MRTFA and KDM3A

Number of citations of the paper that reports this interaction (PubMedID 17991879)
0

Data Source:
BioGRID (pull down)

		MRTFA	KDM3A
Description		myocardin related transcription factor A	lysine demethylase 3A
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Histone Deacetylase Complex Chromatin Male Germ Cell Nucleus Nucleus Nucleoplasm Cytoplasm Membrane
	Molecular Function	Transcription Coactivator Activity Actin Binding Actin Monomer Binding Protein Binding Leucine Zipper Domain Binding	Chromatin Binding Transcription Coregulator Activity Iron Ion Binding Protein Binding Zinc Ion Binding Oxidoreductase Activity Chromatin DNA Binding Histone H3K9 Demethylase Activity Metal Ion Binding Nuclear Androgen Receptor Binding Dioxygenase Activity Histone H3K9me/H3K9me2 Demethylase Activity
	Biological Process	Actin Cytoskeleton Organization Wound Healing, Spreading Of Cells Positive Regulation Of Transcription By RNA Polymerase II Smooth Muscle Cell Differentiation Positive Regulation Of MiRNA Transcription	Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Spermatogenesis Spermatid Nucleus Elongation Hormone-mediated Signaling Pathway Regulation Of Gene Expression Cell Differentiation Androgen Receptor Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Formaldehyde Biosynthetic Process Positive Regulation Of Cold-induced Thermogenesis Cellular Response To Leukemia Inhibitory Factor Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Differentiation
Pathways		SUMOylation of transcription cofactors RHO GTPases Activate Formins	HDMs demethylate histones NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs		Latrunculin B
Diseases
GWAS		Appendicular lean mass ( 33097823)	Atrial fibrillation ( 29892015) Glomerular filtration rate in chronic kidney disease ( 26420894) Ovarian cancer ( 30557369)
Interacting Genes		12 interacting genes: KDM3A MAP1LC3A MAP1LC3B MRTFB MVP MYOCD NCOA3 SMARCA4 SRF SUMO1 TRIM54 UBE2I	7 interacting genes: BTG3 ETV2 H3C14 MRTFA MRTFB MYOCD RIPK2
Entrez ID		57591	55818
HPRD ID		10445	11054
Ensembl ID		ENSG00000196588	ENSG00000115548
Uniprot IDs		A0A494BZX7 A0A499FIJ6 A4FUJ8 B0QY83 Q969V6 W0Z7M9	Q9Y4C1
PDB IDs		2KVU 2KW9
Enriched GO Terms of Interacting Partners?		Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of MiRNA Transcription Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Smooth Muscle Cell Differentiation Cardiac Vascular Smooth Muscle Cell Differentiation Small Protein Activating Enzyme Binding Regulation Of Stem Cell Population Maintenance Vascular Associated Smooth Muscle Cell Differentiation Negative Regulation Of Amyloid-beta Clearance Cardiac Muscle Cell Myoblast Differentiation Nuclear Pore Cellular Response To Nitrogen Starvation Transcription Coactivator Activity Cardioblast Differentiation Phosphatidylethanolamine Binding Regulation Of Transcription By RNA Polymerase II Muscle Cell Differentiation Regulation Of Amyloid-beta Clearance Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Disassembly Nuclear Androgen Receptor Binding Presynaptic Cytosol Postsynaptic Cytosol Positive Regulation Of Smooth Muscle Contraction Regulation Of Muscle Contraction Myoblast Differentiation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Coregulator Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of DNA-templated Transcription Regulation Of Smooth Muscle Cell Differentiation Glutamatergic Synapse Organelle Membrane Cardiocyte Differentiation Positive Regulation Of Stem Cell Population Maintenance Chromatin Positive Regulation Of Muscle Contraction Autophagosome Maturation Regulation Of RNA Metabolic Process Transcription Initiation-coupled Chromatin Remodeling Regulation Of Muscle System Process Protein Sumoylation Positive Regulation Of Gene Expression, Epigenetic Serum Response Element Binding Cellular Response To Nutrient Levels SUMO Conjugating Enzyme Activity	Smooth Muscle Cell Differentiation Positive Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Metabolic Process Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Muscle Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription Coactivator Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Blood Vessel Morphogenesis Positive Regulation Of Developmental Process Positive Regulation Of Mesoderm Development Positive Regulation Of Macromolecule Biosynthetic Process Response To Interleukin-18 Regulation Of Cell Growth By Extracellular Stimulus Positive Regulation Of Biosynthetic Process Response To Interleukin-12 Cardiac Vascular Smooth Muscle Cell Differentiation Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Urinary Bladder Development Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Regulation Of Mesoderm Development Positive Regulation Of T-helper 1 Cell Differentiation Toll-like Receptor 2 Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway LIM Domain Binding Cellular Response To Peptidoglycan Immature T Cell Proliferation In Thymus Xenophagy Positive Regulation Of Immature T Cell Proliferation In Thymus Protein Linear Polyubiquitination Ventricular Cardiac Muscle Cell Differentiation Negative Regulation Of Skeletal Muscle Cell Differentiation Cardiac Ventricle Development Ductus Arteriosus Closure Regulation Of Phenotypic Switching Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Xenophagy Positive Regulation Of Protein K63-linked Ubiquitination Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
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