PAICS and ASB11

Number of citations of the paper that reports this interaction (PubMedID 37848033)
0

Data Source:
BioGRID (enzymatic study)

		PAICS	ASB11
Description		phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase	ankyrin repeat and SOCS box containing 11
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GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Extracellular Exosome	Endoplasmic Reticulum Cytosol Cul5-RING Ubiquitin Ligase Complex
	Molecular Function	Nucleotide Binding Catalytic Activity Phosphoribosylaminoimidazole Carboxylase Activity Phosphoribosylaminoimidazolesuccinocarboxamide Synthase Activity Protein Binding ATP Binding Lyase Activity Carboxy-lyase Activity Ligase Activity Identical Protein Binding Cadherin Binding	Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Purine Nucleotide Biosynthetic Process GMP Biosynthetic Process 'de Novo' IMP Biosynthetic Process Purine Nucleobase Biosynthetic Process 'de Novo' AMP Biosynthetic Process 'de Novo' XMP Biosynthetic Process	Protein Ubiquitination Endoplasmic Reticulum Unfolded Protein Response Intracellular Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Protein K11-linked Ubiquitination
Pathways		Purine ribonucleoside monophosphate biosynthesis	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Aspartic acid
Diseases
GWAS			vascular endothelial growth factor D levels ( 25147954)
Interacting Genes		26 interacting genes: ASB11 CDC37 CEBPA CEP76 CHD3 FXR1 FXR2 L3MBTL2 LCOR LINC00632 LNX1 MOB4 NIF3L1 NUDT18 PIAS2 PILRA PRKAG1 RAD54L2 RNF4 SMARCD1 SNCA TERF1 UBE2I UBE3A USP30 ZMYM2	7 interacting genes: BIK CUL5 ELOB ELOC PAICS RNF7 UBC
Entrez ID		10606	140456
HPRD ID		01401	06450
Ensembl ID		ENSG00000128050	ENSG00000165192
Uniprot IDs		P22234	Q8WXH4
PDB IDs		2H31 6YB8 6YB9 7ALE	4UUC
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process PML Body Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Postsynapse Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Macrophage Activation Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Catabolic Process Post-translational Protein Modification Protein Kinase Regulator Activity Regulation Of Synaptic Plasticity Positive Regulation Of Biosynthetic Process Translation Regulator Activity Positive Regulation Of Macromolecule Metabolic Process ATP-dependent Chromatin Remodeler Activity SUMO Transferase Activity Negative Regulation Of Transcription By RNA Polymerase II Protein Modification Process Protein Modification By Small Protein Conjugation Dentate Gyrus Development Modulation Of Chemical Synaptic Transmission Postsynaptic Cytosol Positive Regulation Of Protein Metabolic Process Response To Lipid RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Plasma Membrane Raft Distribution Transcription Coregulator Activity Response To Desipramine	Cul5-RING Ubiquitin Ligase Complex Target-directed MiRNA Degradation Elongin Complex Negative Regulation Of Focal Adhesion Disassembly Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Erythropoietin-mediated Signaling Pathway Negative Regulation Of Growth Hormone Receptor Signaling Pathway MiRNA Catabolic Process Regulation Of Growth Hormone Receptor Signaling Pathway Reelin-mediated Signaling Pathway Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Macromolecule Catabolic Process Negative Regulation Of MiRNA-mediated Gene Silencing Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cul2-RING Ubiquitin Ligase Complex Layer Formation In Cerebral Cortex Negative Regulation Of Focal Adhesion Assembly Modification-dependent Protein Catabolic Process MiRNA Metabolic Process Growth Hormone Receptor Signaling Pathway Regulation Of MiRNA-mediated Gene Silencing Regulation Of Post-transcriptional Gene Silencing CGAS/STING Signaling Pathway Positive Regulation Of Focal Adhesion Assembly Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Cell-matrix Adhesion Protein K11-linked Ubiquitination Protein Modification Process Transcription Initiation At RNA Polymerase II Promoter Regulation Of Neuron Migration Transcription Corepressor Binding Ubiquitin Protein Ligase Binding SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell-matrix Adhesion Negative Regulation Of Cell-substrate Adhesion Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Regulation Of Focal Adhesion Assembly DNA-templated Transcription Initiation Regulation Of Cell-substrate Junction Organization Phosphoribosylaminoimidazolesuccinocarboxamide Synthase Activity Phosphoribosylaminoimidazole Carboxylase Activity Epithelial To Mesenchymal Transition Proteolysis Mesenchymal Cell Differentiation Cytoplasmic Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Cell Junction Assembly Symbiont-mediated Suppression Of Host Innate Immune Response
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