MKL1 and SMARCA4

Number of citations of the paper that reports this interaction (PMID 17599918)
21

Data Source:
BioGRID (pull down)

		MKL1	SMARCA4
Gene Name		megakaryoblastic leukemia (translocation) 1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nuclear Chromatin Heterochromatin Extracellular Space Nucleus Nucleoplasm Nuclear Euchromatin Perichromatin Fibrils Nucleolus Membrane SWI/SNF Complex Protein Complex NpBAF Complex NBAF Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Actin Binding Actin Monomer Binding Protein Binding Leucine Zipper Domain Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Transcription Coactivator Activity P53 Binding Transcription Coactivator Activity Transcription Corepressor Activity Helicase Activity Protein Binding ATP Binding DNA-dependent ATPase Activity Tat Protein Binding Nucleosomal DNA Binding Protein N-terminus Binding Androgen Receptor Binding DNA Polymerase Binding Lysine-acetylated Histone Binding
	Biological Process	Transcription, DNA-templated Positive Regulation Of Transcription Via Serum Response Element Binding Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Smooth Muscle Cell Differentiation Negative Regulation Of Apoptotic Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Morphogenesis Vasculogenesis Blastocyst Growth Blastocyst Hatching Liver Development Neural Retina Development Chromatin Organization Nucleosome Disassembly Chromatin Remodeling Methylation-dependent Chromatin Silencing Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Glial Cell Fate Determination DNA Methylation On Cytosine Within A CG Sequence Stem Cell Maintenance Positive Regulation Of Wnt Signaling Pathway Extracellular Matrix Organization Keratinocyte Differentiation Negative Regulation Of Cell Growth Forebrain Development Hindbrain Development Embryonic Hindlimb Morphogenesis Aortic Smooth Muscle Cell Differentiation ATP-dependent Chromatin Remodeling Positive Regulation Of DNA Binding Positive Regulation By Host Of Viral Transcription Histone H3 Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Organ Morphogenesis Epidermis Morphogenesis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Definitive Erythrocyte Differentiation Heart Trabecula Formation Negative Regulation Of Androgen Receptor Signaling Pathway Lens Fiber Cell Development Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			Chromatin modifying enzymes Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation formation of the beta-catenin:TCF transactivating complex XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer RMTs methylate histone arginines
Drugs
Diseases
GWAS		Breast cancer ( 23535729 23535733) Breast size ( 22747683) Height ( 19570815) Treatment response for severe sepsis ( 22310353)	Coronary heart disease ( 21347282)
Protein-Protein Interactions		8 interactors: KDM3A MKL2 MVP MYOCD SMARCA4 SRF SUMO1 UBE2I	73 interactors: ACTB ACTL6A AHR AR ARID1A ARID1B ARID2 BRCA1 BRWD1 CARM1 CBX5 CCNE1 CDK19 CDK8 CDKN2A CDX2 CEBPA CEBPB CHD4 CHMP5 CIITA CREB1 CTNNB1 DPF3 ESR1 ETS2 FANCA GATA1 GMNN H2AFX H3F3A HIST1H3A HIST1H4F HIST2H2BE HIST2H3C HSF1 HSF4 IKZF1 KLF1 MBD3 MDM2 MED17 MED6 MKL1 MPHOSPH6 MPP6 MYC MYOCD NR3C1 NR4A2 PABPN1 PAX6 PBRM1 PHB RAP1A RB1 RBL1 RBL2 RELB RFXAP SIN3A SIN3B SMARCB1 SMARCC1 SMARCE1 SS18 SS18L1 STAT2 STAT3 STK11 TMF1 TP53 ZMYND11
Entrez ID		57591	6597
HPRD ID		10445	04459
Ensembl ID		ENSG00000196588	ENSG00000127616
Uniprot IDs		Q969V6	A7E2E1 B3KNW7 P51532 Q9HBD4
PDB IDs		2KVU 2KW9	2GRC 2H60 3UVD
Enriched GO Terms of Interacting Partners?		Smooth Muscle Cell Differentiation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Beta-amyloid Clearance Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Peptidyl-lysine Modification Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Heart Development Regulation Of Beta-amyloid Clearance Muscle Cell Differentiation Regulation Of DNA Binding Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Regulation Of Transcription From RNA Polymerase II Promoter Blood Vessel Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Cardiac Muscle Cell Myoblast Differentiation Positive Regulation Of Metabolic Process Cardioblast Differentiation Negative Regulation Of Cellular Metabolic Process Cardiac Chamber Development Heart Trabecula Formation Muscle Structure Development Blood Vessel Development Regulation Of Smooth Muscle Cell Differentiation Heart Development Vasculature Development Vascular Smooth Muscle Cell Differentiation Positive Regulation Of Transcription, DNA-templated Cardiac Muscle Tissue Development Protein Sumoylation Positive Regulation Of Smooth Muscle Contraction Heart Trabecula Morphogenesis Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Heart Morphogenesis Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of DNA Binding Regulation Of Binding Developmental Growth Myoblast Differentiation Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Signaling Cardiovascular System Development Stem Cell Differentiation	Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Positive Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Chromosome Organization Cellular Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Modification Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Organelle Organization Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Chromatin Remodeling Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Regulation Of Cellular Process Intracellular Steroid Hormone Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Anatomical Structure Development Developmental Process Chromatin Assembly Or Disassembly System Development Multicellular Organismal Development ATP-dependent Chromatin Remodeling
Tagcloud ?		arise arises conditional disassembly disrupts emt epdc epdcs epicardial epicardium lining manipulate mesothelium microvascular mkl2 mobilization motile motility mrtf mrtfa mrtfb mrtfs myocardin pericytes perinuclear shed stemming sub tracing	abnormality arid1a coinactivation copyright fish frame harboring heterozygous infancy insights malignancies missense monoploid mrts pbrm1 protected remodeling reserved rhabdoid rights screened sense snf subunits swi trisomy truncating
Tagcloud (Difference) ?		arise arises conditional disassembly disrupts emt epdc epdcs epicardial epicardium lining manipulate mesothelium microvascular mkl2 mobilization motile motility mrtf mrtfa mrtfb mrtfs myocardin pericytes perinuclear shed stemming sub tracing	abnormality arid1a coinactivation copyright fish frame harboring heterozygous infancy insights malignancies missense monoploid mrts pbrm1 protected remodeling reserved rhabdoid rights screened sense snf subunits swi trisomy truncating
Tagcloud (Intersection) ?