CD22 and ST6GAL1

Number of citations of the paper that reports this interaction (PMID 8702538)
5

Data Source:
HPRD (in vitro)

		CD22	ST6GAL1
Gene Name		CD22 molecule	ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane External Side Of Plasma Membrane Extracellular Vesicular Exosome	Golgi Membrane Integral Component Of Golgi Membrane Golgi Cisterna Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Carbohydrate Binding	Beta-galactoside Alpha-2,6-sialyltransferase Activity Sialyltransferase Activity
	Biological Process	Cell Adhesion	N-acetylneuraminate Metabolic Process Dolichol-linked Oligosaccharide Biosynthetic Process Protein O-linked Glycosylation Humoral Immune Response O-glycan Processing Protein N-linked Glycosylation Via Asparagine Post-translational Protein Modification Cellular Protein Metabolic Process Sialylation
Pathways			Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Transport to the Golgi and subsequent modification Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) O-linked glycosylation N-Glycan antennae elongation Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein N-glycan antennae elongation in the medial/trans-Golgi Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Termination of O-glycan biosynthesis Synthesis of substrates in N-glycan biosythesis Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Sialic acid metabolism Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) O-linked glycosylation of mucins Diseases associated with N-glycosylation of proteins
Drugs
Diseases
GWAS			Drug-induced liver injury (flucloxacillin) ( 19483685) Esophageal cancer (squamous cell) ( 22960999) IgG glycosylation ( 23382691) Type 2 diabetes ( 21874001)
Protein-Protein Interactions		16 interactors: AP2M1 ATP2B4 CD19 GRB2 HP IGHM INPP5D LCP2 LYN PIK3R1 PLCG1 PTPN6 PTPRC SHC1 ST6GAL1 SYK	1 interactors: CD22
Entrez ID		933	6480
HPRD ID		00114	00184
Ensembl ID		ENSG00000012124	ENSG00000073849
Uniprot IDs		P20273 Q0EAF5 Q32M46	B2R513 P15907
PDB IDs			4JS1 4JS2
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune System Process Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Regulation Of Immune Response Wound Healing Leukocyte Migration Fc-epsilon Receptor Signaling Pathway Immune Response Regulation Of Immune System Process Positive Regulation Of Immune Response Defense Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Signaling Pathway Response To Wounding Innate Immune Response Platelet Activation B Cell Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Response To Stress Positive Regulation Of Cell Activation Epidermal Growth Factor Receptor Signaling Pathway Cell Migration ERBB Signaling Pathway Locomotion Cell Motility Regulation Of Lymphocyte Activation Positive Regulation Of T Cell Activation Neurotrophin TRK Receptor Signaling Pathway Regulation Of B Cell Differentiation Positive Regulation Of Homotypic Cell-cell Adhesion Cell Activation Neurotrophin Signaling Pathway Movement Of Cell Or Subcellular Component T Cell Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion Regulation Of Cell Activation Regulation Of Kinase Activity Regulation Of T Cell Activation Cell Surface Receptor Signaling Pathway Regulation Of Phosphorylation Response To Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway
Tagcloud ?		arthritis arthropathy cd1 cd15 cd3 chemoattractant enlarged focally granulocytes hybridisation immunoblot immunophenotype immunophenotypes infiltrate interdigitating intima kim4 kim8 leucocyte lining lymphocytes multinucleated perivascular preferential psoriatic synovial synovitis traffic vicinity	aberrantly accumulating atlas bladder catalyzes characterizes demethylation galactose invasive invasiveness irs j82 merthylation msp nu papillary portal posttranslational pt2 pta rt112 rt4 sialic suppressive tcga unmethylated urothelium urotsa verified
Tagcloud (Difference) ?		arthritis arthropathy cd1 cd15 cd3 chemoattractant enlarged focally granulocytes hybridisation immunoblot immunophenotype immunophenotypes infiltrate interdigitating intima kim4 kim8 leucocyte lining lymphocytes multinucleated perivascular preferential psoriatic synovial synovitis traffic vicinity	aberrantly accumulating atlas bladder catalyzes characterizes demethylation galactose invasive invasiveness irs j82 merthylation msp nu papillary portal posttranslational pt2 pta rt112 rt4 sialic suppressive tcga unmethylated urothelium urotsa verified
Tagcloud (Intersection) ?