PTPRC and SEMA4D

Number of citations of the paper that reports this interaction (PubMedID 11254687)
0

Data Source:
HPRD (in vivo, in vitro)

		PTPRC	SEMA4D
Description		protein tyrosine phosphatase receptor type C	semaphorin 4D
Image
GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Cell Surface Membrane Secretory Granule Membrane Bleb Membrane Raft Synapse Extracellular Exosome Cell Periphery Side Of Membrane Membrane Microdomain	Semaphorin Receptor Complex Extracellular Space Nucleoplasm Centrosome Plasma Membrane Membrane Ciliary Basal Body Postsynaptic Membrane GABA-ergic Synapse
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Signaling Receptor Binding Protein Binding Heparin Binding Hydrolase Activity Protein Kinase Binding Protein Tyrosine Kinase Inhibitor Activity Ankyrin Binding Spectrin Binding Heparan Sulfate Proteoglycan Binding	Transmembrane Signaling Receptor Activity Signaling Receptor Binding Protein Binding Semaphorin Receptor Binding Signaling Receptor Activity Neuropilin Binding Identical Protein Binding Chemorepellent Activity Receptor Ligand Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Natural Killer Cell Differentiation Negative Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Cytotoxicity Negative Regulation Of Cytokine-mediated Signaling Pathway Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Immunoglobulin Production Positive Regulation Of T Cell Mediated Immunity Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Negative Regulation Of Protein Kinase Activity Protein Dephosphorylation Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Leukocyte Cell-cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway Response To Gamma Radiation Regulation Of Gene Expression Dephosphorylation B Cell Differentiation T Cell Differentiation Positive Regulation Of B Cell Proliferation Regulation Of Interleukin-8 Production Negative Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion T Cell Proliferation B Cell Proliferation Positive Regulation Of T Cell Proliferation T Cell Activation Gamma-delta T Cell Differentiation Positive Regulation Of MAPK Cascade Cell Cycle Phase Transition Plasma Membrane Raft Distribution Positive Thymic T Cell Selection Negative Thymic T Cell Selection Positive Regulation Of T Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Protein Kinase Activity Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Alpha-beta T Cell Proliferation Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Isotype Switching To IgG Isotypes Bone Marrow Development Stem Cell Development Regulation Of Phagocytosis Positive Regulation Of Phagocytosis Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol Defense Response To Virus Regulation Of Cell Cycle Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Interleukin-4-mediated Signaling Pathway Negative Regulation Of Microglial Cell Activation Response To Aldosterone DN2 Thymocyte Differentiation Positive Regulation Of Hematopoietic Stem Cell Migration Positive Regulation Of Stem Cell Proliferation Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Neural Crest Cell Migration Positive Regulation Of Protein Phosphorylation Immune Response Cell Adhesion Negative Regulation Of Cell Adhesion Nervous System Development Axonogenesis Axon Guidance Regulation Of Cell Shape Cell Differentiation Positive Regulation Of Cell Migration Regulation Of Cell Projection Organization Positive Regulation Of Rho Protein Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Ossification Involved In Bone Maturation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Collateral Sprouting Regulation Of Dendrite Morphogenesis Positive Regulation Of Axonogenesis Negative Chemotaxis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Synapse Assembly Bone Trabecula Morphogenesis Regulation Of Biological Quality Leukocyte Aggregation Semaphorin-plexin Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Inhibitory Synapse Assembly
Pathways		Phosphorylation of CD3 and TCR zeta chains Other semaphorin interactions Neutrophil degranulation	Sema4D mediated inhibition of cell attachment and migration Sema4D induced cell migration and growth-cone collapse Other semaphorin interactions
Drugs
Diseases		T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS		Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Asthma ( 31959851 34103634 32296059 31619474 30929738) Asthma (adult onset) ( 30929738) Celiac disease and Rheumatoid arthritis ( 26546613) Crohn's disease ( 28067908 26192919) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Inflammatory bowel disease ( 26192919) LDL cholesterol levels ( 32203549) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 20139978 29403010 28017375) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 29403010 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Monocyte percentage of white cells ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 29403010 32888494) Refractive error ( 32231278) Rheumatoid arthritis (ACPA-positive) ( 24532676) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 33272962) Type 1 diabetes ( 34012112) Ulcerative colitis ( 24837172) Vitiligo ( 27723757) White blood cell count ( 32888494)	Blood protein levels ( 30072576) Body mass index ( 28296344) Brain morphology (MOSTest) ( 32665545) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		45 interacting genes: ANP32A CD1D CD2 CD22 CD247 CD28 CD4 CD8A CSNK2A1 CSNK2A2 CXCR4 DPP4 EZR FCGR3A FYN GANAB GRB2 IFNAR1 INSR IRS1 ITGAL JAK1 JAK2 JAK3 LCK LCP2 LGALS1 LSM1 LYN MAPK1 MBL2 PAEP PPFIA1 PPFIBP2 PRKCSH PTPN6 PTPRCAP RASA1 RNF11 SEMA4D SKAP1 SRC TYK2 UHRF2 ZAP70	6 interacting genes: CD72 CRK DSCAM LINC00839 PLXNB1 PTPRC
Entrez ID		5788	10507
HPRD ID		01050	03520
Ensembl ID		ENSG00000081237	ENSG00000187764
Uniprot IDs		M9MML4 P08575	E9PFD9 Q92854
PDB IDs		1YGR 1YGU 5FMV 5FN6 5FN7 8VSE	1OLZ 3OL2
Enriched GO Terms of Interacting Partners?		Leukocyte Activation Cell Surface Receptor Signaling Pathway Lymphocyte Activation Cell Activation Regulation Of Immune Response Positive Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Lymphocyte Activation T Cell Costimulation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Regulation Of Immune System Process Positive Regulation Of Lymphocyte Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Immune Response Immune System Process Regulation Of Cell-cell Adhesion Antigen Receptor-mediated Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Adhesion Positive Regulation Of T Cell Activation Regulation Of Cell Activation Regulation Of Immune System Process Non-membrane Spanning Protein Tyrosine Kinase Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Cell Adhesion Immune Response-activating Signaling Pathway Immune Response Activation Of Immune Response T Cell Activation Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway T Cell Receptor Signaling Pathway Phosphotyrosine Residue Binding Peptidyl-tyrosine Phosphorylation Protein Tyrosine Kinase Activity Fc-gamma Receptor Signaling Pathway Positive Regulation Of Multicellular Organismal Process Protein Kinase Activity Protein Phosphorylation Regulation Of Leukocyte Proliferation Phosphorylation Immune Effector Process Signaling Receptor Binding Lymphocyte Differentiation Regulation Of Mononuclear Cell Proliferation Fc Receptor Signaling Pathway Mononuclear Cell Differentiation	Regulation Of Cell Adhesion Protein Tyrosine Kinase Binding Signaling Receptor Binding Regulation Of Locomotion Regulation Of Neuron Projection Development Positive Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Cell Development Positive Regulation Of Axonogenesis Negative Regulation Of Cell Adhesion Plasma Membrane Raft Distribution Negative Regulation Of Immune System Process Helper T Cell Diapedesis Regulation Of Catalytic Activity Protein Phosphorylated Amino Acid Binding Regulation Of Leukocyte Mediated Cytotoxicity Response To Cholecystokinin Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Synapse Assembly Negative Regulation Of Interleukin-4-mediated Signaling Pathway Positive Regulation Of Hematopoietic Stem Cell Migration Positive Regulation Of Locomotion Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of GTPase Activity Regulation Of Cell Shape Cerebellar Neuron Development Regulation Of Axonogenesis Membrane Microdomain Regulation Of Cell Projection Organization Positive Regulation Of Cell Growth DN2 Thymocyte Differentiation Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Regulation Of Immune Response Transmembrane Signaling Receptor Activity Negative Regulation Of B Cell Receptor Signaling Pathway Cell Adhesion Regulation Of Cell Motility Negative Regulation Of Immune Response Regulation Of Cell Migration Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of Anatomical Structure Morphogenesis Diapedesis Positive Regulation Of Growth Cell Surface Receptor Signaling Pathway Negative Regulation Of Defense Response Cellular Response To Insulin-like Growth Factor Stimulus Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Response To Endothelin Cellular Response To Endothelin Regulation Of Lymphocyte Mediated Immunity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?