PAICS and NIF3L1

Number of citations of the paper that reports this interaction (PMID 19060904)
157

Data Source:
BioGRID (two hybrid)

		PAICS	NIF3L1
Gene Name		phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase	NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Membrane Extracellular Vesicular Exosome	Cytoplasm Mitochondrion
	Molecular Function	Phosphoribosylaminoimidazole Carboxylase Activity Phosphoribosylaminoimidazolesuccinocarboxamide Synthase Activity Protein Binding ATP Binding Identical Protein Binding	GTP Cyclohydrolase I Activity Protein Binding GTP Binding Transcription Factor Binding Metal Ion Binding
	Biological Process	Purine Nucleobase Metabolic Process 'de Novo' IMP Biosynthetic Process Purine Nucleobase Biosynthetic Process Purine Ribonucleoside Monophosphate Biosynthetic Process Small Molecule Metabolic Process Nucleobase-containing Small Molecule Metabolic Process	7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Positive Regulation Of Transcription, DNA-templated
Pathways		Purine ribonucleoside monophosphate biosynthesis Purine metabolism Metabolism of nucleotides
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: CEP76 CHD3 FXR2 L3MBTL2 LNX1 MOB4 NIF3L1 NUDT18 PRKAG1 SMARCD1 TERF1	64 interactors: AP5B1 APIP ARPIN BEND7 CCDC102B CCDC85B CDKN2B CDKN2C COIL COPS2 CUTC DCDC2 DCTD DCTPP1 DHPS DMC1 DMRTB1 DUSP23 DYNLT3 EIF5A2 ENOX1 EPHB6 FAM49B FXR2 GNMT GRB2 KCTD17 KRT15 KXD1 LAMTOR3 LMO2 MAGEA11 MAPRE2 MLXIPL NATD1 NME1 NOL3 NUDT14 NUDT21 ORC5 PAICS PCBD1 PRTFDC1 RABAC1 RAD54B RPIA S100A1 SAT1 SNF8 STAT3 STK16 SULT1A2 SULT1A3 SYT17 THOC7 TIFA TRAF2 TRIM21 TRIP13 TSC22D4 VIM YES1 YWHAQ ZBED1
Entrez ID		10606	60491
HPRD ID		01401	10424
Ensembl ID		ENSG00000128050	ENSG00000196290
Uniprot IDs		P22234	Q9GZT8
PDB IDs		2H31
Enriched GO Terms of Interacting Partners?		Chromatin Modification Chromatin Organization GDP Catabolic Process DGDP Catabolic Process DADP Catabolic Process Chromosome Organization Protein Oligomerization Cell Cycle Process 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Organelle Organization G2/M Transition Of Mitotic Cell Cycle Telomeric Loop Formation Age-dependent Telomere Shortening Dihydrobiopterin Metabolic Process Telomere Maintenance Via Telomere Shortening Regulation Of Microtubule Cytoskeleton Organization Chromatin Assembly Or Disassembly Cell Cycle Purine Ribonucleoside Diphosphate Catabolic Process Nucleobase-containing Small Molecule Catabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Microtubule-based Process Ribonucleoside Diphosphate Catabolic Process Nucleoside Diphosphate Catabolic Process Replicative Cell Aging Regulation Of Nuclear Cell Cycle DNA Replication Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Chromatin-mediated Maintenance Of Transcription Deoxyribonucleoside Diphosphate Metabolic Process Regulation Of Telomere Maintenance Via Telomerase Regulation Of Centriole Replication Purine Ribonucleoside Catabolic Process Protein Homooligomerization Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Microtubule Polymerization Nucleosome Disassembly Regulation Of Telomerase Activity Regulation Of Cell Cycle Deoxyribose Phosphate Catabolic Process Positive Regulation Of Gene Expression, Epigenetic Regulation Of Telomere Maintenance Protein Complex Assembly RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Purine Ribonucleotide Catabolic Process Regulation Of Glycolytic Process	Protein Oligomerization Nucleobase-containing Compound Metabolic Process Protein Tetramerization Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Nitrogen Compound Metabolic Process Nucleoside Metabolic Process 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Protein Complex Assembly Protein Homotetramerization Purine Nucleoside Metabolic Process Protein Homooligomerization Peptidyl-lysine Modification To Peptidyl-hypusine Polyamine Metabolic Process Polyamine Catabolic Process Ribose Phosphate Metabolic Process Reciprocal Meiotic Recombination Nucleotide Metabolic Process Amine Metabolic Process Ribonucleotide Metabolic Process Biosynthetic Process Cellular Metabolic Process Purine Nucleotide Metabolic Process S-adenosylmethionine Metabolic Process Methionine Metabolic Process Regulation Of Protein Homodimerization Activity Cellular Component Assembly Sulfation Sulfur Compound Metabolic Process Positive Regulation Of T Cell Activation Gene Expression Amine Biosynthetic Process Oocyte Maturation Positive Regulation Of Homotypic Cell-cell Adhesion Transcription, DNA-templated Regulation Of Glycolytic Process Meiosis I Organophosphate Metabolic Process Male Meiosis I Cell Cycle Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cell-cell Adhesion RNA Biosynthetic Process Response To Injury Involved In Regulation Of Muscle Adaptation Deoxyhypusine Biosynthetic Process From Spermidine Glucose Mediated Signaling Pathway Polyamine Homeostasis Response To Brefeldin A
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