MRTFA and MAP1LC3A

Number of citations of the paper that reports this interaction (PubMedID 35044719)
104

Data Source:
BioGRID (unspecified method)

		MRTFA	MAP1LC3A
Description		myocardin related transcription factor A	microtubule associated protein 1 light chain 3 alpha
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Autophagosome Membrane Cytoplasm Late Endosome Autophagosome Cytosol Cytoskeleton Microtubule Endomembrane System Membrane Organelle Membrane Cytoplasmic Vesicle Autolysosome Synapse Glutamatergic Synapse
	Molecular Function	Transcription Coactivator Activity Actin Binding Actin Monomer Binding Protein Binding Leucine Zipper Domain Binding	Protein Binding Phospholipid Binding Microtubule Binding Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding
	Biological Process	Actin Cytoskeleton Organization Wound Healing, Spreading Of Cells Positive Regulation Of Transcription By RNA Polymerase II Smooth Muscle Cell Differentiation Positive Regulation Of MiRNA Transcription	Autophagosome Assembly Autophagy Of Mitochondrion Mitophagy Autophagy Cellular Response To Nitrogen Starvation JNK Cascade Cellular Response To Starvation Response To Iron(II) Ion Response To Lead Ion Macroautophagy Response To Nutrient Levels Cellular Response To Amino Acid Starvation P38MAPK Cascade SMAD Protein Signal Transduction Cellular Response To Hydrogen Peroxide Cellular Response To Copper Ion Cellular Response To Oxygen-glucose Deprivation Autophagosome Maturation
Pathways		SUMOylation of transcription cofactors RHO GTPases Activate Formins	Macroautophagy PINK1-PRKN Mediated Mitophagy Receptor Mediated Mitophagy
Drugs		Latrunculin B
Diseases
GWAS		Appendicular lean mass ( 33097823)	Alanine aminotransferase levels ( 33547301) Bipolar disorder ( 31043756) Colorectal cancer or advanced adenoma ( 30510241) Fish- and plant-related diet ( 32066663) Hip circumference adjusted for BMI ( 34021172) Oily fish consumption ( 32066663) Pork consumption ( 32066663)
Interacting Genes		12 interacting genes: KDM3A MAP1LC3A MAP1LC3B MRTFB MVP MYOCD NCOA3 SMARCA4 SRF SUMO1 TRIM54 UBE2I	100 interacting genes: ABTB3 AKAP13 AMBRA1 ANK2 ANK3 ANKRD62 AP5B1 APOBR APP APPL1 ARHGAP6 ATF7IP2 ATG13 ATG2A ATG4B ATG7 ATXN3 BCL9 BNIP3L BRD9 CAMSAP1 CARS2 CCPG1 CDC37 CSAG1 DPPA4 DVL2 EPHA7 FUNDC1 GPSM1 HTATSF1 IRGQ IRS4 KIF15 KXD1 LINC00696 LMNB1 MAP1A MAP1S MAVS MDM2 MEFV MREG MRTFA MTX1 MYBPC1 NBR1 NCOR1 NEDD4 NEDD4L NEK9 NEURL4 OPRM1 OPTN PCNT PHB1 PIAS4 PRPF40A RABGAP1 RABGAP1L RASAL3 RDH12 RELB RESF1 RETREG3 RIC1 RTKN RTN3 SEC62 SLA2 SP1 SP3 SRPK1 STBD1 STK10 TBC1D1 TBC1D10A TBC1D10B TBC1D16 TBC1D17 TBC1D2 TBC1D25 TBC1D2B TBC1D5 TBC1D7 TBC1D9 TBC1D9B TMEM132C TNIP1 TP53INP1 TP53INP2 TRIM21 TRIM25 TRIM32 TTN TUBA4A VPS9D1 ZBTB48 ZKSCAN4 ZNF304
Entrez ID		57591	84557
HPRD ID		10445	03144
Ensembl ID		ENSG00000196588	ENSG00000101460
Uniprot IDs		A0A494BZX7 A0A499FIJ6 A4FUJ8 B0QY83 Q969V6 W0Z7M9	Q9H492
PDB IDs		2KVU 2KW9	3ECI 3WAL 3WAN 4ZDV 5CX3 5DPR 6TBE 7R9W 7R9Z 7RA0 8T2L 8T35 8T36 8T4T
Enriched GO Terms of Interacting Partners?		Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of MiRNA Transcription Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Smooth Muscle Cell Differentiation Cardiac Vascular Smooth Muscle Cell Differentiation Small Protein Activating Enzyme Binding Regulation Of Stem Cell Population Maintenance Vascular Associated Smooth Muscle Cell Differentiation Negative Regulation Of Amyloid-beta Clearance Cardiac Muscle Cell Myoblast Differentiation Nuclear Pore Cellular Response To Nitrogen Starvation Transcription Coactivator Activity Cardioblast Differentiation Phosphatidylethanolamine Binding Regulation Of Transcription By RNA Polymerase II Muscle Cell Differentiation Regulation Of Amyloid-beta Clearance Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Disassembly Nuclear Androgen Receptor Binding Presynaptic Cytosol Postsynaptic Cytosol Positive Regulation Of Smooth Muscle Contraction Regulation Of Muscle Contraction Myoblast Differentiation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Coregulator Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of DNA-templated Transcription Regulation Of Smooth Muscle Cell Differentiation Glutamatergic Synapse Organelle Membrane Cardiocyte Differentiation Positive Regulation Of Stem Cell Population Maintenance Chromatin Positive Regulation Of Muscle Contraction Autophagosome Maturation Regulation Of RNA Metabolic Process Transcription Initiation-coupled Chromatin Remodeling Regulation Of Muscle System Process Protein Sumoylation Positive Regulation Of Gene Expression, Epigenetic Serum Response Element Binding Cellular Response To Nutrient Levels SUMO Conjugating Enzyme Activity	Autophagosome GTPase Activator Activity Regulation Of Cilium Assembly Autophagy Macroautophagy Positive Regulation Of Catabolic Process Positive Regulation Of Autophagy Regulation Of Organelle Assembly Autophagosome Assembly Regulation Of Cell Projection Organization Autophagosome Organization Regulation Of Cell Projection Assembly Cytoplasmic Vesicle Regulation Of Autophagy Regulation Of Plasma Membrane Bounded Cell Projection Organization Autophagy Of Mitochondrion Organelle Organization Cytosol Vacuole Organization Mitophagy Positive Regulation Of Macroautophagy Regulation Of Macroautophagy Regulation Of Cellular Component Organization Piecemeal Microautophagy Of The Nucleus Regulation Of Organelle Organization Microautophagy Nucleophagy Positive Regulation Of Metabolic Process Substrate Localization To Autophagosome M Band Cytoskeleton Organization Phagophore Assembly Site Vesicle-mediated Transport Transcription Repressor Complex Intracellular Protein Localization Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Microtubule Associated Complex Regulation Of Protein Localization Negative Regulation Of Viral Process Catabolic Process Protein Kinase Regulator Activity Suppression Of Viral Release By Host Regulation Of Viral Process Regulation Of GTPase Activity Cytoplasm Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Catabolic Process Cytoskeletal Anchor Activity Protein-macromolecule Adaptor Activity
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