PTPRC and PPFIA1

Number of citations of the paper that reports this interaction (PMID 9624153)
49

Data Source:
HPRD (in vitro)

		PTPRC	PPFIA1
Gene Name		protein tyrosine phosphatase, receptor type, C	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Membrane Membrane Raft Extracellular Vesicular Exosome	Cytoplasm Cytosol Focal Adhesion Presynaptic Active Zone
	Molecular Function	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Protein Kinase Binding	Signal Transducer Activity Protein Binding
	Biological Process	Negative Regulation Of T Cell Mediated Cytotoxicity Negative Regulation Of Cytokine-mediated Signaling Pathway Hematopoietic Progenitor Cell Differentiation Immunoglobulin Biosynthetic Process Negative Regulation Of Protein Kinase Activity Protein Dephosphorylation Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Cell Surface Receptor Signaling Pathway Axon Guidance Dephosphorylation T Cell Differentiation Positive Regulation Of B Cell Proliferation Peptidyl-tyrosine Dephosphorylation B Cell Proliferation Positive Regulation Of T Cell Proliferation Cell Cycle Phase Transition Positive Regulation Of Protein Kinase Activity Bone Marrow Development Stem Cell Development T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol Defense Response To Virus Regulation Of Cell Cycle Positive Regulation Of Hematopoietic Stem Cell Migration Positive Regulation Of Stem Cell Proliferation	Cell-matrix Adhesion Signal Transduction Synaptic Transmission Neurotransmitter Secretion Glutamate Secretion Negative Regulation Of Stress Fiber Assembly Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane
Pathways		TCR signaling Axon guidance Semaphorin interactions Other semaphorin interactions Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System	Dopamine Neurotransmitter Release Cycle Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Serotonin Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 20139978)
Protein-Protein Interactions		43 interactors: ANP32A CD1D CD2 CD22 CD247 CD28 CD4 CD8A CSNK2A1 CSNK2A2 CXCR4 DPP4 EZR FCGR3A FYN GANAB GRB2 IFNAR1 INSR IRS1 ITGAL JAK1 JAK2 JAK3 LCK LCP2 LGALS1 LSM1 LYN MBL2 PAEP PPFIA1 PPFIBP2 PRKCSH PTPN6 PTPRCAP RASA1 RNF11 SEMA4D SKAP1 TYK2 UHRF2 ZAP70	25 interactors: AGTPBP1 CAST CCNH CEP70 DTNB ERC1 ERC2 FAM161A GIT1 MBIP NCOA2 NDN PPFIA2 PPFIA3 PPFIBP1 PPFIBP2 PPP2R5D PTPRC PTPRD PTPRF PTPRG PTPRS TNNT1 TXLNA YWHAG
Entrez ID		5788	8500
HPRD ID		01050	11451
Ensembl ID		ENSG00000081237	ENSG00000131626
Uniprot IDs		M9MML4 P08575	B3KVS8 Q13136
PDB IDs		1YGR 1YGU
Enriched GO Terms of Interacting Partners?		Regulation Of Immune System Process Regulation Of Immune Response Positive Regulation Of Cell Activation Immune Response Immune System Process Defense Response Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Innate Immune Response Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell-cell Adhesion Regulation Of Cell Adhesion Peptidyl-tyrosine Autophosphorylation Cell Activation Positive Regulation Of Cell Adhesion Regulation Of Cell Activation Leukocyte Activation Regulation Of Lymphocyte Activation T Cell Costimulation Leukocyte Cell-cell Adhesion Positive Regulation Of Immune System Process Homotypic Cell-cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Leukocyte Aggregation Locomotion Lymphocyte Activation Single Organismal Cell-cell Adhesion Cell Surface Receptor Signaling Pathway T Cell Aggregation T Cell Activation Lymphocyte Aggregation Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction Response To Stress Immune Response-regulating Signaling Pathway Signal Transduction Movement Of Cell Or Subcellular Component Positive Regulation Of Immune Response Cell Adhesion Signaling Response To Stimulus Regulation Of Signal Transduction Cell Communication T Cell Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Positive Regulation Of Intracellular Signal Transduction	Peptidyl-tyrosine Dephosphorylation Protein Dephosphorylation Dephosphorylation Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Signaling Cell Communication Cell Cycle Phase Transition Nervous System Development G2/M Transition Of Mitotic Cell Cycle Glutamate Secretion Cellular Protein Modification Process Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Transcription Initiation From RNA Polymerase I Promoter Generation Of Neurons Transcription From RNA Polymerase I Promoter Neurogenesis Cell Adhesion Signal Transduction Negative Regulation Of Protein Kinase Activity Inactivation Of MAPK Activity Involved In Osmosensory Signaling Pathway Negative Regulation Of Kinase Activity Acid Secretion Mitotic Cell Cycle Phase Transition Cellular Response To Stimulus Immunoglobulin Biosynthetic Process Positive Regulation Of Hematopoietic Stem Cell Migration DNA-templated Transcription, Termination Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transferase Activity Phosphate-containing Compound Metabolic Process Dicarboxylic Acid Transport DNA-templated Transcription, Elongation Cellular Protein Metabolic Process Negative Regulation Of Protein Phosphorylation Neuron Differentiation C-terminal Protein Deglutamylation Regulation Of Catalytic Activity Regulation Of Protein Kinase Activity Response To Stimulus Neurotransmitter Secretion Cell Surface Receptor Signaling Pathway Developmental Process Histone Acetylation Negative Regulation Of Catalytic Activity Cerebellum Development Regulation Of Kinase Activity Negative Regulation Of Phosphorylation
Tagcloud ?		abl adaptor bcr cd45 chemistry cief cml combines crkl describes detect example focusing isoelectric limit linking lysate nanocapillary nanogram nl pg protocol ptyr207 quantities reproducible screen throughput tkis uv	11q13 aberrations acgh aiming amplicon apart band breakpoints candidates ccnd1 chosen chr comprised copies cttn distinguish fadd gain homogeneously laryngeal microarray oncogene oncogenes oraov1 q13 rearrangements reinvestigated sevenfold ways
Tagcloud (Difference) ?		abl adaptor bcr cd45 chemistry cief cml combines crkl describes detect example focusing isoelectric limit linking lysate nanocapillary nanogram nl pg protocol ptyr207 quantities reproducible screen throughput tkis uv	11q13 aberrations acgh aiming amplicon apart band breakpoints candidates ccnd1 chosen chr comprised copies cttn distinguish fadd gain homogeneously laryngeal microarray oncogene oncogenes oraov1 q13 rearrangements reinvestigated sevenfold ways
Tagcloud (Intersection) ?