PTPRC and PTPRCAP

Number of citations of the paper that reports this interaction (PMID 8537410)
2

Data Source:
HPRD (in vitro)

		PTPRC	PTPRCAP
Gene Name		protein tyrosine phosphatase, receptor type, C	protein tyrosine phosphatase, receptor type, C-associated protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Membrane Membrane Raft Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Protein Kinase Binding
	Biological Process	Negative Regulation Of T Cell Mediated Cytotoxicity Negative Regulation Of Cytokine-mediated Signaling Pathway Hematopoietic Progenitor Cell Differentiation Immunoglobulin Biosynthetic Process Negative Regulation Of Protein Kinase Activity Protein Dephosphorylation Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Cell Surface Receptor Signaling Pathway Axon Guidance Dephosphorylation T Cell Differentiation Positive Regulation Of B Cell Proliferation Peptidyl-tyrosine Dephosphorylation B Cell Proliferation Positive Regulation Of T Cell Proliferation Cell Cycle Phase Transition Positive Regulation Of Protein Kinase Activity Bone Marrow Development Stem Cell Development T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol Defense Response To Virus Regulation Of Cell Cycle Positive Regulation Of Hematopoietic Stem Cell Migration Positive Regulation Of Stem Cell Proliferation	Defense Response
Pathways		TCR signaling Axon guidance Semaphorin interactions Other semaphorin interactions Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 20139978)
Protein-Protein Interactions		43 interactors: ANP32A CD1D CD2 CD22 CD247 CD28 CD4 CD8A CSNK2A1 CSNK2A2 CXCR4 DPP4 EZR FCGR3A FYN GANAB GRB2 IFNAR1 INSR IRS1 ITGAL JAK1 JAK2 JAK3 LCK LCP2 LGALS1 LSM1 LYN MBL2 PAEP PPFIA1 PPFIBP2 PRKCSH PTPN6 PTPRCAP RASA1 RNF11 SEMA4D SKAP1 TYK2 UHRF2 ZAP70	2 interactors: EEF1A1 PTPRC
Entrez ID		5788	5790
HPRD ID		01050	09032
Ensembl ID		ENSG00000081237
Uniprot IDs		M9MML4 P08575	Q14761
PDB IDs		1YGR 1YGU
Enriched GO Terms of Interacting Partners?		Regulation Of Immune System Process Regulation Of Immune Response Positive Regulation Of Cell Activation Immune Response Immune System Process Defense Response Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Innate Immune Response Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell-cell Adhesion Regulation Of Cell Adhesion Peptidyl-tyrosine Autophosphorylation Cell Activation Positive Regulation Of Cell Adhesion Regulation Of Cell Activation Leukocyte Activation Regulation Of Lymphocyte Activation T Cell Costimulation Leukocyte Cell-cell Adhesion Positive Regulation Of Immune System Process Homotypic Cell-cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Leukocyte Aggregation Locomotion Lymphocyte Activation Single Organismal Cell-cell Adhesion Cell Surface Receptor Signaling Pathway T Cell Aggregation T Cell Activation Lymphocyte Aggregation Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction Response To Stress Immune Response-regulating Signaling Pathway Signal Transduction Movement Of Cell Or Subcellular Component Positive Regulation Of Immune Response Cell Adhesion Signaling Response To Stimulus Regulation Of Signal Transduction Cell Communication T Cell Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Positive Regulation Of Intracellular Signal Transduction	Immunoglobulin Biosynthetic Process Positive Regulation Of Hematopoietic Stem Cell Migration Negative Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Isotype Switching To IgG Isotypes Bone Marrow Development Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Gamma-delta T Cell Differentiation Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Positive Thymic T Cell Selection Positive Regulation Of Gamma-delta T Cell Activation Negative Regulation Of Protein Autophosphorylation Regulation Of Gamma-delta T Cell Differentiation Negative Regulation Of T Cell Mediated Immunity Negative Thymic T Cell Selection Positive Regulation Of Alpha-beta T Cell Proliferation Negative T Cell Selection Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of Humoral Immune Response Heterotypic Cell-cell Adhesion Thymic T Cell Selection Positive Regulation Of Isotype Switching Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Positive T Cell Selection Response To Epidermal Growth Factor Regulation Of Protein Autophosphorylation Regulation Of B Cell Differentiation Regulation Of Isotype Switching Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Immunoglobulin Mediated Immune Response Negative Regulation Of Adaptive Immune Response Substrate-dependent Cell Migration Negative Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Sequestering Of Calcium Ion Positive Regulation Of Immunoglobulin Production B Cell Receptor Signaling Pathway Positive Regulation Of B Cell Proliferation Negative Regulation Of Response To Cytokine Stimulus B Cell Proliferation T Cell Selection Calcium Ion Transport Into Cytosol Cytosolic Calcium Ion Transport Negative Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Humoral Immune Response Response To Gamma Radiation Regulation Of B Cell Proliferation Immunoglobulin Production Regulation Of DNA Recombination T Cell Differentiation In Thymus
Tagcloud ?		abl adaptor bcr cd45 chemistry cief cml combines crkl describes detect example focusing isoelectric limit linking lysate nanocapillary nanogram nl pg protocol ptyr207 quantities reproducible screen throughput tkis uv	agtrl2 biased bioinformatic chrna5 ctsg cyp2d6 dld ercc1 gabra1 gabrp heritable hip1 hnrph3 igkv1 il24 impossible kcnj15 kcnk6 klk1 msmb myoc nonfunctional notch4 npy2r orm2 pedf st16 sult1a1 unfortunately
Tagcloud (Difference) ?		abl adaptor bcr cd45 chemistry cief cml combines crkl describes detect example focusing isoelectric limit linking lysate nanocapillary nanogram nl pg protocol ptyr207 quantities reproducible screen throughput tkis uv	agtrl2 biased bioinformatic chrna5 ctsg cyp2d6 dld ercc1 gabra1 gabrp heritable hip1 hnrph3 igkv1 il24 impossible kcnj15 kcnk6 klk1 msmb myoc nonfunctional notch4 npy2r orm2 pedf st16 sult1a1 unfortunately
Tagcloud (Intersection) ?