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PAICS and NUDT18
Number of citations of the paper that reports this interaction (PMID
16189514
)
699
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
PAICS
NUDT18
Gene Name
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
nudix (nucleoside diphosphate linked moiety X)-type motif 18
Image
Gene Ontology Annotations
Cellular Component
Cytosol
Membrane
Extracellular Vesicular Exosome
Cytosol
Molecular Function
Phosphoribosylaminoimidazole Carboxylase Activity
Phosphoribosylaminoimidazolesuccinocarboxamide Synthase Activity
Protein Binding
ATP Binding
Identical Protein Binding
Magnesium Ion Binding
Protein Binding
8-oxo-dGDP Phosphatase Activity
8-oxo-GDP Phosphatase Activity
8-hydroxy-dADP Phosphatase Activity
Biological Process
Purine Nucleobase Metabolic Process
'de Novo' IMP Biosynthetic Process
Purine Nucleobase Biosynthetic Process
Purine Ribonucleoside Monophosphate Biosynthetic Process
Small Molecule Metabolic Process
Nucleobase-containing Small Molecule Metabolic Process
Nucleobase-containing Small Molecule Catabolic Process
Small Molecule Metabolic Process
DADP Catabolic Process
DGDP Catabolic Process
GDP Catabolic Process
Nucleobase-containing Small Molecule Metabolic Process
Pathways
Purine ribonucleoside monophosphate biosynthesis
Purine metabolism
Metabolism of nucleotides
Drugs
Diseases
GWAS
Protein-Protein Interactions
11 interactors:
CEP76
CHD3
FXR2
L3MBTL2
LNX1
MOB4
NIF3L1
NUDT18
PRKAG1
SMARCD1
TERF1
34 interactors:
APIP
COIL
CUTC
DCTD
DHPS
DUT
EVI5L
GLUL
GNMT
GSE1
HSD17B14
KCTD13
KCTD17
KHDRBS3
KRT15
KRTAP4-12
KXD1
NADK
NAT9
NT5C2
PAICS
PCBD1
PSME3
RAB3IL1
RABAC1
RAD54B
RWDD1
SDPR
TARBP2
TERF2IP
TIFA
TRAF2
TRIM37
ZBED1
Entrez ID
10606
79873
HPRD ID
01401
07992
Ensembl ID
ENSG00000128050
Uniprot IDs
P22234
Q6ZVK8
PDB IDs
2H31
3GG6
Enriched GO Terms of Interacting Partners
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Chromatin Modification
Chromatin Organization
GDP Catabolic Process
DGDP Catabolic Process
DADP Catabolic Process
Chromosome Organization
Protein Oligomerization
Cell Cycle Process
7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process
Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication
Organelle Organization
G2/M Transition Of Mitotic Cell Cycle
Telomeric Loop Formation
Age-dependent Telomere Shortening
Dihydrobiopterin Metabolic Process
Telomere Maintenance Via Telomere Shortening
Regulation Of Microtubule Cytoskeleton Organization
Chromatin Assembly Or Disassembly
Cell Cycle
Purine Ribonucleoside Diphosphate Catabolic Process
Nucleobase-containing Small Molecule Catabolic Process
Negative Regulation Of Telomere Maintenance Via Telomerase
Regulation Of Microtubule-based Process
Ribonucleoside Diphosphate Catabolic Process
Nucleoside Diphosphate Catabolic Process
Replicative Cell Aging
Regulation Of Nuclear Cell Cycle DNA Replication
Negative Regulation Of Telomerase Activity
Telomere Maintenance Via Telomerase
Negative Regulation Of Telomere Maintenance
Chromatin-mediated Maintenance Of Transcription
Deoxyribonucleoside Diphosphate Metabolic Process
Regulation Of Telomere Maintenance Via Telomerase
Regulation Of Centriole Replication
Purine Ribonucleoside Catabolic Process
Protein Homooligomerization
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Positive Regulation Of Microtubule Polymerization
Nucleosome Disassembly
Regulation Of Telomerase Activity
Regulation Of Cell Cycle
Deoxyribose Phosphate Catabolic Process
Positive Regulation Of Gene Expression, Epigenetic
Regulation Of Telomere Maintenance
Protein Complex Assembly
RNA-dependent DNA Replication
Negative Regulation Of DNA Biosynthetic Process
Purine Ribonucleotide Catabolic Process
Regulation Of Glycolytic Process
Protein Homooligomerization
Protein Oligomerization
Nucleoside Metabolic Process
Protein Tetramerization
Nucleobase-containing Small Molecule Metabolic Process
Protein Complex Assembly
Cellular Nitrogen Compound Metabolic Process
Cellular Component Assembly
Protein Homotetramerization
Nitrogen Compound Metabolic Process
Catabolic Process
Small Molecule Metabolic Process
S-adenosylmethionine Metabolic Process
Purine Nucleoside Metabolic Process
Methionine Metabolic Process
Regulation Of Protein Homodimerization Activity
IMP Metabolic Process
Alpha-amino Acid Metabolic Process
Nucleotide Biosynthetic Process
Positive Regulation Of NF-kappaB Transcription Factor Activity
Nucleotide Metabolic Process
Polyamine Metabolic Process
Cofactor Metabolic Process
Nucleobase-containing Compound Metabolic Process
Pyrimidine Nucleobase Metabolic Process
Protein Autoubiquitination
Purine Nucleobase Metabolic Process
Sulfur Amino Acid Metabolic Process
DUMP Biosynthetic Process
Deoxyhypusine Biosynthetic Process From Spermidine
DUTP Catabolic Process
Negative Regulation Of DNA Recombination At Telomere
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Pyrimidine Nucleoside Biosynthetic Process
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Cellular Amino Acid Metabolic Process
I-kappaB Kinase/NF-kappaB Signaling
Glutamine Biosynthetic Process
MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA
Spermidine Catabolic Process
L-methionine Biosynthetic Process From S-adenosylmethionine
Cellular Modified Amino Acid Metabolic Process
Pyrimidine Nucleotide Metabolic Process
Pyrimidine Nucleoside Metabolic Process
Targeting Of MRNA For Destruction Involved In RNA Interference
DUMP Metabolic Process
NADP Biosynthetic Process
DUTP Metabolic Process
Negative Regulation Of Cilium Assembly
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