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PTPRC and CD22
Number of citations of the paper that reports this interaction (PubMedID
7537381
)
30
Data Source:
HPRD
(in vivo)
PTPRC
CD22
Description
protein tyrosine phosphatase receptor type C
CD22 molecule
Image
GO Annotations
Cellular Component
Plasma Membrane
Focal Adhesion
External Side Of Plasma Membrane
Cytoplasmic Side Of Plasma Membrane
Cell Surface
Membrane
Secretory Granule Membrane
Bleb
Membrane Raft
Synapse
Extracellular Exosome
Cell Periphery
Side Of Membrane
Membrane Microdomain
Cytoplasm
Early Endosome
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Membrane
Neuronal Cell Body Membrane
Recycling Endosome
Extracellular Exosome
Molecular Function
Phosphoprotein Phosphatase Activity
Protein Tyrosine Phosphatase Activity
Transmembrane Receptor Protein Tyrosine Phosphatase Activity
Signaling Receptor Binding
Protein Binding
Heparin Binding
Hydrolase Activity
Protein Kinase Binding
Protein Tyrosine Kinase Inhibitor Activity
Ankyrin Binding
Spectrin Binding
Heparan Sulfate Proteoglycan Binding
IgM Binding
Signaling Receptor Binding
Protein Binding
Protein Phosphatase Binding
Carbohydrate Binding
Sialic Acid Binding
CD4 Receptor Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
Natural Killer Cell Differentiation
Negative Regulation Of T Cell Mediated Cytotoxicity
Positive Regulation Of T Cell Mediated Cytotoxicity
Negative Regulation Of Cytokine-mediated Signaling Pathway
Hematopoietic Progenitor Cell Differentiation
Positive Regulation Of Immunoglobulin Production
Positive Regulation Of T Cell Mediated Immunity
Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin
Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin
Negative Regulation Of Protein Kinase Activity
Protein Dephosphorylation
Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration
Leukocyte Cell-cell Adhesion
Signal Transduction
Cell Surface Receptor Signaling Pathway
Response To Gamma Radiation
Regulation Of Gene Expression
Dephosphorylation
B Cell Differentiation
T Cell Differentiation
Positive Regulation Of B Cell Proliferation
Regulation Of Interleukin-8 Production
Negative Regulation Of Interleukin-2 Production
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Tumor Necrosis Factor Production
Heterotypic Cell-cell Adhesion
T Cell Proliferation
B Cell Proliferation
Positive Regulation Of T Cell Proliferation
T Cell Activation
Gamma-delta T Cell Differentiation
Positive Regulation Of MAPK Cascade
Cell Cycle Phase Transition
Plasma Membrane Raft Distribution
Positive Thymic T Cell Selection
Negative Thymic T Cell Selection
Positive Regulation Of T Cell Differentiation
Positive Regulation Of Gamma-delta T Cell Differentiation
Positive Regulation Of Protein Kinase Activity
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Alpha-beta T Cell Proliferation
Positive Regulation Of Alpha-beta T Cell Proliferation
Positive Regulation Of Isotype Switching To IgG Isotypes
Bone Marrow Development
Stem Cell Development
Regulation Of Phagocytosis
Positive Regulation Of Phagocytosis
Positive Regulation Of Calcium-mediated Signaling
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Regulation Of T Cell Receptor Signaling Pathway
Positive Regulation Of Antigen Receptor-mediated Signaling Pathway
Release Of Sequestered Calcium Ion Into Cytosol
Defense Response To Virus
Regulation Of Cell Cycle
Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Interleukin-4-mediated Signaling Pathway
Negative Regulation Of Microglial Cell Activation
Response To Aldosterone
DN2 Thymocyte Differentiation
Positive Regulation Of Hematopoietic Stem Cell Migration
Positive Regulation Of Stem Cell Proliferation
Regulation Of Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Immunoglobulin Production
Negative Regulation Of Immune System Process
Cell Adhesion
Negative Regulation Of Signal Transduction
Regulation Of Endocytosis
Regulation Of B Cell Proliferation
B Cell Activation
Regulation Of Immune Response
Negative Regulation Of Calcium-mediated Signaling
Negative Regulation Of B Cell Receptor Signaling Pathway
Pathways
Phosphorylation of CD3 and TCR zeta chains
Other semaphorin interactions
Neutrophil degranulation
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
CD22 mediated BCR regulation
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Epratuzumab
Inotuzumab ozogamicin
Moxetumomab pasudotox
Diseases
T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS
Apolipoprotein B levels (
32203549
)
Aspartate aminotransferase levels (
33547301
)
Asthma (
31959851
34103634
32296059
31619474
30929738
)
Asthma (adult onset) (
30929738
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Crohn's disease (
28067908
26192919
)
Eosinophil count (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Inflammatory bowel disease (
26192919
)
LDL cholesterol levels (
32203549
)
Lymphocyte count (
27863252
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Mean corpuscular hemoglobin (
20139978
29403010
28017375
)
Mean corpuscular hemoglobin concentration (
29403010
)
Mean corpuscular volume (
29403010
32888494
)
Mean platelet volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Medication use (adrenergics, inhalants) (
31015401
)
Monocyte percentage of white cells (
32888494
)
Plateletcrit (
32888494
)
Red blood cell count (
29403010
32888494
)
Refractive error (
32231278
)
Rheumatoid arthritis (ACPA-positive) (
24532676
)
Sum eosinophil basophil counts (
27863252
)
Systemic lupus erythematosus (
27399966
33272962
)
Type 1 diabetes (
34012112
)
Ulcerative colitis (
24837172
)
Vitiligo (
27723757
)
White blood cell count (
32888494
)
Red cell distribution width (
32888494
)
Interacting Genes
45 interacting genes:
ANP32A
CD1D
CD2
CD22
CD247
CD28
CD4
CD8A
CSNK2A1
CSNK2A2
CXCR4
DPP4
EZR
FCGR3A
FYN
GANAB
GRB2
IFNAR1
INSR
IRS1
ITGAL
JAK1
JAK2
JAK3
LCK
LCP2
LGALS1
LSM1
LYN
MAPK1
MBL2
PAEP
PPFIA1
PPFIBP2
PRKCSH
PTPN6
PTPRCAP
RASA1
RNF11
SEMA4D
SKAP1
SRC
TYK2
UHRF2
ZAP70
21 interacting genes:
ANKRD46
AP2M1
ATP2B4
CD19
CFTR
GRB2
HP
IGHM
INPP5D
LCP2
LYN
MTDH
NTAQ1
PIK3R1
PLCG1
PTPN6
PTPRC
SHC1
ST6GAL1
SYK
TMEM140
Entrez ID
5788
933
HPRD ID
01050
00114
Ensembl ID
ENSG00000081237
ENSG00000012124
Uniprot IDs
M9MML4
P08575
P20273
Q0EAF5
PDB IDs
1YGR
1YGU
5FMV
5FN6
5FN7
8VSE
5VKJ
5VKM
5VL3
7O52
Enriched GO Terms of Interacting Partners
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Leukocyte Activation
Cell Surface Receptor Signaling Pathway
Lymphocyte Activation
Cell Activation
Regulation Of Immune Response
Positive Regulation Of Cell-cell Adhesion
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Lymphocyte Activation
T Cell Costimulation
Regulation Of Leukocyte Cell-cell Adhesion
Regulation Of T Cell Activation
Positive Regulation Of Cell Activation
Positive Regulation Of Immune System Process
Positive Regulation Of Lymphocyte Activation
Positive Regulation Of Leukocyte Cell-cell Adhesion
Positive Regulation Of Immune Response
Immune System Process
Regulation Of Cell-cell Adhesion
Antigen Receptor-mediated Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Cell Adhesion
Positive Regulation Of T Cell Activation
Regulation Of Cell Activation
Regulation Of Immune System Process
Non-membrane Spanning Protein Tyrosine Kinase Activity
Immune Response-regulating Signaling Pathway
Positive Regulation Of Cell Adhesion
Immune Response-activating Signaling Pathway
Immune Response
Activation Of Immune Response
T Cell Activation
Signal Transduction
Enzyme-linked Receptor Protein Signaling Pathway
T Cell Receptor Signaling Pathway
Phosphotyrosine Residue Binding
Peptidyl-tyrosine Phosphorylation
Protein Tyrosine Kinase Activity
Fc-gamma Receptor Signaling Pathway
Positive Regulation Of Multicellular Organismal Process
Protein Kinase Activity
Protein Phosphorylation
Regulation Of Leukocyte Proliferation
Phosphorylation
Immune Effector Process
Signaling Receptor Binding
Lymphocyte Differentiation
Regulation Of Mononuclear Cell Proliferation
Fc Receptor Signaling Pathway
Mononuclear Cell Differentiation
Antigen Receptor-mediated Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune Response-activating Signaling Pathway
Immune Response-regulating Signaling Pathway
Activation Of Immune Response
Neurotrophin TRKA Receptor Binding
Positive Regulation Of Immune Response
Phosphotyrosine Residue Binding
Regulation Of Immune Response
Negative Regulation Of Immune Response
Positive Regulation Of Immune System Process
Regulation Of B Cell Activation
Negative Regulation Of Defense Response
Cell Surface Receptor Signaling Pathway
Negative Regulation Of Immune System Process
Natural Killer Cell Mediated Cytotoxicity
Regulation Of Multicellular Organismal Development
Leukocyte Activation
T Cell Receptor Signaling Pathway
Natural Killer Cell Mediated Immunity
Response To Other Organism
Immune Effector Process
Lymphocyte Mediated Immunity
Immune System Process
Regulation Of Sequestering Of Calcium Ion
Cell Activation
Regulation Of Immune System Process
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Leukocyte Mediated Immunity
Lymphocyte Activation
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Regulation Of Monoatomic Ion Transmembrane Transport
Response To External Biotic Stimulus
Defense Response
Regulation Of Lymphocyte Activation
Intracellular Signal Transduction
Leukocyte Mediated Cytotoxicity
Negative Regulation Of Inflammatory Response
Positive Regulation Of Lymphocyte Activation
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
B Cell Activation
Regulation Of B Cell Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Regulation Of Defense Response
Membrane Raft
Immune Response
Ephrin Receptor Binding
Positive Regulation Of Cell Activation
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