CD22 and LCP2

Number of citations of the paper that reports this interaction (PubMedID 15668918)
0

Data Source:
HPRD (in vitro)

		CD22	LCP2
Description		CD22 molecule	lymphocyte cytosolic protein 2
Image
GO Annotations	Cellular Component	Cytoplasm Early Endosome Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Neuronal Cell Body Membrane Recycling Endosome Extracellular Exosome	Cytoplasm Cytosol Cell-cell Junction TCR Signalosome Plasma Membrane Raft
	Molecular Function	IgM Binding Signaling Receptor Binding Protein Binding Protein Phosphatase Binding Carbohydrate Binding Sialic Acid Binding CD4 Receptor Binding	Protein Binding
	Biological Process	Negative Regulation Of Immunoglobulin Production Negative Regulation Of Immune System Process Cell Adhesion Negative Regulation Of Signal Transduction Regulation Of Endocytosis Regulation Of B Cell Proliferation B Cell Activation Regulation Of Immune Response Negative Regulation Of Calcium-mediated Signaling Negative Regulation Of B Cell Receptor Signaling Pathway	Immune System Process Immune Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Intracellular Signal Transduction Mast Cell Activation Positive Regulation Of Protein Kinase Activity T Cell Receptor Signaling Pathway
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell CD22 mediated BCR regulation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	GPVI-mediated activation cascade Generation of second messenger molecules Generation of second messenger molecules DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization
Drugs		Epratuzumab Inotuzumab ozogamicin Moxetumomab pasudotox
Diseases
GWAS		Red cell distribution width ( 32888494)	Acne (severe) ( 24927181) Body mass index and diastolic blood pressure (bivariate analysis) ( 33539483) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Liver transplant-free survival in primary sclerosing cholangitis (time to event) ( 28779025) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)
Interacting Genes		21 interacting genes: ANKRD46 AP2M1 ATP2B4 CD19 CFTR GRB2 HP IGHM INPP5D LCP2 LYN MTDH NTAQ1 PIK3R1 PLCG1 PTPN6 PTPRC SHC1 ST6GAL1 SYK TMEM140	48 interacting genes: APP BLNK CBL CD22 CLNK EGFR ELOVL6 ERBB2 ERBB3 ERBB4 FXR2 FYB1 FYN GOLGA2 GRAP2 GRB2 HCK ITK LAT LCK LMNA LNX1 LYN MAP4K1 NCK1 NCK2 PAG1 PJA1 PLCG1 PLCG2 PRAM1 PTPN6 PTPRC SH3GL2 SH3RF1 SHB SHC1 STAM2 SYK TRAT1 TXK VAV1 VAV3 WAS YBX1 YWHAE YWHAZ ZAP70
Entrez ID		933	3937
HPRD ID		00114	03362
Ensembl ID		ENSG00000012124	ENSG00000043462
Uniprot IDs		P20273 Q0EAF5	Q13094
PDB IDs		5VKJ 5VKM 5VL3 7O52	1H3H 1YWO 2EAP 2ROR 6ZCJ
Enriched GO Terms of Interacting Partners?		Antigen Receptor-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway B Cell Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Neurotrophin TRKA Receptor Binding Positive Regulation Of Immune Response Phosphotyrosine Residue Binding Regulation Of Immune Response Negative Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of B Cell Activation Negative Regulation Of Defense Response Cell Surface Receptor Signaling Pathway Negative Regulation Of Immune System Process Natural Killer Cell Mediated Cytotoxicity Regulation Of Multicellular Organismal Development Leukocyte Activation T Cell Receptor Signaling Pathway Natural Killer Cell Mediated Immunity Response To Other Organism Immune Effector Process Lymphocyte Mediated Immunity Immune System Process Regulation Of Sequestering Of Calcium Ion Cell Activation Regulation Of Immune System Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Leukocyte Mediated Immunity Lymphocyte Activation Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Monoatomic Ion Transmembrane Transport Response To External Biotic Stimulus Defense Response Regulation Of Lymphocyte Activation Intracellular Signal Transduction Leukocyte Mediated Cytotoxicity Negative Regulation Of Inflammatory Response Positive Regulation Of Lymphocyte Activation Regulation Of Release Of Sequestered Calcium Ion Into Cytosol B Cell Activation Regulation Of B Cell Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Defense Response Membrane Raft Immune Response Ephrin Receptor Binding Positive Regulation Of Cell Activation	Immune Response-activating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Signaling Pathway Phosphotyrosine Residue Binding Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Immune Response Regulation Of Immune System Process Positive Regulation Of Immune Response T Cell Receptor Signaling Pathway Positive Regulation Of Immune System Process Immune System Process Cell Surface Receptor Signaling Pathway Lymphocyte Activation Intracellular Signal Transduction Leukocyte Activation Signal Transduction Cell Activation Regulation Of MAPK Cascade Regulation Of Lymphocyte Activation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of Cell Activation Positive Regulation Of Intracellular Signal Transduction Protein Tyrosine Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of T Cell Activation Peptidyl-tyrosine Phosphorylation Fc Receptor Signaling Pathway Intracellular Signaling Cassette T Cell Activation Positive Regulation Of MAPK Cascade Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Multicellular Organismal Process Non-membrane Spanning Protein Tyrosine Kinase Activity Membrane Raft Ephrin Receptor Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Signal Transduction Positive Regulation Of Cell Activation Fc-gamma Receptor Signaling Pathway Positive Regulation Of T Cell Activation Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Lymphocyte Activation Negative Regulation Of Immune System Process Regulation Of Signaling
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