PAICS and L3MBTL2

Number of citations of the paper that reports this interaction (PubMedID 26871637)
43

Data Source:
BioGRID (two hybrid)

		PAICS	L3MBTL2
Description		phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase	L3MBTL histone methyl-lysine binding protein 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Extracellular Exosome	Nucleus Nucleoplasm
	Molecular Function	Nucleotide Binding Catalytic Activity Phosphoribosylaminoimidazole Carboxylase Activity Phosphoribosylaminoimidazolesuccinocarboxamide Synthase Activity Protein Binding ATP Binding Lyase Activity Carboxy-lyase Activity Ligase Activity Identical Protein Binding Cadherin Binding	Chromatin Binding Protein Binding Zinc Ion Binding Histone Binding Metal Ion Binding Histone H4K20me2 Reader Activity Histone H4K20me1 Reader Activity Promoter-specific Chromatin Binding
	Biological Process	Purine Nucleotide Biosynthetic Process GMP Biosynthetic Process 'de Novo' IMP Biosynthetic Process Purine Nucleobase Biosynthetic Process 'de Novo' AMP Biosynthetic Process 'de Novo' XMP Biosynthetic Process	Chromatin Organization Regulation Of DNA-templated Transcription Ectoderm Development Negative Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Stem Cell Differentiation Stem Cell Proliferation
Pathways		Purine ribonucleoside monophosphate biosynthesis	SUMOylation of chromatin organization proteins Transcriptional Regulation by E2F6
Drugs		Aspartic acid
Diseases
GWAS			Adventurousness ( 30643258) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Anxiety ( 33859377) Autism spectrum disorder or schizophrenia ( 28540026) Crohn's disease ( 26192919) Depression ( 29700475) General risk tolerance (MTAG) ( 30643258) Inflammatory bowel disease ( 26192919) Lamb consumption ( 32066663) Major depressive disorder ( 27479909) Neuroticism ( 27918536 29255261) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		26 interacting genes: ASB11 CDC37 CEBPA CEP76 CHD3 FXR1 FXR2 L3MBTL2 LCOR LINC00632 LNX1 MOB4 NIF3L1 NUDT18 PIAS2 PILRA PRKAG1 RAD54L2 RNF4 SMARCD1 SNCA TERF1 UBE2I UBE3A USP30 ZMYM2	49 interacting genes: AMOTL2 BEND7 BIVM CARD9 CCDC106 CCDC33 CEP76 DRC4 EFHC2 EIF4ENIF1 FAM217B GKAP1 GOLGA2 GPRASP3 H3C1 H4C1 HSF2BP LNX2 MEAF6 MEOX1 MPP3 NRF1 PAICS PHF10 PIAS1 PICK1 POU6F2 PRKAR1B RBAK REL SSUH2 STAC3 STAM2 TAX1BP1 TBC1D9B TEKT1 THAP1 THAP11 TLE5 TNNI1 TRIM42 TRIM50 TSPYL1 ZBTB26 ZBTB48 ZFP64 ZFY ZNF467 ZNF829
Entrez ID		10606	83746
HPRD ID		01401	13954
Ensembl ID		ENSG00000128050	ENSG00000100395
Uniprot IDs		P22234	A0A0S2Z5X6 Q969R5
PDB IDs		2H31 6YB8 6YB9 7ALE	2W0T 3CEY 3F70
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process PML Body Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Postsynapse Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Macrophage Activation Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Catabolic Process Post-translational Protein Modification Protein Kinase Regulator Activity Regulation Of Synaptic Plasticity Positive Regulation Of Biosynthetic Process Translation Regulator Activity Positive Regulation Of Macromolecule Metabolic Process ATP-dependent Chromatin Remodeler Activity SUMO Transferase Activity Negative Regulation Of Transcription By RNA Polymerase II Protein Modification Process Protein Modification By Small Protein Conjugation Dentate Gyrus Development Modulation Of Chemical Synaptic Transmission Postsynaptic Cytosol Positive Regulation Of Protein Metabolic Process Response To Lipid RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Plasma Membrane Raft Distribution Transcription Coregulator Activity Response To Desipramine	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
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