Wiki-Pi
About
Search
People
Updates
Search
PTPRC and IFNAR1
Number of citations of the paper that reports this interaction (PubMedID
9403695
)
0
Data Source:
HPRD
(in vitro, in vivo)
PTPRC
IFNAR1
Description
protein tyrosine phosphatase receptor type C
interferon alpha and beta receptor subunit 1
Image
GO Annotations
Cellular Component
Plasma Membrane
Focal Adhesion
External Side Of Plasma Membrane
Cytoplasmic Side Of Plasma Membrane
Cell Surface
Membrane
Secretory Granule Membrane
Bleb
Membrane Raft
Synapse
Extracellular Exosome
Cell Periphery
Side Of Membrane
Membrane Microdomain
Lysosome
Endosome
Late Endosome
Plasma Membrane
Membrane
Receptor Complex
Molecular Function
Phosphoprotein Phosphatase Activity
Protein Tyrosine Phosphatase Activity
Transmembrane Receptor Protein Tyrosine Phosphatase Activity
Signaling Receptor Binding
Protein Binding
Heparin Binding
Hydrolase Activity
Protein Kinase Binding
Protein Tyrosine Kinase Inhibitor Activity
Ankyrin Binding
Spectrin Binding
Heparan Sulfate Proteoglycan Binding
Interferon Receptor Activity
Type I Interferon Receptor Activity
Protein Binding
JAK Pathway Signal Transduction Adaptor Activity
Cytokine Binding
Type I Interferon Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
Natural Killer Cell Differentiation
Negative Regulation Of T Cell Mediated Cytotoxicity
Positive Regulation Of T Cell Mediated Cytotoxicity
Negative Regulation Of Cytokine-mediated Signaling Pathway
Hematopoietic Progenitor Cell Differentiation
Positive Regulation Of Immunoglobulin Production
Positive Regulation Of T Cell Mediated Immunity
Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin
Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin
Negative Regulation Of Protein Kinase Activity
Protein Dephosphorylation
Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration
Leukocyte Cell-cell Adhesion
Signal Transduction
Cell Surface Receptor Signaling Pathway
Response To Gamma Radiation
Regulation Of Gene Expression
Dephosphorylation
B Cell Differentiation
T Cell Differentiation
Positive Regulation Of B Cell Proliferation
Regulation Of Interleukin-8 Production
Negative Regulation Of Interleukin-2 Production
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Tumor Necrosis Factor Production
Heterotypic Cell-cell Adhesion
T Cell Proliferation
B Cell Proliferation
Positive Regulation Of T Cell Proliferation
T Cell Activation
Gamma-delta T Cell Differentiation
Positive Regulation Of MAPK Cascade
Cell Cycle Phase Transition
Plasma Membrane Raft Distribution
Positive Thymic T Cell Selection
Negative Thymic T Cell Selection
Positive Regulation Of T Cell Differentiation
Positive Regulation Of Gamma-delta T Cell Differentiation
Positive Regulation Of Protein Kinase Activity
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Alpha-beta T Cell Proliferation
Positive Regulation Of Alpha-beta T Cell Proliferation
Positive Regulation Of Isotype Switching To IgG Isotypes
Bone Marrow Development
Stem Cell Development
Regulation Of Phagocytosis
Positive Regulation Of Phagocytosis
Positive Regulation Of Calcium-mediated Signaling
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Regulation Of T Cell Receptor Signaling Pathway
Positive Regulation Of Antigen Receptor-mediated Signaling Pathway
Release Of Sequestered Calcium Ion Into Cytosol
Defense Response To Virus
Regulation Of Cell Cycle
Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Interleukin-4-mediated Signaling Pathway
Negative Regulation Of Microglial Cell Activation
Response To Aldosterone
DN2 Thymocyte Differentiation
Positive Regulation Of Hematopoietic Stem Cell Migration
Positive Regulation Of Stem Cell Proliferation
Regulation Of Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Regulation Of Transcription By RNA Polymerase II
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Response To Virus
Positive Regulation Of Metabolic Process
Cytokine-mediated Signaling Pathway
Response To Lipopolysaccharide
Cellular Response To Interferon-alpha
Cellular Response To Interferon-beta
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Type I Interferon-mediated Signaling Pathway
Cellular Response To Virus
Positive Regulation Of Protein Localization To Nucleus
Positive Regulation Of Cellular Respiration
Pathways
Phosphorylation of CD3 and TCR zeta chains
Other semaphorin interactions
Neutrophil degranulation
Interferon alpha/beta signaling
Regulation of IFNA/IFNB signaling
Regulation of IFNA/IFNB signaling
Potential therapeutics for SARS
SARS-CoV-2 activates/modulates innate and adaptive immune responses
Evasion by RSV of host interferon responses
Drugs
Peginterferon alfa-2a
Interferon alfa-n1
Interferon alfa-n3
Peginterferon alfa-2b
Interferon alfa-2a
Interferon beta-1a
Interferon beta-1b
Interferon alfacon-1
Interferon alfa-2b
Interferon alfa
Human interferon omega-1
Peginterferon beta-1a
Anifrolumab
Human interferon beta
Ropeginterferon alfa-2b
Diseases
T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS
Apolipoprotein B levels (
32203549
)
Aspartate aminotransferase levels (
33547301
)
Asthma (
31959851
34103634
32296059
31619474
30929738
)
Asthma (adult onset) (
30929738
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Crohn's disease (
28067908
26192919
)
Eosinophil count (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Inflammatory bowel disease (
26192919
)
LDL cholesterol levels (
32203549
)
Lymphocyte count (
27863252
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Mean corpuscular hemoglobin (
20139978
29403010
28017375
)
Mean corpuscular hemoglobin concentration (
29403010
)
Mean corpuscular volume (
29403010
32888494
)
Mean platelet volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Medication use (adrenergics, inhalants) (
31015401
)
Monocyte percentage of white cells (
32888494
)
Plateletcrit (
32888494
)
Red blood cell count (
29403010
32888494
)
Refractive error (
32231278
)
Rheumatoid arthritis (ACPA-positive) (
24532676
)
Sum eosinophil basophil counts (
27863252
)
Systemic lupus erythematosus (
27399966
33272962
)
Type 1 diabetes (
34012112
)
Ulcerative colitis (
24837172
)
Vitiligo (
27723757
)
White blood cell count (
32888494
)
Blood protein levels (
30072576
)
Crohn's disease (
23128233
)
Psoriasis (
25903422
)
Interacting Genes
45 interacting genes:
ANP32A
CD1D
CD2
CD22
CD247
CD28
CD4
CD8A
CSNK2A1
CSNK2A2
CXCR4
DPP4
EZR
FCGR3A
FYN
GANAB
GRB2
IFNAR1
INSR
IRS1
ITGAL
JAK1
JAK2
JAK3
LCK
LCP2
LGALS1
LSM1
LYN
MAPK1
MBL2
PAEP
PPFIA1
PPFIBP2
PRKCSH
PTPN6
PTPRCAP
RASA1
RNF11
SEMA4D
SKAP1
SRC
TYK2
UHRF2
ZAP70
26 interacting genes:
BRCC3
CRKL
FBXW11
IFNA1
IFNA2
IFNAR2
IFNB1
IFNW1
LAPTM4B
LCK
LRPAP1
MAPK1
PIK3R1
PRKACA
PRKD2
PRMT1
PTPN11
PTPN6
PTPRC
RACK1
SOCS1
STAT2
STAT3
TYK2
USP7
ZAP70
Entrez ID
5788
3454
HPRD ID
01050
00126
Ensembl ID
ENSG00000081237
ENSG00000142166
Uniprot IDs
M9MML4
P08575
A0A8V8TQK8
A0A994J6F6
P17181
PDB IDs
1YGR
1YGU
5FMV
5FN6
5FN7
8VSE
3S98
3SE3
3SE4
4PO6
8Y31
Enriched GO Terms of Interacting Partners
?
Leukocyte Activation
Cell Surface Receptor Signaling Pathway
Lymphocyte Activation
Cell Activation
Regulation Of Immune Response
Positive Regulation Of Cell-cell Adhesion
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Lymphocyte Activation
T Cell Costimulation
Regulation Of Leukocyte Cell-cell Adhesion
Regulation Of T Cell Activation
Positive Regulation Of Cell Activation
Positive Regulation Of Immune System Process
Positive Regulation Of Lymphocyte Activation
Positive Regulation Of Leukocyte Cell-cell Adhesion
Positive Regulation Of Immune Response
Immune System Process
Regulation Of Cell-cell Adhesion
Antigen Receptor-mediated Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Cell Adhesion
Positive Regulation Of T Cell Activation
Regulation Of Cell Activation
Regulation Of Immune System Process
Non-membrane Spanning Protein Tyrosine Kinase Activity
Immune Response-regulating Signaling Pathway
Positive Regulation Of Cell Adhesion
Immune Response-activating Signaling Pathway
Immune Response
Activation Of Immune Response
T Cell Activation
Signal Transduction
Enzyme-linked Receptor Protein Signaling Pathway
T Cell Receptor Signaling Pathway
Phosphotyrosine Residue Binding
Peptidyl-tyrosine Phosphorylation
Protein Tyrosine Kinase Activity
Fc-gamma Receptor Signaling Pathway
Positive Regulation Of Multicellular Organismal Process
Protein Kinase Activity
Protein Phosphorylation
Regulation Of Leukocyte Proliferation
Phosphorylation
Immune Effector Process
Signaling Receptor Binding
Lymphocyte Differentiation
Regulation Of Mononuclear Cell Proliferation
Fc Receptor Signaling Pathway
Mononuclear Cell Differentiation
Cytokine-mediated Signaling Pathway
Cell Surface Receptor Signaling Pathway
Phosphotyrosine Residue Binding
Regulation Of Signal Transduction
Type I Interferon-mediated Signaling Pathway
Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Interferon-mediated Signaling Pathway
Cell Surface Receptor Signaling Pathway Via STAT
Regulation Of Immune System Process
T Cell Receptor Signaling Pathway
Regulation Of Immune Response
Cytokine Receptor Binding
Regulation Of Hemopoiesis
T Cell Activation
Positive Regulation Of Cell Communication
Intracellular Signal Transduction
Positive Regulation Of Signaling
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Regulation Of Cell Adhesion
Type I Interferon Receptor Binding
Regulation Of Cytokine Production
Cellular Response To Virus
Positive Regulation Of Signal Transduction
Protein Modification Process
Natural Killer Cell Activation Involved In Immune Response
Antigen Receptor-mediated Signaling Pathway
Leukocyte Activation Involved In Immune Response
Positive Regulation Of Intracellular Signal Transduction
Response To Exogenous DsRNA
Regulation Of Intracellular Signal Transduction
Cell Activation Involved In Immune Response
Regulation Of Leukocyte Cell-cell Adhesion
Regulation Of T Cell Activation
Regulation Of Developmental Process
Leukocyte Activation
Response To DsRNA
Positive Regulation Of Immune System Process
B Cell Activation
Regulation Of Multicellular Organismal Process
Immune System Process
Lymphocyte Activation
Natural Killer Cell Activation
Cell Activation
Phosphate-containing Compound Metabolic Process
Negative Regulation Of Cytokine Production
Regulation Of Lymphocyte Differentiation
Positive Regulation Of Cell Adhesion
Negative Regulation Of Gene Expression
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?