CD22 and ATP2B4

Number of citations of the paper that reports this interaction (PMID 15133509)
14

Data Source:
HPRD (in vivo, in vitro)

		CD22	ATP2B4
Gene Name		CD22 molecule	ATPase, Ca++ transporting, plasma membrane 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane External Side Of Plasma Membrane Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Caveola Membrane Z Disc T-tubule Protein Complex
	Molecular Function	Protein Binding Carbohydrate Binding	Calcium-transporting ATPase Activity Protein Binding Calmodulin Binding ATP Binding Sodium Channel Regulator Activity Protein Phosphatase 2B Binding Nitric-oxide Synthase Inhibitor Activity Metal Ion Binding Nitric-oxide Synthase Binding Scaffold Protein Binding
	Biological Process	Cell Adhesion	Regulation Of Transcription From RNA Polymerase II Promoter Cellular Calcium Ion Homeostasis Blood Coagulation Metabolic Process Negative Regulation Of Nitric Oxide Mediated Signal Transduction Positive Regulation Of Peptidyl-serine Phosphorylation Ion Transmembrane Transport Negative Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Nitric-oxide Synthase Activity Response To Hydrostatic Pressure Calcium Ion Homeostasis Transmembrane Transport Calcium Ion Transmembrane Transport Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Epinephrine Stimulus Calcium Ion Import Across Plasma Membrane Negative Regulation Of The Force Of Heart Contraction Negative Regulation Of Arginine Catabolic Process Negative Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of Peptidyl-cysteine S-nitrosylation Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Citrulline Biosynthetic Process Positive Regulation Of CAMP-dependent Protein Kinase Activity
Pathways			Ion transport by P-type ATPases Ion channel transport Platelet homeostasis Reduction of cytosolic Ca++ levels Platelet calcium homeostasis
Drugs
Diseases
GWAS			Breast size ( 22747683) Malaria ( 22895189) Mean corpuscular hemoglobin concentration ( 23263863)
Protein-Protein Interactions		16 interactors: AP2M1 ATP2B4 CD19 GRB2 HP IGHM INPP5D LCP2 LYN PIK3R1 PLCG1 PTPN6 PTPRC SHC1 ST6GAL1 SYK	11 interactors: CASK CD22 DLG1 DLG2 DLG3 DLG4 ERBB2IP NOS1 PPP3CA RASSF1 SRC
Entrez ID		933	493
HPRD ID		00114	00159
Ensembl ID		ENSG00000012124	ENSG00000058668
Uniprot IDs		P20273 Q0EAF5 Q32M46	P23634
PDB IDs			1CFF 2KNE
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune System Process Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Regulation Of Immune Response Wound Healing Leukocyte Migration Fc-epsilon Receptor Signaling Pathway Immune Response Regulation Of Immune System Process Positive Regulation Of Immune Response Defense Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Signaling Pathway Response To Wounding Innate Immune Response Platelet Activation B Cell Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Response To Stress Positive Regulation Of Cell Activation Epidermal Growth Factor Receptor Signaling Pathway Cell Migration ERBB Signaling Pathway Locomotion Cell Motility Regulation Of Lymphocyte Activation Positive Regulation Of T Cell Activation Neurotrophin TRK Receptor Signaling Pathway Regulation Of B Cell Differentiation Positive Regulation Of Homotypic Cell-cell Adhesion Cell Activation Neurotrophin Signaling Pathway Movement Of Cell Or Subcellular Component T Cell Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion Regulation Of Cell Activation Regulation Of Kinase Activity Regulation Of T Cell Activation Cell Surface Receptor Signaling Pathway Regulation Of Phosphorylation Response To Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway	Receptor Localization To Synapse Nucleotide Phosphorylation Protein Localization To Synapse Establishment Or Maintenance Of Apical/basal Cell Polarity Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Cell Polarity Nucleotide Metabolic Process Synaptic Transmission Cell Adhesion Nucleobase-containing Small Molecule Metabolic Process Positive Regulation Of Transport Cellular Protein Localization Protein Localization To Membrane Axon Guidance Membrane Organization Negative Regulation Of Hydrolase Activity Regulation Of Ion Transmembrane Transport Cell-cell Signaling Organophosphate Metabolic Process Cortical Actin Cytoskeleton Organization Axonogenesis Phosphorylation Phosphate-containing Compound Metabolic Process Cortical Cytoskeleton Organization Signaling Protein Localization Positive Regulation Of Ion Transport Axon Development Cell Communication Negative Regulation Of Cell Adhesion Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Regulation Of Sodium Ion Transmembrane Transport Regulation Of Ion Transport Negative Regulation Of Cell-matrix Adhesion Locomotion Neuron Projection Morphogenesis Cell Cycle Regulation Of Membrane Potential Cell Morphogenesis Involved In Differentiation Positive Regulation Of Metabolic Process Negative Regulation Of Cell-substrate Adhesion Small Molecule Metabolic Process Anatomical Structure Development Regulation Of Catalytic Activity Myotube Differentiation Regulation Of Phosphorus Metabolic Process Cellular Localization Regulation Of Synaptic Transmission
Tagcloud ?		arthritis arthropathy cd1 cd15 cd3 chemoattractant enlarged focally granulocytes hybridisation immunoblot immunophenotype immunophenotypes infiltrate interdigitating intima kim4 kim8 leucocyte lining lymphocytes multinucleated perivascular preferential psoriatic synovial synovitis traffic vicinity
Tagcloud (Difference) ?		arthritis arthropathy cd1 cd15 cd3 chemoattractant enlarged focally granulocytes hybridisation immunoblot immunophenotype immunophenotypes infiltrate interdigitating intima kim4 kim8 leucocyte lining lymphocytes multinucleated perivascular preferential psoriatic synovial synovitis traffic vicinity
Tagcloud (Intersection) ?