MKL1 and KDM3A

Number of citations of the paper that reports this interaction (PMID 17991879)
29

Data Source:
BioGRID (pull down)

		MKL1	KDM3A
Gene Name		megakaryoblastic leukemia (translocation) 1	lysine (K)-specific demethylase 3A
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nucleus Nucleoplasm Cytoplasm Membrane
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Actin Binding Actin Monomer Binding Protein Binding Leucine Zipper Domain Binding	Transcription Regulatory Region Sequence-specific DNA Binding Core Promoter Binding Sequence-specific DNA Binding Transcription Factor Activity Iron Ion Binding Androgen Receptor Binding Dioxygenase Activity
	Biological Process	Transcription, DNA-templated Positive Regulation Of Transcription Via Serum Response Element Binding Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Smooth Muscle Cell Differentiation Negative Regulation Of Apoptotic Signaling Pathway	Chromatin Organization Transcription, DNA-templated Spermatid Nucleus Elongation Hormone-mediated Signaling Pathway Androgen Receptor Signaling Pathway Histone H3-K9 Demethylation Histone H3-K9 Dimethylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Formaldehyde Biosynthetic Process Negative Regulation Of Histone H3-K9 Methylation Oxidation-reduction Process
Pathways			Chromatin modifying enzymes Chromatin organization HDMs demethylate histones
Drugs
Diseases
GWAS		Breast cancer ( 23535729 23535733) Breast size ( 22747683) Height ( 19570815) Treatment response for severe sepsis ( 22310353)
Protein-Protein Interactions		8 interactors: KDM3A MKL2 MVP MYOCD SMARCA4 SRF SUMO1 UBE2I	6 interactors: ETV2 HIST2H3C MKL1 MKL2 MYOCD RIPK2
Entrez ID		57591	55818
HPRD ID		10445	11054
Ensembl ID		ENSG00000196588	ENSG00000115548
Uniprot IDs		Q969V6	Q9Y4C1
PDB IDs		2KVU 2KW9
Enriched GO Terms of Interacting Partners?		Smooth Muscle Cell Differentiation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Beta-amyloid Clearance Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Peptidyl-lysine Modification Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Heart Development Regulation Of Beta-amyloid Clearance Muscle Cell Differentiation Regulation Of DNA Binding Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Regulation Of Transcription From RNA Polymerase II Promoter Blood Vessel Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Cardiac Muscle Cell Myoblast Differentiation Positive Regulation Of Metabolic Process Cardioblast Differentiation Negative Regulation Of Cellular Metabolic Process Cardiac Chamber Development Heart Trabecula Formation Muscle Structure Development Blood Vessel Development Regulation Of Smooth Muscle Cell Differentiation Heart Development Vasculature Development Vascular Smooth Muscle Cell Differentiation Positive Regulation Of Transcription, DNA-templated Cardiac Muscle Tissue Development Protein Sumoylation Positive Regulation Of Smooth Muscle Contraction Heart Trabecula Morphogenesis Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Heart Morphogenesis Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of DNA Binding Regulation Of Binding Developmental Growth Myoblast Differentiation Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Signaling Cardiovascular System Development Stem Cell Differentiation	Smooth Muscle Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Muscle Cell Differentiation Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Striated Muscle Tissue Development Positive Regulation Of Muscle Tissue Development Blood Vessel Morphogenesis Muscle Structure Development Blood Vessel Development Vasculature Development Hepatic Stellate Cell Activation BMP Signaling Pathway Involved In Mesodermal Cell Fate Specification Positive Regulation Of Cardiac Vascular Smooth Muscle Cell Differentiation Positive Regulation Of Metabolic Process Gene Expression Regulation Of Striated Muscle Tissue Development Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Cellular Response To Muramyl Dipeptide Negative Regulation Of Beta-amyloid Clearance Response To Interleukin-18 Positive Regulation Of Cell Differentiation Cardiovascular System Development Cardiac Muscle Tissue Development Negative Regulation Of Skeletal Muscle Cell Differentiation Fibroblast Activation Regulation Of Cell Growth By Extracellular Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Smooth Muscle Cell Differentiation Regulation Of Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Transcription, DNA-templated Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Positive Regulation Of Mesoderm Development Urinary Bladder Development Positive Regulation Of Smooth Muscle Cell Differentiation Response To Interleukin-12 Negative Regulation Of Cell Death RNA Biosynthetic Process
Tagcloud ?		arise arises conditional disassembly disrupts emt epdc epdcs epicardial epicardium lining manipulate mesothelium microvascular mkl2 mobilization motile motility mrtf mrtfa mrtfb mrtfs myocardin pericytes perinuclear shed stemming sub tracing	1alpha 2alpha 6b catalyzes cocl2 demethylase demethylases demethylation desferrioxamine dimethylation elongation experiment h3k27 h3k27me3 hif hypoxia immunoprecipitation implies indicates kdm4b kdm4c kdm6b lysine mesylate mimic modestly o2 rnai tri
Tagcloud (Difference) ?		arise arises conditional disassembly disrupts emt epdc epdcs epicardial epicardium lining manipulate mesothelium microvascular mkl2 mobilization motile motility mrtf mrtfa mrtfb mrtfs myocardin pericytes perinuclear shed stemming sub tracing	1alpha 2alpha 6b catalyzes cocl2 demethylase demethylases demethylation desferrioxamine dimethylation elongation experiment h3k27 h3k27me3 hif hypoxia immunoprecipitation implies indicates kdm4b kdm4c kdm6b lysine mesylate mimic modestly o2 rnai tri
Tagcloud (Intersection) ?