PAICS and SMARCD1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PAICS	SMARCD1
Gene Name		phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Membrane Extracellular Vesicular Exosome	SWI/SNF Complex NpBAF Complex NBAF Complex
	Molecular Function	Phosphoribosylaminoimidazole Carboxylase Activity Phosphoribosylaminoimidazolesuccinocarboxamide Synthase Activity Protein Binding ATP Binding Identical Protein Binding	Transcription Coactivator Activity Protein Binding Protein Complex Scaffold
	Biological Process	Purine Nucleobase Metabolic Process 'de Novo' IMP Biosynthetic Process Purine Nucleobase Biosynthetic Process Purine Ribonucleoside Monophosphate Biosynthetic Process Small Molecule Metabolic Process Nucleobase-containing Small Molecule Metabolic Process	Nucleosome Disassembly Chromatin Remodeling Regulation Of Transcription From RNA Polymerase II Promoter Nervous System Development Chromatin-mediated Maintenance Of Transcription
Pathways		Purine ribonucleoside monophosphate biosynthesis Purine metabolism Metabolism of nucleotides	Chromatin modifying enzymes Chromatin organization RMTs methylate histone arginines
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: CEP76 CHD3 FXR2 L3MBTL2 LNX1 MOB4 NIF3L1 NUDT18 PRKAG1 SMARCD1 TERF1	44 interactors: ANP32B APOA5 AR C4BPA CALCOCO2 CCDC85B CDC5L CDX2 CORO1A DPF3 EGFL7 ESR1 FEZ1 FOS GATA1 GCC1 HNRNPC HSPB1 IGKC JUN KDM1A KLF1 KRT15 KRT18 LDOC1 MED4 NME1 NONO NR1H4 NR3C1 NUCB2 PAICS PCBD1 PGR PRDX1 PRMT6 RIF1 RPS29 SUV420H1 TNIP2 TP53 USHBP1 VPS37B YWHAG
Entrez ID		10606	6602
HPRD ID		01401	03438
Ensembl ID		ENSG00000128050	ENSG00000066117
Uniprot IDs		P22234	Q96GM5
PDB IDs		2H31
Enriched GO Terms of Interacting Partners?		Chromatin Modification Chromatin Organization GDP Catabolic Process DGDP Catabolic Process DADP Catabolic Process Chromosome Organization Protein Oligomerization Cell Cycle Process 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Organelle Organization G2/M Transition Of Mitotic Cell Cycle Telomeric Loop Formation Age-dependent Telomere Shortening Dihydrobiopterin Metabolic Process Telomere Maintenance Via Telomere Shortening Regulation Of Microtubule Cytoskeleton Organization Chromatin Assembly Or Disassembly Cell Cycle Purine Ribonucleoside Diphosphate Catabolic Process Nucleobase-containing Small Molecule Catabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Microtubule-based Process Ribonucleoside Diphosphate Catabolic Process Nucleoside Diphosphate Catabolic Process Replicative Cell Aging Regulation Of Nuclear Cell Cycle DNA Replication Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Chromatin-mediated Maintenance Of Transcription Deoxyribonucleoside Diphosphate Metabolic Process Regulation Of Telomere Maintenance Via Telomerase Regulation Of Centriole Replication Purine Ribonucleoside Catabolic Process Protein Homooligomerization Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Microtubule Polymerization Nucleosome Disassembly Regulation Of Telomerase Activity Regulation Of Cell Cycle Deoxyribose Phosphate Catabolic Process Positive Regulation Of Gene Expression, Epigenetic Regulation Of Telomere Maintenance Protein Complex Assembly RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Purine Ribonucleotide Catabolic Process Regulation Of Glycolytic Process	RNA Biosynthetic Process Gene Expression Transcription, DNA-templated RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Macromolecule Biosynthetic Process Biosynthetic Process Regulation Of Apoptotic Process Positive Regulation Of Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Cell Death Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Chromatin Organization Regulation Of Gene Expression Cellular Response To Organic Substance Response To Organic Substance Developmental Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of RNA Metabolic Process Anatomical Structure Development Transcription From RNA Polymerase II Promoter System Development Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Transcription Initiation From RNA Polymerase II Promoter Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Cell Death Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Metabolic Process Multicellular Organismal Development DNA-templated Transcription, Initiation Hormone-mediated Signaling Pathway Regulation Of Cell Proliferation Cellular Response To Hormone Stimulus Regulation Of Cellular Process Chromatin Modification
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