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PTPRC and PAICS
PTPRC
PAICS
Description
protein tyrosine phosphatase receptor type C
phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
Image
GO Annotations
Cellular Component
Plasma Membrane
Focal Adhesion
External Side Of Plasma Membrane
Cytoplasmic Side Of Plasma Membrane
Cell Surface
Membrane
Secretory Granule Membrane
Bleb
Membrane Raft
Synapse
Extracellular Exosome
Cell Periphery
Side Of Membrane
Membrane Microdomain
Cytoplasm
Cytosol
Membrane
Extracellular Exosome
Molecular Function
Phosphoprotein Phosphatase Activity
Protein Tyrosine Phosphatase Activity
Transmembrane Receptor Protein Tyrosine Phosphatase Activity
Signaling Receptor Binding
Protein Binding
Heparin Binding
Hydrolase Activity
Protein Kinase Binding
Protein Tyrosine Kinase Inhibitor Activity
Ankyrin Binding
Spectrin Binding
Heparan Sulfate Proteoglycan Binding
Nucleotide Binding
Catalytic Activity
Phosphoribosylaminoimidazole Carboxylase Activity
Phosphoribosylaminoimidazolesuccinocarboxamide Synthase Activity
Protein Binding
ATP Binding
Lyase Activity
Carboxy-lyase Activity
Ligase Activity
Identical Protein Binding
Cadherin Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
Natural Killer Cell Differentiation
Negative Regulation Of T Cell Mediated Cytotoxicity
Positive Regulation Of T Cell Mediated Cytotoxicity
Negative Regulation Of Cytokine-mediated Signaling Pathway
Hematopoietic Progenitor Cell Differentiation
Positive Regulation Of Immunoglobulin Production
Positive Regulation Of T Cell Mediated Immunity
Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin
Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin
Negative Regulation Of Protein Kinase Activity
Protein Dephosphorylation
Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration
Leukocyte Cell-cell Adhesion
Signal Transduction
Cell Surface Receptor Signaling Pathway
Response To Gamma Radiation
Regulation Of Gene Expression
Dephosphorylation
B Cell Differentiation
T Cell Differentiation
Positive Regulation Of B Cell Proliferation
Regulation Of Interleukin-8 Production
Negative Regulation Of Interleukin-2 Production
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Tumor Necrosis Factor Production
Heterotypic Cell-cell Adhesion
T Cell Proliferation
B Cell Proliferation
Positive Regulation Of T Cell Proliferation
T Cell Activation
Gamma-delta T Cell Differentiation
Positive Regulation Of MAPK Cascade
Cell Cycle Phase Transition
Plasma Membrane Raft Distribution
Positive Thymic T Cell Selection
Negative Thymic T Cell Selection
Positive Regulation Of T Cell Differentiation
Positive Regulation Of Gamma-delta T Cell Differentiation
Positive Regulation Of Protein Kinase Activity
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Alpha-beta T Cell Proliferation
Positive Regulation Of Alpha-beta T Cell Proliferation
Positive Regulation Of Isotype Switching To IgG Isotypes
Bone Marrow Development
Stem Cell Development
Regulation Of Phagocytosis
Positive Regulation Of Phagocytosis
Positive Regulation Of Calcium-mediated Signaling
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Regulation Of T Cell Receptor Signaling Pathway
Positive Regulation Of Antigen Receptor-mediated Signaling Pathway
Release Of Sequestered Calcium Ion Into Cytosol
Defense Response To Virus
Regulation Of Cell Cycle
Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Interleukin-4-mediated Signaling Pathway
Negative Regulation Of Microglial Cell Activation
Response To Aldosterone
DN2 Thymocyte Differentiation
Positive Regulation Of Hematopoietic Stem Cell Migration
Positive Regulation Of Stem Cell Proliferation
Regulation Of Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Purine Nucleotide Biosynthetic Process
GMP Biosynthetic Process
'de Novo' IMP Biosynthetic Process
Purine Nucleobase Biosynthetic Process
'de Novo' AMP Biosynthetic Process
'de Novo' XMP Biosynthetic Process
Pathways
Phosphorylation of CD3 and TCR zeta chains
Other semaphorin interactions
Neutrophil degranulation
Purine ribonucleoside monophosphate biosynthesis
Drugs
Aspartic acid
Diseases
T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS
Apolipoprotein B levels (
32203549
)
Aspartate aminotransferase levels (
33547301
)
Asthma (
31959851
34103634
32296059
31619474
30929738
)
Asthma (adult onset) (
30929738
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Crohn's disease (
28067908
26192919
)
Eosinophil count (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Inflammatory bowel disease (
26192919
)
LDL cholesterol levels (
32203549
)
Lymphocyte count (
27863252
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Mean corpuscular hemoglobin (
20139978
29403010
28017375
)
Mean corpuscular hemoglobin concentration (
29403010
)
Mean corpuscular volume (
29403010
32888494
)
Mean platelet volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Medication use (adrenergics, inhalants) (
31015401
)
Monocyte percentage of white cells (
32888494
)
Plateletcrit (
32888494
)
Red blood cell count (
29403010
32888494
)
Refractive error (
32231278
)
Rheumatoid arthritis (ACPA-positive) (
24532676
)
Sum eosinophil basophil counts (
27863252
)
Systemic lupus erythematosus (
27399966
33272962
)
Type 1 diabetes (
34012112
)
Ulcerative colitis (
24837172
)
Vitiligo (
27723757
)
White blood cell count (
32888494
)
Interacting Genes
45 interacting genes:
ANP32A
CD1D
CD2
CD22
CD247
CD28
CD4
CD8A
CSNK2A1
CSNK2A2
CXCR4
DPP4
EZR
FCGR3A
FYN
GANAB
GRB2
IFNAR1
INSR
IRS1
ITGAL
JAK1
JAK2
JAK3
LCK
LCP2
LGALS1
LSM1
LYN
MAPK1
MBL2
PAEP
PPFIA1
PPFIBP2
PRKCSH
PTPN6
PTPRCAP
RASA1
RNF11
SEMA4D
SKAP1
SRC
TYK2
UHRF2
ZAP70
26 interacting genes:
ASB11
CDC37
CEBPA
CEP76
CHD3
FXR1
FXR2
L3MBTL2
LCOR
LINC00632
LNX1
MOB4
NIF3L1
NUDT18
PIAS2
PILRA
PRKAG1
RAD54L2
RNF4
SMARCD1
SNCA
TERF1
UBE2I
UBE3A
USP30
ZMYM2
Entrez ID
5788
10606
HPRD ID
01050
01401
Ensembl ID
ENSG00000081237
ENSG00000128050
Uniprot IDs
M9MML4
P08575
P22234
PDB IDs
1YGR
1YGU
5FMV
5FN6
5FN7
8VSE
2H31
6YB8
6YB9
7ALE
Enriched GO Terms of Interacting Partners
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Leukocyte Activation
Cell Surface Receptor Signaling Pathway
Lymphocyte Activation
Cell Activation
Regulation Of Immune Response
Positive Regulation Of Cell-cell Adhesion
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Lymphocyte Activation
T Cell Costimulation
Regulation Of Leukocyte Cell-cell Adhesion
Regulation Of T Cell Activation
Positive Regulation Of Cell Activation
Positive Regulation Of Immune System Process
Positive Regulation Of Lymphocyte Activation
Positive Regulation Of Leukocyte Cell-cell Adhesion
Positive Regulation Of Immune Response
Immune System Process
Regulation Of Cell-cell Adhesion
Antigen Receptor-mediated Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Cell Adhesion
Positive Regulation Of T Cell Activation
Regulation Of Cell Activation
Regulation Of Immune System Process
Non-membrane Spanning Protein Tyrosine Kinase Activity
Immune Response-regulating Signaling Pathway
Positive Regulation Of Cell Adhesion
Immune Response-activating Signaling Pathway
Immune Response
Activation Of Immune Response
T Cell Activation
Signal Transduction
Enzyme-linked Receptor Protein Signaling Pathway
T Cell Receptor Signaling Pathway
Phosphotyrosine Residue Binding
Peptidyl-tyrosine Phosphorylation
Protein Tyrosine Kinase Activity
Fc-gamma Receptor Signaling Pathway
Positive Regulation Of Multicellular Organismal Process
Protein Kinase Activity
Protein Phosphorylation
Regulation Of Leukocyte Proliferation
Phosphorylation
Immune Effector Process
Signaling Receptor Binding
Lymphocyte Differentiation
Regulation Of Mononuclear Cell Proliferation
Fc Receptor Signaling Pathway
Mononuclear Cell Differentiation
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Primary Metabolic Process
PML Body
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Metabolic Process
Regulation Of Long-term Neuronal Synaptic Plasticity
Regulation Of Translation At Presynapse, Modulating Synaptic Transmission
Negative Regulation Of Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Metabolic Process
Postsynapse
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Long-term Neuronal Synaptic Plasticity
Regulation Of Macrophage Activation
Regulation Of Neuronal Synaptic Plasticity
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Gene Expression
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Catabolic Process
Post-translational Protein Modification
Protein Kinase Regulator Activity
Regulation Of Synaptic Plasticity
Positive Regulation Of Biosynthetic Process
Translation Regulator Activity
Positive Regulation Of Macromolecule Metabolic Process
ATP-dependent Chromatin Remodeler Activity
SUMO Transferase Activity
Negative Regulation Of Transcription By RNA Polymerase II
Protein Modification Process
Protein Modification By Small Protein Conjugation
Dentate Gyrus Development
Modulation Of Chemical Synaptic Transmission
Postsynaptic Cytosol
Positive Regulation Of Protein Metabolic Process
Response To Lipid
RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding
Positive Regulation Of RNA Metabolic Process
Regulation Of Cell Cycle
Plasma Membrane Raft Distribution
Transcription Coregulator Activity
Response To Desipramine
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