CD22 and CD19

Number of citations of the paper that reports this interaction (PMID 9120258)
10

Data Source:
HPRD (in vivo)

		CD22	CD19
Gene Name		CD22 molecule	CD19 molecule
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane External Side Of Plasma Membrane Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Carbohydrate Binding	Receptor Signaling Protein Activity
	Biological Process	Cell Adhesion	Cellular Defense Response Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Immune Response B Cell Receptor Signaling Pathway Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Pathways			Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs
Diseases
GWAS			Crohn's disease ( 21102463)
Protein-Protein Interactions		16 interactors: AP2M1 ATP2B4 CD19 GRB2 HP IGHM INPP5D LCP2 LYN PIK3R1 PLCG1 PTPN6 PTPRC SHC1 ST6GAL1 SYK	21 interactors: ABL1 BTK CBL CD22 CD79A CD79B CD81 CD82 CD9 CR2 ECT2 FYN GRB2 LYN MAPK1 PIK3R1 PLCG2 SOS1 SYK VAV1 VAV2
Entrez ID		933	930
HPRD ID		00114	00113
Ensembl ID		ENSG00000012124	ENSG00000177455
Uniprot IDs		P20273 Q0EAF5 Q32M46	P15391
PDB IDs
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune System Process Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Regulation Of Immune Response Wound Healing Leukocyte Migration Fc-epsilon Receptor Signaling Pathway Immune Response Regulation Of Immune System Process Positive Regulation Of Immune Response Defense Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Signaling Pathway Response To Wounding Innate Immune Response Platelet Activation B Cell Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Response To Stress Positive Regulation Of Cell Activation Epidermal Growth Factor Receptor Signaling Pathway Cell Migration ERBB Signaling Pathway Locomotion Cell Motility Regulation Of Lymphocyte Activation Positive Regulation Of T Cell Activation Neurotrophin TRK Receptor Signaling Pathway Regulation Of B Cell Differentiation Positive Regulation Of Homotypic Cell-cell Adhesion Cell Activation Neurotrophin Signaling Pathway Movement Of Cell Or Subcellular Component T Cell Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion Regulation Of Cell Activation Regulation Of Kinase Activity Regulation Of T Cell Activation Cell Surface Receptor Signaling Pathway Regulation Of Phosphorylation Response To Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway	Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Immune Response Cell Activation Fc Receptor Signaling Pathway Platelet Activation B Cell Receptor Signaling Pathway Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Regulation Of Immune System Process Blood Coagulation Hemostasis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Phagocytosis Regulation Of Body Fluid Levels Innate Immune Response Wound Healing Enzyme Linked Receptor Protein Signaling Pathway Response To Wounding Immune Response Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Surface Receptor Signaling Pathway Leukocyte Activation Immune System Process Defense Response Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Lymphocyte Activation Endocytosis Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Activation Cellular Response To Fibroblast Growth Factor Stimulus Peptidyl-tyrosine Autophosphorylation Response To Fibroblast Growth Factor Intracellular Signal Transduction Vesicle-mediated Transport Cellular Response To Growth Factor Stimulus Leukocyte Migration Response To Growth Factor Response To Organic Substance Regulation Of Lymphocyte Activation Chemotaxis Locomotion
Tagcloud ?		arthritis arthropathy cd1 cd15 cd3 chemoattractant enlarged focally granulocytes hybridisation immunoblot immunophenotype immunophenotypes infiltrate interdigitating intima kim4 kim8 leucocyte lining lymphocytes multinucleated perivascular preferential psoriatic synovial synovitis traffic vicinity	bmt cd11b cd11c cd45 cd5 cytometric cytopenias deferral definitive dilemma gating hairy hcl hodgkin immunophenotyping maturing mdf morphologic multidimensional myeloblast myelodysplasia pancytopenia phenotyping presumptive refined reside scatter scheme unexplained
Tagcloud (Difference) ?		arthritis arthropathy cd1 cd15 cd3 chemoattractant enlarged focally granulocytes hybridisation immunoblot immunophenotype immunophenotypes infiltrate interdigitating intima kim4 kim8 leucocyte lining lymphocytes multinucleated perivascular preferential psoriatic synovial synovitis traffic vicinity	bmt cd11b cd11c cd45 cd5 cytometric cytopenias deferral definitive dilemma gating hairy hcl hodgkin immunophenotyping maturing mdf morphologic multidimensional myeloblast myelodysplasia pancytopenia phenotyping presumptive refined reside scatter scheme unexplained
Tagcloud (Intersection) ?