CD22 and ST6GAL1

Number of citations: 0 (PubMedID 8702538)
Data Source: HPRD (in vitro)

		CD22	ST6GAL1
Name		CD22 molecule	ST6 beta-galactoside alpha-2,6-sialyltransferase 1
Structure
GO Annotations	Cellular Component	Cytoplasm Early Endosome Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Neuronal Cell Body Membrane Recycling Endosome Extracellular Exosome	Golgi Membrane Extracellular Region Golgi Apparatus Membrane Golgi Cisterna Membrane
	Molecular Function	IgM Binding Signaling Receptor Binding Protein Binding Protein Phosphatase Binding Carbohydrate Binding Sialic Acid Binding CD4 Receptor Binding	Beta-galactoside Alpha-2,6-sialyltransferase Activity Protein Binding Sialyltransferase Activity Transferase Activity Glycosyltransferase Activity Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Immunoglobulin Production Negative Regulation Of Immune System Process Cell Adhesion Negative Regulation Of Signal Transduction Regulation Of Endocytosis Regulation Of B Cell Proliferation B Cell Activation Regulation Of Immune Response Negative Regulation Of Calcium-mediated Signaling Negative Regulation Of B Cell Receptor Signaling Pathway	N-acetylneuraminate Metabolic Process Protein Glycosylation Protein O-linked Glycosylation Via N-acetyl-galactosamine Protein N-linked Glycosylation Via Asparagine Viral Protein Processing Sialylation
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell CD22 mediated BCR regulation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Sialic acid metabolism Maturation of protein 3a Maturation of spike protein Maturation of protein 3a N-Glycan antennae elongation Termination of O-glycan biosynthesis
Drugs		Epratuzumab Inotuzumab ozogamicin Moxetumomab pasudotox	None
GWAS		Red cell distribution width ( 32888494 )	Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309 ) Albumin-globulin ratio ( 29403010 ) Drug-induced liver injury (flucloxacillin) ( 19483685 ) Eosinophil percentage of white cells ( 32888494 ) Esophageal cancer (squamous cell) ( 22960999 ) Heel bone mineral density x serum urate levels interaction ( 34046847 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) IgA nephropathy ( 26028593 ) IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis) ( 28878392 ) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392 ) IgG disialylation phenotypes (multivariate analysis) ( 28878392 ) IgG fucosylation phenotypes (multivariate analysis) ( 28878392 ) IgG galactosylation phenotypes (multivariate analysis) ( 28878392 ) IgG glycosylation ( 23382691 ) IgG monogalactosylation phenotypes (multivariate analysis) ( 28878392 ) IgG monosialylation phenotypes (multivariate analysis) ( 28878392 ) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392 32128391 ) IgG sialylation phenotypes (multivariate analysis) ( 28878392 ) Immature fraction of reticulocytes ( 32888494 ) N-glycan levels ( 31163085 ) Non-albumin protein levels ( 29403010 ) Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) ( 21130132 ) Thyroglobulin plasma levels ( 30929638 ) Type 2 diabetes ( 30718926 30297969 32499647 30054458 21874001 )
Interacting Genes		21 interacting genes: ANKRD46 AP2M1 ATP2B4 CD19 CFTR GRB2 HP IGHM INPP5D LCP2 LYN MTDH NTAQ1 PIK3R1 PLCG1 PTPN6 PTPRC SHC1 ST6GAL1 SYK TMEM140	1 interacting genes: CD22
Entrez ID		933	6480
HPRD ID		00114	00184
Ensembl ID		ENSG00000012124	ENSG00000073849
Uniprot IDs		P20273 Q0EAF5	P15907
PDB IDs		5VKJ 5VKM 5VL3 7O52	4JS1 4JS2 6QVS 6QVT
GO Terms Enriched among Interactors		Antigen Receptor-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway B Cell Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Neurotrophin TRKA Receptor Binding Positive Regulation Of Immune Response Phosphotyrosine Residue Binding Regulation Of Immune Response Negative Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of B Cell Activation Negative Regulation Of Defense Response Cell Surface Receptor Signaling Pathway Negative Regulation Of Immune System Process Natural Killer Cell Mediated Cytotoxicity Regulation Of Multicellular Organismal Development Leukocyte Activation T Cell Receptor Signaling Pathway Natural Killer Cell Mediated Immunity Response To Other Organism Immune Effector Process Lymphocyte Mediated Immunity Immune System Process Regulation Of Sequestering Of Calcium Ion Cell Activation Regulation Of Immune System Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Leukocyte Mediated Immunity Lymphocyte Activation Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Monoatomic Ion Transmembrane Transport Response To External Biotic Stimulus Defense Response Regulation Of Lymphocyte Activation Intracellular Signal Transduction Leukocyte Mediated Cytotoxicity Negative Regulation Of Inflammatory Response Positive Regulation Of Lymphocyte Activation Regulation Of Release Of Sequestered Calcium Ion Into Cytosol B Cell Activation Regulation Of B Cell Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Defense Response Membrane Raft Immune Response Ephrin Receptor Binding Positive Regulation Of Cell Activation	Peptidyl-lysine N6-acetylation L-cysteine-S-conjugate N-acetyltransferase Activity IgM Binding CD4 Receptor Binding Negative Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of Immunoglobulin Production Internal Protein Amino Acid Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor N-acetyltransferase Activity Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of Calcium-mediated Signaling Neuronal Cell Body Membrane Sialic Acid Binding Protein-lysine-acetyltransferase Activity Amyloid Fibril Formation Protein Acetylation Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Glutathione Metabolic Process Regulation Of B Cell Proliferation Regulation Of Immunoglobulin Production Endoplasmic Reticulum-Golgi Intermediate Compartment Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Protein Phosphatase Binding Regulation Of Calcium-mediated Signaling