CD22 and IGHM

Number of citations of the paper that reports this interaction (PubMedID 8475064)
43

Data Source:
HPRD (in vivo)

		CD22	IGHM
Description		CD22 molecule	immunoglobulin heavy constant mu
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Early Endosome Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Neuronal Cell Body Membrane Recycling Endosome Extracellular Exosome	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Membrane Immunoglobulin Complex Extracellular Exosome IgM Immunoglobulin Complex IgM B Cell Receptor Complex Pentameric IgM Immunoglobulin Complex Hexameric IgM Immunoglobulin Complex Blood Microparticle
	Molecular Function	IgM Binding Signaling Receptor Binding Protein Binding Protein Phosphatase Binding Carbohydrate Binding Sialic Acid Binding CD4 Receptor Binding	Single-stranded DNA Binding Antigen Binding Protein Binding Phosphatidylcholine Binding Immunoglobulin Receptor Binding Peptidoglycan Binding
	Biological Process	Negative Regulation Of Immunoglobulin Production Negative Regulation Of Immune System Process Cell Adhesion Negative Regulation Of Signal Transduction Regulation Of Endocytosis Regulation Of B Cell Proliferation B Cell Activation Regulation Of Immune Response Negative Regulation Of Calcium-mediated Signaling Negative Regulation Of B Cell Receptor Signaling Pathway	Adaptive Immune Response Pre-B Cell Allelic Exclusion Immune System Process Defense Response Immune Response Antibacterial Humoral Response Innate Immune Response Defense Response To Gram-negative Bacterium B Cell Receptor Signaling Pathway
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell CD22 mediated BCR regulation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs		Epratuzumab Inotuzumab ozogamicin Moxetumomab pasudotox
Diseases
GWAS		Red cell distribution width ( 32888494)	Systemic sclerosis ( 33069728)
Interacting Genes		21 interacting genes: ANKRD46 AP2M1 ATP2B4 CD19 CFTR GRB2 HP IGHM INPP5D LCP2 LYN MTDH NTAQ1 PIK3R1 PLCG1 PTPN6 PTPRC SHC1 ST6GAL1 SYK TMEM140	19 interacting genes: APP CD22 CD79A CEP72 GADD45A GSK3B HPR HSPA5 JCHAIN MAP3K20 MAPKAPK3 PTK2 SH3GL2 SMN1 TK1 UBQLN4 UFD1 VPREB1 VPREB3
Entrez ID		933	3507
HPRD ID		00114	00912
Ensembl ID		ENSG00000012124	ENSG00000211899
Uniprot IDs		P20273 Q0EAF5
PDB IDs		5VKJ 5VKM 5VL3 7O52
Enriched GO Terms of Interacting Partners?		Antigen Receptor-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway B Cell Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Neurotrophin TRKA Receptor Binding Positive Regulation Of Immune Response Phosphotyrosine Residue Binding Regulation Of Immune Response Negative Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of B Cell Activation Negative Regulation Of Defense Response Cell Surface Receptor Signaling Pathway Negative Regulation Of Immune System Process Natural Killer Cell Mediated Cytotoxicity Regulation Of Multicellular Organismal Development Leukocyte Activation T Cell Receptor Signaling Pathway Natural Killer Cell Mediated Immunity Response To Other Organism Immune Effector Process Lymphocyte Mediated Immunity Immune System Process Regulation Of Sequestering Of Calcium Ion Cell Activation Regulation Of Immune System Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Leukocyte Mediated Immunity Lymphocyte Activation Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Monoatomic Ion Transmembrane Transport Response To External Biotic Stimulus Defense Response Regulation Of Lymphocyte Activation Intracellular Signal Transduction Leukocyte Mediated Cytotoxicity Negative Regulation Of Inflammatory Response Positive Regulation Of Lymphocyte Activation Regulation Of Release Of Sequestered Calcium Ion Into Cytosol B Cell Activation Regulation Of B Cell Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Defense Response Membrane Raft Immune Response Ephrin Receptor Binding Positive Regulation Of Cell Activation	ER Overload Response Regulation Of Protein Localization To Centrosome Translational Initiation K48-linked Polyubiquitin Modification-dependent Protein Binding Regulation Of Intracellular Signal Transduction Negative Regulation Of Intracellular Signal Transduction Regulation Of Calcium-mediated Signaling Regulation Of Cellular Response To Stress Negative Regulation Of Calcium-mediated Signaling Immunoglobulin Complex Protein Autophosphorylation Molecular Function Activator Activity Amyloid-beta Complex Growth Cone Lamellipodium Neuron Projection Organization Negative Regulation Of Gene Expression Regulation Of Immune Response Regulation Of Response To Calcium Ion Amylin Binding Regulation Of Proteolysis Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Cell Communication Immune System Process Cellular Response To Nerve Growth Factor Stimulus Cellular Response To Stress Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein ER-nucleus Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Microtubule Anchoring At Centrosome Kinase Activity Integrated Stress Response Signaling Regulation Of Protein Folding In Endoplasmic Reticulum Dimeric IgA Immunoglobulin Complex Vascular Endothelial Growth Factor Receptor Signaling Pathway Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Mitotic DNA Damage Checkpoint Response To Nerve Growth Factor Negative Regulation Of Protein Localization To Nucleus Response To Mechanical Stimulus Positive Regulation Of Proteolysis Acetylcholine Receptor Activator Activity Regulation Of Cellular Component Organization PTB Domain Binding Presynapse Positive Regulation Of Apoptotic Process Collateral Sprouting In Absence Of Injury
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