PTPRC and TYK2

Number of citations of the paper that reports this interaction (PubMedID 11201744)
0

Data Source:
HPRD (in vitro)

		PTPRC	TYK2
Description		protein tyrosine phosphatase receptor type C	tyrosine kinase 2
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GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Cell Surface Membrane Secretory Granule Membrane Bleb Membrane Raft Synapse Extracellular Exosome Cell Periphery Side Of Membrane Membrane Microdomain	Nucleus Cytoplasm Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Extrinsic Component Of Plasma Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Interleukin-12 Receptor Complex Receptor Complex Extracellular Exosome Interleukin-23 Receptor Complex
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Signaling Receptor Binding Protein Binding Heparin Binding Hydrolase Activity Protein Kinase Binding Protein Tyrosine Kinase Inhibitor Activity Ankyrin Binding Spectrin Binding Heparan Sulfate Proteoglycan Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Growth Hormone Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Natural Killer Cell Differentiation Negative Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Cytotoxicity Negative Regulation Of Cytokine-mediated Signaling Pathway Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Immunoglobulin Production Positive Regulation Of T Cell Mediated Immunity Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Negative Regulation Of Protein Kinase Activity Protein Dephosphorylation Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Leukocyte Cell-cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway Response To Gamma Radiation Regulation Of Gene Expression Dephosphorylation B Cell Differentiation T Cell Differentiation Positive Regulation Of B Cell Proliferation Regulation Of Interleukin-8 Production Negative Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion T Cell Proliferation B Cell Proliferation Positive Regulation Of T Cell Proliferation T Cell Activation Gamma-delta T Cell Differentiation Positive Regulation Of MAPK Cascade Cell Cycle Phase Transition Plasma Membrane Raft Distribution Positive Thymic T Cell Selection Negative Thymic T Cell Selection Positive Regulation Of T Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Protein Kinase Activity Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Alpha-beta T Cell Proliferation Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Isotype Switching To IgG Isotypes Bone Marrow Development Stem Cell Development Regulation Of Phagocytosis Positive Regulation Of Phagocytosis Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol Defense Response To Virus Regulation Of Cell Cycle Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Interleukin-4-mediated Signaling Pathway Negative Regulation Of Microglial Cell Activation Response To Aldosterone DN2 Thymocyte Differentiation Positive Regulation Of Hematopoietic Stem Cell Migration Positive Regulation Of Stem Cell Proliferation Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Immune Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Population Proliferation Cytokine-mediated Signaling Pathway Regulation Of Cell-cell Adhesion Cell Differentiation Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Proliferation Intracellular Signal Transduction Interleukin-12-mediated Signaling Pathway Interleukin-23-mediated Signaling Pathway Type III Interferon-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Alpha-beta T Cell Activation Positive Regulation Of NK T Cell Proliferation Type II Interferon-mediated Signaling Pathway Type I Interferon-mediated Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cellular Response To Virus Interleukin-10-mediated Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of T-helper 17 Type Immune Response
Pathways		Phosphorylation of CD3 and TCR zeta chains Other semaphorin interactions Neutrophil degranulation	Interleukin-6 signaling Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation Other interleukin signaling Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling IL-6-type cytokine receptor ligand interactions Interleukin-20 family signaling Interleukin-35 Signalling Interleukin-12 signaling Interleukin-12 signaling Interleukin-23 signaling Interleukin-23 signaling Interleukin-27 signaling Interleukin-27 signaling Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Regulation of IFNA/IFNB signaling Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Potential therapeutics for SARS Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses Signaling by ALK fusions and activated point mutants Evasion by RSV of host interferon responses
Drugs			2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one Ruxolitinib Tofacitinib Baricitinib Fostamatinib Abrocitinib Deucravacitinib
Diseases		T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma	Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS		Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Asthma ( 31959851 34103634 32296059 31619474 30929738) Asthma (adult onset) ( 30929738) Celiac disease and Rheumatoid arthritis ( 26546613) Crohn's disease ( 28067908 26192919) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Inflammatory bowel disease ( 26192919) LDL cholesterol levels ( 32203549) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 20139978 29403010 28017375) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 29403010 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Monocyte percentage of white cells ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 29403010 32888494) Refractive error ( 32231278) Rheumatoid arthritis (ACPA-positive) ( 24532676) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 33272962) Type 1 diabetes ( 34012112) Ulcerative colitis ( 24837172) Vitiligo ( 27723757) White blood cell count ( 32888494)	Ankylosing spondylitis ( 23749187) Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) COVID-19 (critical illness vs population) ( 33307546) Crohn's disease ( 21102463 28067908) Inflammatory bowel disease ( 28067908 23128233) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 24076602 31604244 21833088) Neutrophil percentage of white cells ( 32888494 27863252) Pediatric autoimmune diseases ( 26301688) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494) Primary biliary cholangitis ( 26394269) Primary biliary cirrhosis ( 22961000) Psoriasis ( 20953190 23143594) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624) Rheumatoid arthritis ( 23143596 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Sarcoidosis ( 26051272) Systemic lupus erythematosus ( 27399966 33272962 26502338 28714469) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Type 1 diabetes ( 21829393 19966805 32005708 25751624) Voxel-wise structural brain imaging measurements in Alzheimer’s disease ( 30584014)
Interacting Genes		45 interacting genes: ANP32A CD1D CD2 CD22 CD247 CD28 CD4 CD8A CSNK2A1 CSNK2A2 CXCR4 DPP4 EZR FCGR3A FYN GANAB GRB2 IFNAR1 INSR IRS1 ITGAL JAK1 JAK2 JAK3 LCK LCP2 LGALS1 LSM1 LYN MAPK1 MBL2 PAEP PPFIA1 PPFIBP2 PRKCSH PTPN6 PTPRCAP RASA1 RNF11 SEMA4D SKAP1 SRC TYK2 UHRF2 ZAP70	44 interacting genes: CBL COPS5 CRKL CYSRT1 DNM2 EIF2AK2 FHL3 FYN GHR GOLGA6L9 HNRNPK IFNAR1 IFNAR2 IL13RA1 IL6ST IRS1 IRS2 JAK1 JAKMIP1 KHDRBS2 KHDRBS3 KRT31 KRT40 KRTAP6-3 LYN PDGFRB PIK3R1 PLAUR PRDM5 PRMT5 PTAFR PTPN1 PTPN6 PTPRC RACK1 SOCS1 STAM2 STAT1 STAT2 TK1 TP53BP2 TRAF4 VAV1 XRCC5
Entrez ID		5788	7297
HPRD ID		01050	01490
Ensembl ID		ENSG00000081237	ENSG00000105397
Uniprot IDs		M9MML4 P08575	A0A8V8TN50 A0A8V8TPX5 H0YCT7 H0YE24 P29597
PDB IDs		1YGR 1YGU 5FMV 5FN6 5FN7 8VSE	3LXN 3LXP 3NYX 3NZ0 3ZON 4GFO 4GIH 4GII 4GJ2 4GJ3 4GVJ 4OLI 4PO6 4PY1 4WOV 5C01 5C03 5F1Z 5F20 5TKD 5WAL 6AAM 6DBK 6DBM 6NSL 6NZE 6NZF 6NZH 6NZP 6NZQ 6NZR 6OVA 6VNS 6VNV 6VNX 6VNY 6X8F 6X8G 7AX4 7K7O 7K7Q 7UYR 7UYS 7UYT 7UYU 8EXN 8EYC 8S98 8S99 8S9A 8TB5 8TB6
Enriched GO Terms of Interacting Partners?		Leukocyte Activation Cell Surface Receptor Signaling Pathway Lymphocyte Activation Cell Activation Regulation Of Immune Response Positive Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Lymphocyte Activation T Cell Costimulation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Regulation Of Immune System Process Positive Regulation Of Lymphocyte Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Immune Response Immune System Process Regulation Of Cell-cell Adhesion Antigen Receptor-mediated Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Adhesion Positive Regulation Of T Cell Activation Regulation Of Cell Activation Regulation Of Immune System Process Non-membrane Spanning Protein Tyrosine Kinase Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Cell Adhesion Immune Response-activating Signaling Pathway Immune Response Activation Of Immune Response T Cell Activation Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway T Cell Receptor Signaling Pathway Phosphotyrosine Residue Binding Peptidyl-tyrosine Phosphorylation Protein Tyrosine Kinase Activity Fc-gamma Receptor Signaling Pathway Positive Regulation Of Multicellular Organismal Process Protein Kinase Activity Protein Phosphorylation Regulation Of Leukocyte Proliferation Phosphorylation Immune Effector Process Signaling Receptor Binding Lymphocyte Differentiation Regulation Of Mononuclear Cell Proliferation Fc Receptor Signaling Pathway Mononuclear Cell Differentiation	Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of Signal Transduction Phosphotyrosine Residue Binding Growth Hormone Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Programmed Cell Death Positive Regulation Of Multicellular Organismal Process SH3 Domain Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Receptor Signaling Pathway Via JAK-STAT Growth Hormone Receptor Signaling Pathway Via JAK-STAT Receptor Complex SH2 Domain Binding Response To External Biotic Stimulus Cytokine Binding Phosphatidylinositol 3-kinase Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Enzyme Binding Response To Peptide Hormone Regulation Of Signaling Regulation Of Cell Communication Enzyme-linked Receptor Protein Signaling Pathway Signal Transduction Cytosol Regulation Of MAPK Cascade Cellular Response To Insulin Stimulus Cellular Response To Platelet-derived Growth Factor Stimulus Regulation Of Cell Adhesion Type I Interferon-mediated Signaling Pathway Response To Other Organism Response To Insulin Insulin Receptor Binding Positive Regulation Of Cell-cell Adhesion Response To Platelet-derived Growth Factor Regulation Of Defense Response Protein Kinase Binding Phosphatidylinositol 3-kinase Activator Activity Cellular Response To Peptide Hormone Stimulus Lymphocyte Proliferation Ephrin Receptor Binding Mononuclear Cell Proliferation Regulation Of Macromolecule Biosynthetic Process
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