calcium Ion Binding Protein Binding GTP Binding Microtubule Minus-end Binding
	Biological Process	RRNA Processing Ribosome Biogenesis	Intracellular Protein Localization Centriole-centriole Cohesion Corpus Callosum Morphogenesis Corticospinal Tract Morphogenesis Microtubule Anchoring At Centrosome Collateral Sprouting Positive Regulation Of Axonogenesis Centrosome Localization Centrosome-templated Microtubule Nucleation
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol	None
GWAS		No GWAS studies recorded	Alanine aminotransferase levels ( 33547301 34315874 ) Aspartate aminotransferase levels ( 34315874 ) Asthma (time to childhood onset) x early life tobacco smoke interaction ( 31379025 ) Cognitive performance ( 20125193 ) Diastolic blood pressure ( 30578418 ) Lupus nephritis in systemic lupus erythematosus ( 24925725 ) Mean platelet volume ( 27863252 ) Periodontal disease-related phenotype (Socransky) ( 24347629 ) Pulse pressure ( 30578418 ) Rectal cancer ( 33632709 ) Refractive error ( 32231278 ) Schizophrenia ( 33169155 ) Stroke ( 32693751 ) Systolic blood pressure ( 30578418 )
Novel Interactors		None recorded	7 novel interactors: ATL1 COCH EIF4ENIF1 L2HGDH NPTX2 SUN5 TXNDC16
Interacting Genes		54 interacting genes: AKTIP APLP1 APP ARIH2 AXIN1 BICD2 CCDC106 CCDC85B CEP70 CPE CSNK2A1 CSNK2B DLEU1 EXOSC8 GADD45G HNRNPH3 HOOK1 HOOK2 HTT KRT31 LAMTOR5 LDOC1 LMO1 LSM3 NIN NINL PDCD5 PDZK1IP1 PHF10 PRKCZ PSG1 PTEN PTPRS RABIF RGS1 RHOH RNF10 RPA2 RSRC1 SAT1 SMYD1 SNRNP48 SSR1 TERF1 TFIP11 TINAGL1 TP53 TP53BP2 TRDMT1 TXLNB USO1 VIM WDR33 ZNF24	17 interacting genes: ABI1 AUNIP AURKA BICD1 GSK3B GTSE1 KLC1 PIAS1 PRKACA PRPF6 RBM10 RTRAF SNW1 SUMO1 UBE2I UTP14A YWHAE
Entrez ID		10813	51199
HPRD ID		06712	09785
Ensembl ID		ENSG00000156697	ENSG00000100503
Uniprot IDs		Q9BVJ6	C9J066 E9PN67 Q5XUU0 Q8N4C6
PDB IDs		7MQ8 7MQ9 7MQA 7WTS	Not available
GO Terms Enriched among Interactors		FHF Complex Protein Localization To Perinuclear Region Of Cytoplasm Microtubule Cytoskeleton Organization Microtubule Anchoring At Microtubule Organizing Center HOPS Complex MRNA Metabolic Process Identical Protein Binding Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body PML Body Cellular Response To Norepinephrine Stimulus Response To Norepinephrine Cellular Localization Organelle Organization Microtubule Anchoring Early Endosome To Late Endosome Transport P53 Binding Dynein Light Intermediate Chain Binding Apoptotic Process Positive Regulation Of Aggrephagy Central Nervous System Development Cytoplasm Programmed Cell Death Cell Death Positive Regulation Of Excitatory Postsynaptic Potential Fibrillar Center Microtubule-based Process Cytoskeleton Organization Microtubule Organizing Center Intracellular Transport Nucleus Cytoskeleton-dependent Intracellular Transport G-rich Strand Telomeric DNA Binding Cellular Response To Muramyl Dipeptide Modulation Of Excitatory Postsynaptic Potential Developmental Cell Growth Microtubule Anchoring At Centrosome Regulation Of Nervous System Process Endosome To Lysosome Transport Nuclear Matrix Supramolecular Fiber Organization Negative Regulation Of DNA Metabolic Process Negative Regulation Of Cell Cycle Negative Regulation Of Neurogenesis Centrosome Nucleoplasm Dynactin Binding Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Nervous System Development Cytoplasmic Microtubule Organization	Regulation Of Nucleocytoplasmic Transport Nuclear Speck Ubiquitin Protein Ligase Binding Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Glutamatergic Synapse Presynaptic Cytosol Postsynaptic Cytosol Regulation Of Protein Export From Nucleus Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Small Protein Activating Enzyme Binding PML Body Centrosome Peptidyl-serine Phosphorylation Regulation Of Intracellular Transport Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Protein Localization To Centrosome Regulation Of Intracellular Protein Transport Cellular Response To Heat Protein Sumoylation Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Processing Regulation Of Protein Localization To Centrosome RNA Binding Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Protein Localization To Organelle Dynactin Binding Positive Regulation Of Protein Catabolic Process Enzyme Binding Response To Heat Positive Regulation Of Intracellular Protein Transport Intracellular Potassium Ion Homeostasis Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Localization Transcription Factor Binding SUMO Transferase Activity Membraneless Organelle Assembly Cytoskeleton Negative Regulation Of Metabolic Process Regulation Of Cellular Localization Protein Serine/threonine/tyrosine Kinase Activity Regulation Of Protein Metabolic Process Nuclear Export Negative Regulation Of Nucleobase-containing Compound Metabolic Process