PAICS and PRKAG1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PAICS	PRKAG1
Gene Name		phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase	protein kinase, AMP-activated, gamma 1 non-catalytic subunit
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Gene Ontology Annotations	Cellular Component	Cytosol Membrane Extracellular Vesicular Exosome	Nucleus Cytosol Membrane AMP-activated Protein Kinase Complex Extracellular Vesicular Exosome
	Molecular Function	Phosphoribosylaminoimidazole Carboxylase Activity Phosphoribosylaminoimidazolesuccinocarboxamide Synthase Activity Protein Binding ATP Binding Identical Protein Binding	Protein Kinase Activity AMP-activated Protein Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding CAMP-dependent Protein Kinase Regulator Activity AMP Binding Protein Kinase Binding ADP Binding
	Biological Process	Purine Nucleobase Metabolic Process 'de Novo' IMP Biosynthetic Process Purine Nucleobase Biosynthetic Process Purine Ribonucleoside Monophosphate Biosynthetic Process Small Molecule Metabolic Process Nucleobase-containing Small Molecule Metabolic Process	Regulation Of Glycolytic Process Protein Phosphorylation Fatty Acid Biosynthetic Process Organelle Organization Mitochondrion Organization Cell Cycle Arrest Signal Transduction Spermatogenesis Insulin Receptor Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Protein Kinase Activity Protein Heterooligomerization Membrane Organization
Pathways		Purine ribonucleoside monophosphate biosynthesis Purine metabolism Metabolism of nucleotides	Organelle biogenesis and maintenance Insulin receptor signalling cascade Regulation of AMPK activity via LKB1 IRS-mediated signalling Regulation of Rheb GTPase activity by AMPK mTOR signalling Translocation of GLUT4 to the plasma membrane IRS-related events mTOR signalling IGF1R signaling cascade Mitochondrial biogenesis IRS-related events triggered by IGF1R Activation of PPARGC1A (PGC-1alpha) by phosphorylation IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade PKB-mediated events PI3K Cascade Signaling by Insulin receptor
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: CEP76 CHD3 FXR2 L3MBTL2 LNX1 MOB4 NIF3L1 NUDT18 PRKAG1 SMARCD1 TERF1	15 interactors: ACACA AP1S3 C1orf94 CBS KCNN4 KEAP1 KRTAP10-3 KRTAP4-2 PAICS PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG2 TEKT1
Entrez ID		10606	5571
HPRD ID		01401	04118
Ensembl ID		ENSG00000128050	ENSG00000181929
Uniprot IDs		P22234	F8W9D1 P54619
PDB IDs		2H31	2UV4 2UV5 2UV6 2UV7
Enriched GO Terms of Interacting Partners?		Chromatin Modification Chromatin Organization GDP Catabolic Process DGDP Catabolic Process DADP Catabolic Process Chromosome Organization Protein Oligomerization Cell Cycle Process 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Organelle Organization G2/M Transition Of Mitotic Cell Cycle Telomeric Loop Formation Age-dependent Telomere Shortening Dihydrobiopterin Metabolic Process Telomere Maintenance Via Telomere Shortening Regulation Of Microtubule Cytoskeleton Organization Chromatin Assembly Or Disassembly Cell Cycle Purine Ribonucleoside Diphosphate Catabolic Process Nucleobase-containing Small Molecule Catabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Microtubule-based Process Ribonucleoside Diphosphate Catabolic Process Nucleoside Diphosphate Catabolic Process Replicative Cell Aging Regulation Of Nuclear Cell Cycle DNA Replication Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Chromatin-mediated Maintenance Of Transcription Deoxyribonucleoside Diphosphate Metabolic Process Regulation Of Telomere Maintenance Via Telomerase Regulation Of Centriole Replication Purine Ribonucleoside Catabolic Process Protein Homooligomerization Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Microtubule Polymerization Nucleosome Disassembly Regulation Of Telomerase Activity Regulation Of Cell Cycle Deoxyribose Phosphate Catabolic Process Positive Regulation Of Gene Expression, Epigenetic Regulation Of Telomere Maintenance Protein Complex Assembly RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Purine Ribonucleotide Catabolic Process Regulation Of Glycolytic Process	Carnitine Shuttle Carnitine Transmembrane Transport Carnitine Transport Fatty Acid Biosynthetic Process Quaternary Ammonium Group Transport Long-chain Fatty Acid Transport Fatty Acid Metabolic Process Ammonium Transmembrane Transport Cell Cycle Arrest Insulin Receptor Signaling Pathway Fatty Acid Transport Ammonium Transport Cellular Response To Insulin Stimulus Lipid Biosynthetic Process Monocarboxylic Acid Metabolic Process Carboxylic Acid Metabolic Process Response To Insulin Lipid Transport Cellular Response To Peptide Hormone Stimulus Organic Acid Metabolic Process Regulation Of Glycolytic Process Lipid Localization Cellular Response To Peptide Monocarboxylic Acid Transport Regulation Of Lipid Biosynthetic Process Energy Reserve Metabolic Process Regulation Of Fatty Acid Biosynthetic Process Mitochondrial Transport Membrane Organization Organic Anion Transport Sterol Biosynthetic Process Negative Regulation Of Cell Cycle Response To Peptide Hormone Small Molecule Metabolic Process Cellular Response To Organonitrogen Compound Response To Peptide Cellular Lipid Metabolic Process Cellular Response To Hormone Stimulus Inorganic Anion Transport Regulation Of Generation Of Precursor Metabolites And Energy Monovalent Inorganic Cation Transport Anion Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Fatty Acid Metabolic Process Regulation Of Lipid Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Carboxylic Acid Transport Organic Acid Transport Lipid Metabolic Process Regulation Of Energy Homeostasis
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