MKL1 and MYOCD

Number of citations of the paper that reports this interaction (PMID 14970199)
50

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		MKL1	MYOCD
Gene Name		megakaryoblastic leukemia (translocation) 1	myocardin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nucleus
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Actin Binding Actin Monomer Binding Protein Binding Leucine Zipper Domain Binding	Core Promoter Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Transcription Coactivator Activity Protein Binding Transcription Factor Binding Histone Acetyltransferase Binding Histone Deacetylase Binding R-SMAD Binding
	Biological Process	Transcription, DNA-templated Positive Regulation Of Transcription Via Serum Response Element Binding Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Smooth Muscle Cell Differentiation Negative Regulation Of Apoptotic Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Growth By Extracellular Stimulus Vasculogenesis Response To Hypoxia Cardiac Ventricle Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Myotube Differentiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cardiocyte Differentiation Regulation Of Histone Acetylation Hepatic Stellate Cell Activation Positive Regulation Of DNA Binding Cellular Component Maintenance Regulation Of Myoblast Differentiation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Smooth Muscle Contraction Lung Alveolus Development Digestive Tract Development Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Smooth Muscle Cell Differentiation Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Smooth Muscle Cell Differentiation Cardiac Muscle Cell Differentiation Ventricular Cardiac Muscle Cell Differentiation Uterus Development Urinary Bladder Development Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Growth Factor Stimulus Cellular Response To Hypoxia Ductus Arteriosus Closure Negative Regulation Of Beta-amyloid Clearance Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Smooth Muscle Cell Differentiation Positive Regulation Of Cardiac Vascular Smooth Muscle Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Differentiation Negative Regulation Of Skeletal Muscle Cell Differentiation
Pathways
Drugs
Diseases
GWAS		Breast cancer ( 23535729 23535733) Breast size ( 22747683) Height ( 19570815) Treatment response for severe sepsis ( 22310353)	Testosterone levels ( 22675492)
Protein-Protein Interactions		8 interactors: KDM3A MKL2 MVP MYOCD SMARCA4 SRF SUMO1 UBE2I	12 interactors: GOPC GSK3B KDM3A MAMSTR MKL1 MYOD1 SMAD2 SMAD3 SMARCA4 SRF STUB1 UBC
Entrez ID		57591	93649
HPRD ID		10445	09362
Ensembl ID		ENSG00000196588	ENSG00000141052
Uniprot IDs		Q969V6	Q6N065 Q8IZQ8
PDB IDs		2KVU 2KW9
Enriched GO Terms of Interacting Partners?		Smooth Muscle Cell Differentiation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Beta-amyloid Clearance Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Peptidyl-lysine Modification Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Heart Development Regulation Of Beta-amyloid Clearance Muscle Cell Differentiation Regulation Of DNA Binding Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Regulation Of Transcription From RNA Polymerase II Promoter Blood Vessel Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Cardiac Muscle Cell Myoblast Differentiation Positive Regulation Of Metabolic Process Cardioblast Differentiation Negative Regulation Of Cellular Metabolic Process Cardiac Chamber Development Heart Trabecula Formation Muscle Structure Development Blood Vessel Development Regulation Of Smooth Muscle Cell Differentiation Heart Development Vasculature Development Vascular Smooth Muscle Cell Differentiation Positive Regulation Of Transcription, DNA-templated Cardiac Muscle Tissue Development Protein Sumoylation Positive Regulation Of Smooth Muscle Contraction Heart Trabecula Morphogenesis Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Heart Morphogenesis Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of DNA Binding Regulation Of Binding Developmental Growth Myoblast Differentiation Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Signaling Cardiovascular System Development Stem Cell Differentiation	Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Negative Regulation Of Signaling Regulation Of Cellular Component Organization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter Regulation Of Binding Transcription, DNA-templated Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Nucleobase-containing Compound Metabolic Process Developmental Growth RNA Biosynthetic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Signal Transduction Muscle Cell Differentiation Cellular Nitrogen Compound Metabolic Process Cell Development Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Organic Substance Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Differentiation Response To Transforming Growth Factor Beta Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Stem Cell Differentiation Regulation Of RNA Biosynthetic Process RNA Metabolic Process Growth Regulation Of RNA Metabolic Process Smooth Muscle Cell Differentiation Positive Regulation Of Cell Development Regulation Of Gene Expression, Epigenetic Muscle Structure Development Primary MiRNA Processing Regulation Of Cell Differentiation
Tagcloud ?		arise arises conditional disassembly disrupts emt epdc epdcs epicardial epicardium lining manipulate mesothelium microvascular mkl2 mobilization motile motility mrtf mrtfa mrtfb mrtfs myocardin pericytes perinuclear shed stemming sub tracing	adaptation associate cardiac cardioenriched circuits close coactivators cofactors correlate directing discovered discuss entertained focus growing identifies inputs modulation mrtf networks nevertheless overlapping participate precise preclinical putative regulatory understand
Tagcloud (Difference) ?		arise arises conditional disassembly disrupts emt epdc epdcs epicardial epicardium lining manipulate mesothelium microvascular mkl2 mobilization motile motility mrtfa mrtfb mrtfs pericytes perinuclear shed stemming sub tracing	adaptation associate cardiac cardioenriched circuits close coactivators cofactors correlate directing discovered discuss entertained focus growing identifies inputs modulation networks nevertheless overlapping participate precise preclinical putative regulatory understand
Tagcloud (Intersection) ?		mrtf myocardin