PTPN9 and GHR

Number of citations of the paper that reports this interaction (PMID 12907755)
14

Data Source:
BioGRID (pull down, far western blotting)

		PTPN9	GHR
Gene Name		protein tyrosine phosphatase, non-receptor type 9	growth hormone receptor
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm	Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Integral Component Of Membrane Receptor Complex Growth Hormone Receptor Complex
	Molecular Function	Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding	Cytokine Receptor Activity Protein Binding Peptide Hormone Binding Growth Factor Binding Protein Kinase Binding Protein Homodimerization Activity Proline-rich Region Binding
	Biological Process	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation	Activation Of MAPK Activity Allantoin Metabolic Process Citrate Metabolic Process 2-oxoglutarate Metabolic Process Succinate Metabolic Process Oxaloacetate Metabolic Process Isoleucine Metabolic Process Valine Metabolic Process Creatine Metabolic Process Fatty Acid Metabolic Process Endocytosis JAK-STAT Cascade Cytokine-mediated Signaling Pathway Taurine Metabolic Process Receptor Internalization Response To Estradiol Cellular Response To Hormone Stimulus Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Activation Of JAK2 Kinase Activity Multicellular Organismal Metabolic Process Creatinine Metabolic Process Response To Cycloheximide Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Growth Hormone Receptor Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway
Pathways			Nuclear signaling by ERBB4 Cytokine Signaling in Immune system Signaling by ERBB4 Prolactin receptor signaling Growth hormone receptor signaling
Drugs			Somatropin recombinant Pegvisomant
Diseases
GWAS		Height ( 20189936)	Iron status biomarkers ( 19084217) Response to taxane treatment (docetaxel) ( 23006423) Systemic lupus erythematosus ( 18204098)
Protein-Protein Interactions		8 interactors: AGTRAP CMTM5 GHR MAL2 NSF REEP6 RTN3 STX6	33 interactors: AP2A1 BTRC CISH DUSP7 GH1 GH2 GRB10 GRB2 IRS1 JAK1 JAK2 NCOA6 PIK3R1 PLCG1 PTPN1 PTPN11 PTPN13 PTPN2 PTPN3 PTPN6 PTPN9 PTPRB PTPRH SGTA SHC1 SOCS1 SOCS2 SOCS3 STAT3 STAT5A STAT5B STUB1 TYK2
Entrez ID		5780	2690
HPRD ID		02864	02971
Ensembl ID		ENSG00000169410	ENSG00000112964
Uniprot IDs		P43378	P10912
PDB IDs		2PA5 4GE2 4GE5 4GE6	1A22 1AXI 1HWG 1HWH 1KF9 2AEW 3HHR
Enriched GO Terms of Interacting Partners?		Endomembrane System Organization Vesicle-mediated Transport Golgi Vesicle Docking Membrane Fusion Activation Of JAK2 Kinase Activity Creatinine Metabolic Process Isoleucine Metabolic Process Golgi Ribbon Formation Allantoin Metabolic Process Taurine Metabolic Process Activation Of Janus Kinase Activity Angiotensin-activated Signaling Pathway Endoplasmic Reticulum Tubular Network Organization Golgi Vesicle Transport Valine Metabolic Process Creatine Metabolic Process Response To Cycloheximide Succinate Metabolic Process 2-oxoglutarate Metabolic Process Oxaloacetate Metabolic Process Positive Regulation Of Receptor Recycling Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Plasma Membrane Fusion Insulin-like Growth Factor Receptor Signaling Pathway	Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Growth Hormone Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide JAK-STAT Cascade Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Cellular Response To Organic Substance Cellular Response To Hormone Stimulus Response To Organic Substance Response To Hormone Response To Organonitrogen Compound Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Regulation Of Innate Immune Response Negative Regulation Of Insulin Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Signal Transduction Intracellular Signal Transduction Signal Transduction Regulation Of Cellular Response To Insulin Stimulus Regulation Of Signaling Response To Cytokine Regulation Of Immune System Process Regulation Of Cytokine-mediated Signaling Pathway Signaling Protein Dephosphorylation Cell Communication Peptidyl-tyrosine Dephosphorylation Regulation Of Insulin Receptor Signaling Pathway Innate Immune Response Regulation Of Phosphorylation Defense Response Regulation Of Kinase Activity Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Cellular Protein Modification Process Immune System Process Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Signaling Neurotrophin TRK Receptor Signaling Pathway
Tagcloud ?		autophosphorylation called coimmunopricipitated couple da ecs fundamental indentified jak jak1 janus kinases lastly meg2 mutant nonreceptor phosphatases preferentially ptps searched substrate substrates trapping tyk2 tyr1175 tyrosine vegf vegfr2	becomes ceptor continuous continuously cwsv dephosphorylation eliminated h7 internalization involves jak2 labile lived maintain maximal mg132 obligatory ongoing persisted pervanadate phosphotyrosine proteasome pulse requirement robust stat5b step sustaining
Tagcloud (Difference) ?		autophosphorylation called coimmunopricipitated couple da ecs fundamental indentified jak jak1 janus kinases lastly meg2 mutant nonreceptor phosphatases preferentially ptps searched substrate substrates trapping tyk2 tyr1175 tyrosine vegf vegfr2	becomes ceptor continuous continuously cwsv dephosphorylation eliminated h7 internalization involves jak2 labile lived maintain maximal mg132 obligatory ongoing persisted pervanadate phosphotyrosine proteasome pulse requirement robust stat5b step sustaining
Tagcloud (Intersection) ?