CD22 and HP

Number of citations of the paper that reports this interaction (PubMedID 11967116)
0

Data Source:
HPRD (in vivo)

		CD22	HP
Description		CD22 molecule	haptoglobin
Image
GO Annotations	Cellular Component	Cytoplasm Early Endosome Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Neuronal Cell Body Membrane Recycling Endosome Extracellular Exosome	Extracellular Region Extracellular Space Haptoglobin-hemoglobin Complex Specific Granule Lumen Extracellular Exosome Endocytic Vesicle Lumen Blood Microparticle Tertiary Granule Lumen
	Molecular Function	IgM Binding Signaling Receptor Binding Protein Binding Protein Phosphatase Binding Carbohydrate Binding Sialic Acid Binding CD4 Receptor Binding	Serine-type Endopeptidase Activity Protein Binding Antioxidant Activity Hemoglobin Binding
	Biological Process	Negative Regulation Of Immunoglobulin Production Negative Regulation Of Immune System Process Cell Adhesion Negative Regulation Of Signal Transduction Regulation Of Endocytosis Regulation Of B Cell Proliferation B Cell Activation Regulation Of Immune Response Negative Regulation Of Calcium-mediated Signaling Negative Regulation Of B Cell Receptor Signaling Pathway	Immune System Process Defense Response Acute-phase Response Inflammatory Response Zymogen Activation Response To Hydrogen Peroxide Defense Response To Bacterium Cellular Oxidant Detoxification Negative Regulation Of Hydrogen Peroxide Catabolic Process
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell CD22 mediated BCR regulation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Scavenging of heme from plasma Neutrophil degranulation
Drugs		Epratuzumab Inotuzumab ozogamicin Moxetumomab pasudotox	Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Red cell distribution width ( 32888494)	Cholesterol, total ( 20686565 25961943) Haptoglobin levels ( 22403646) Hemoglobin levels ( 32327693) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) LDL cholesterol ( 20686565 25961943) Lipoprotein (a) levels ( 33730874) Low density lipoprotein cholesterol levels ( 29403010) Metabolite levels ( 22916037) Morning person ( 30696823) Parental lifespan ( 30642433) Plasma haptoglobin levels in type 2 diabetes ( 29572449) Total cholesterol levels ( 29403010 33339817) Urinary haptoglobin levels in type 2 diabetes ( 29572449)
Interacting Genes		21 interacting genes: ANKRD46 AP2M1 ATP2B4 CD19 CFTR GRB2 HP IGHM INPP5D LCP2 LYN MTDH NTAQ1 PIK3R1 PLCG1 PTPN6 PTPRC SHC1 ST6GAL1 SYK TMEM140	21 interacting genes: ADAMTS4 ATP7B C1RL CD163 CD22 GADD45G GRB2 HBB HSP90AA1 ITGAM ITGB2 LAMC3 MVP RBBP6 RPL11 SMAD3 TBL1X TGM2 TP63 VKORC1 WASL
Entrez ID		933	3240
HPRD ID		00114	00772
Ensembl ID		ENSG00000012124	ENSG00000257017
Uniprot IDs		P20273 Q0EAF5	A0A0C4DGL8 P00738 Q6PEJ8
PDB IDs		5VKJ 5VKM 5VL3 7O52	4WJG 4X0L 5HU6 6TB2 8XMP 8XMQ 8XMW 9FHB 9FMU
Enriched GO Terms of Interacting Partners?		Antigen Receptor-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway B Cell Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Neurotrophin TRKA Receptor Binding Positive Regulation Of Immune Response Phosphotyrosine Residue Binding Regulation Of Immune Response Negative Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of B Cell Activation Negative Regulation Of Defense Response Cell Surface Receptor Signaling Pathway Negative Regulation Of Immune System Process Natural Killer Cell Mediated Cytotoxicity Regulation Of Multicellular Organismal Development Leukocyte Activation T Cell Receptor Signaling Pathway Natural Killer Cell Mediated Immunity Response To Other Organism Immune Effector Process Lymphocyte Mediated Immunity Immune System Process Regulation Of Sequestering Of Calcium Ion Cell Activation Regulation Of Immune System Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Leukocyte Mediated Immunity Lymphocyte Activation Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Monoatomic Ion Transmembrane Transport Response To External Biotic Stimulus Defense Response Regulation Of Lymphocyte Activation Intracellular Signal Transduction Leukocyte Mediated Cytotoxicity Negative Regulation Of Inflammatory Response Positive Regulation Of Lymphocyte Activation Regulation Of Release Of Sequestered Calcium Ion Into Cytosol B Cell Activation Regulation Of B Cell Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Defense Response Membrane Raft Immune Response Ephrin Receptor Binding Positive Regulation Of Cell Activation	Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Integrin AlphaM-beta2 Complex Protein Phosphatase Binding Positive Regulation Of Neutrophil Degranulation Extracellular Exosome Negative Regulation Of Dopamine Metabolic Process Negative Regulation Of Catecholamine Metabolic Process Regulation Of Neutrophil Degranulation Positive Regulation Of Reactive Oxygen Species Metabolic Process Complement Component C3b Binding Regulation Of Immune Response Protein Kinase Binding Protein Stabilization Protein Metabolic Process Endocytic Vesicle Lumen Response To Other Organism Regulation Of Dopamine Metabolic Process Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Anion Generation Regulation Of Immune System Process Regulation Of Vesicle-mediated Transport Response To Stress Ficolin-1-rich Granule Lumen Cargo Receptor Activity Positive Regulation Of Protein Targeting To Membrane Amyloid-beta Clearance Leukocyte Activation Integrin Complex Positive Regulation Of Multicellular Organismal Process Regulation Of Reactive Oxygen Species Metabolic Process Morphogenesis Of An Epithelium Positive Regulation Of Establishment Of Protein Localization Microglial Cell Activation Regulation Of Superoxide Metabolic Process Phagocytosis, Engulfment Response To External Biotic Stimulus Regulation Of Protein Targeting To Membrane Leukocyte Activation Involved In Inflammatory Response External Side Of Plasma Membrane Cell Activation Positive Regulation Of Immune Response Positive Regulation Of Metabolic Process Guanyl-nucleotide Exchange Factor Adaptor Activity Defense Response Endodermal Cell Differentiation Receptor-mediated Endocytosis Response To Cocaine
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