PTPN9 and CREB3L1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PTPN9	CREB3L1
Description		protein tyrosine phosphatase non-receptor type 9	cAMP responsive element binding protein 3 like 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Neuron Projection Terminus	Chromatin Nucleus Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity	Transcription Cis-regulatory Region Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding CAMP Response Element Binding SMAD Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Dephosphorylation Signal Transduction Negative Regulation Of Neuron Projection Development Peptidyl-tyrosine Dephosphorylation Positive Regulation Of Protein Localization To Plasma Membrane	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Response To Unfolded Protein Negative Regulation Of Gene Expression Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Collagen Biosynthetic Process Response To Endoplasmic Reticulum Stress Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Extracellular Matrix Constituent Secretion Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Sprouting Angiogenesis
Pathways		Interleukin-37 signaling	CREB3 factors activate genes
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31015462) Height ( 20189936 25429064 31562340 33713608) Hip circumference adjusted for BMI ( 34021172) Type 2 diabetes ( 30297969)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Fasting blood glucose ( 22581228) HDL cholesterol levels ( 32203549) LDL cholesterol ( 30275531) Medication use (diuretics) ( 31015401) Offspring birth weight ( 31043758) Peripheral artery disease ( 31285632) Schizophrenia ( 29483656) Serum metabolite levels ( 33031748) Systolic blood pressure ( 30578418)
Interacting Genes		46 interacting genes: AGTRAP AQP6 ARL13B ARL6IP1 ATP5PF BSND CCR2 CDR1 CERS4 CMTM4 CMTM5 COQ3 CPLX4 CREB3 CREB3L1 DERL2 EBP FAM114A2 FKBP7 GET1 GHR GJB1 GORAB HSD17B11 HSD17B13 LIME1 LMNA MAL2 NSF PBX3 PEX12 PLIN3 REEP6 RTN3 SCAMP1 SLC16A13 SLC30A8 SLC7A1 SPAG4 STX6 SYP TMCO2 TMEM80 TMEM86B TMX2 YIF1A	195 interacting genes: ADAM33 ADGRE2 ADIPOQ AGPAT3 AGPAT4 AGPAT5 ALG8 ANKRD46 AOC3 APOD AQP10 AQP2 ARLN ARV1 ASGR1 BET1 BMP10 BNIP3 BRICD5 C11orf24 C5 CCL4L2 CD53 CD72 CD99L2 CFHR5 CFTR CIAO2A CLN6 CMTM3 CMTM7 CNIH2 COL8A2 COMT COX20 CREB3 CREB3L3 CREM CSGALNACT2 CTSA CTXN3 CXCL16 CYB561D2 CYBC1 CYP4F2 DDIT3 DOLK EBP EMP3 ENTPD3 ERG28 ERMP1 FA2H FAM3C FAXDC2 FETUB FXYD3 FXYD6 GAST GIMAP1 GIMAP5 GOLT1B GOSR2 GPR151 GPR25 GPR37L1 HACD2 HIF1A IL1RL1 INSIG2 ITGAM JAGN1 KCNK1 LEPROTL1 LHFPL5 LPAR3 LTC4S MAL MAL2 MALL MAN2B2 MARCHF2 MGAM MGST2 MGST3 MMD2 MS4A1 MS4A13 NAPB NAT8 NEU1 NINJ1 NINJ2 NRM NSG1 OLFM4 OR10AG1 ORMDL1 ORMDL2 PAQR6 PEDS1-UBE2V1 PEX16 PGAP2 PGRMC1 PLN PLP1 PLP2 PLPP4 PLPP6 PLPPR2 PMP22 PRKAB2 PTPN9 RFT1 RHBDD1 RHD RNASE10 RUNX1T1 RUSF1 SACM1L SCARF1 SCD SCGB1D1 SEC22A SEC22B SEC61G SEMA4G SFXN5 SLC13A2 SLC13A3 SLC16A13 SLC2A3 SLC30A8 SLC35A4 SLC35B1 SLC35B2 SLC35B4 SLC35H1 SLC39A2 SLC39A9 SLC52A1 SLC61A1 SLC7A1 SMCO4 SMIM1 SPOCK1 SQLE STX3 STX7 STX8 SYNGR1 SYNJ2BP TECR TEX264 TFRC TIMM23 TIMMDC1 TLCD1 TMBIM6 TMEM11 TMEM120B TMEM128 TMEM147 TMEM14A TMEM14B TMEM14C TMEM19 TMEM203 TMEM208 TMEM218 TMEM222 TMEM229B TMEM234 TMEM239 TMEM50B TMEM86A TMIE TNF TNFRSF10C TNMD TRAM1L1 TSPAN2 TSPO TSPO2 UBIAD1 UNC93B1 VAMP1 VAMP2 VEZT VKORC1 WFDC2 YIPF6 ZDHHC15 ZDHHC22 ZFPL1
Entrez ID		5780	90993
HPRD ID		02864	16751
Ensembl ID		ENSG00000169410	ENSG00000157613
Uniprot IDs		P43378 Q6IQ43	B2RA75 Q96BA8
PDB IDs		2PA5 4GE2 4GE5 4GE6 4ICZ 6KZQ 6L03
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Steroid Dehydrogenase Activity Endoplasmic Reticulum Tubular Network Formation Protein Binding Endoplasmic Reticulum Tubular Network Membrane Organization Syntaxin Binding Non-motile Cilium Assembly	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding SNAP Receptor Activity Lipid Metabolic Process Lipid Biosynthetic Process Golgi Membrane Sterol Biosynthetic Process Steroid Biosynthetic Process SNARE Complex Sterol Metabolic Process Membrane Lipid Metabolic Process Cholesterol Biosynthetic Process Structural Constituent Of Myelin Sheath Pyrimidine Nucleotide-sugar Transmembrane Transport Nucleotide-sugar Transmembrane Transport Plasma Membrane Endomembrane System Leukotriene-C4 Synthase Activity Transmembrane Transport Chloride Channel Inhibitor Activity Organic Anion Transport Mitochondrial Membrane Small Molecule Biosynthetic Process Cholesterol Metabolic Process Sphingolipid Metabolic Process Establishment Of Protein Localization Membrane Fusion Steroid Metabolic Process Heme Biosynthetic Process Myelination Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane Axon Ensheathment Vesicle Fusion CAMP Response Element Binding Protein Binding Bleb Assembly Membrane Organization Nuclear Envelope Tetrapyrrole Biosynthetic Process Porphyrin-containing Compound Biosynthetic Process Organelle Membrane Fusion Azurophil Granule CDP-diacylglycerol Biosynthetic Process Carbohydrate Derivative Transport Syntaxin Binding Cellular Localization CDP-diacylglycerol Metabolic Process Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Leukotriene Metabolic Process
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