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MKL1
Gene Name
megakaryoblastic leukemia (translocation) 1
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Transcription Coactivator Activity
Actin Binding
Actin Monomer Binding
Protein Binding
Leucine Zipper Domain Binding
Biological Process
Transcription, DNA-templated
Positive Regulation Of Transcription Via Serum Response Element Binding
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Smooth Muscle Cell Differentiation
Negative Regulation Of Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Breast cancer (
23535729
23535733
)
Breast size (
22747683
)
Height (
19570815
)
Treatment response for severe sepsis (
22310353
)
Protein-protein Interactions
8 interactors:
KDM3A
MKL2
MVP
MYOCD
SMARCA4
SRF
SUMO1
UBE2I
Entrez ID
57591
HPRD ID
10445
Ensembl ID
ENSG00000196588
Uniprot IDs
Q969V6
PDB IDs
2KVU
2KW9
Enriched GO Terms of Interacting Partners
?
Smooth Muscle Cell Differentiation
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Negative Regulation Of Beta-amyloid Clearance
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation
Peptidyl-lysine Modification
Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Heart Development
Regulation Of Beta-amyloid Clearance
Muscle Cell Differentiation
Regulation Of DNA Binding
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation
Regulation Of Transcription From RNA Polymerase II Promoter
Blood Vessel Morphogenesis
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Cardiac Muscle Cell Myoblast Differentiation
Positive Regulation Of Metabolic Process
Cardioblast Differentiation
Negative Regulation Of Cellular Metabolic Process
Cardiac Chamber Development
Heart Trabecula Formation
Muscle Structure Development
Blood Vessel Development
Regulation Of Smooth Muscle Cell Differentiation
Heart Development
Vasculature Development
Vascular Smooth Muscle Cell Differentiation
Positive Regulation Of Transcription, DNA-templated
Cardiac Muscle Tissue Development
Protein Sumoylation
Positive Regulation Of Smooth Muscle Contraction
Heart Trabecula Morphogenesis
Positive Regulation Of Cellular Metabolic Process
Regulation Of Transcription, DNA-templated
Heart Morphogenesis
Regulation Of Nucleic Acid-templated Transcription
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Gene Expression
Regulation Of RNA Metabolic Process
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of DNA Binding
Regulation Of Binding
Developmental Growth
Myoblast Differentiation
Regulation Of Metabolic Process
Regulation Of Gene Expression
Regulation Of Signaling
Cardiovascular System Development
Stem Cell Differentiation
Tagcloud
?
arise
arises
conditional
disassembly
disrupts
emt
epdc
epdcs
epicardial
epicardium
lining
manipulate
mesothelium
microvascular
mkl2
mobilization
motile
motility
mrtf
mrtfa
mrtfb
mrtfs
myocardin
pericytes
perinuclear
shed
stemming
sub
tracing