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IL7R and STAT5A
Number of citations of the paper that reports this interaction (PubMedID
7719938
)
0
Data Source:
HPRD
(in vivo)
IL7R
STAT5A
Description
interleukin 7 receptor
signal transducer and activator of transcription 5A
Image
GO Annotations
Cellular Component
Extracellular Region
Nucleoplasm
Cytosol
Plasma Membrane
External Side Of Plasma Membrane
Membrane
Clathrin-coated Endocytic Vesicle Membrane
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
RNA Polymerase II Transcription Regulator Complex
Molecular Function
Antigen Binding
Cytokine Receptor Activity
Interleukin-7 Receptor Activity
Protein Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Phosphate Ion Binding
Sequence-specific DNA Binding
DNA-binding Transcription Factor Binding
Biological Process
Regulation Of DNA Recombination
Cell Morphogenesis
B Cell Homeostasis
T Cell Mediated Cytotoxicity
Negative Regulation Of T Cell Mediated Cytotoxicity
Immune Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Regulation Of Cell Size
Gene Expression
Positive Regulation Of Gene Expression
Cytokine-mediated Signaling Pathway
Cellular Homeostasis
Hemopoiesis
T Cell Differentiation
T Cell Differentiation In Thymus
Positive Regulation Of T Cell Differentiation In Thymus
Interleukin-7-mediated Signaling Pathway
B Cell Proliferation
T Cell Homeostasis
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Lymph Node Development
Defense Response To Gram-positive Bacterium
Negative Regulation Of T Cell Apoptotic Process
Positive Regulation Of Receptor Signaling Pathway Via STAT
Mitotic Cell Cycle
Luteinization
Natural Killer Cell Differentiation
Positive Regulation Of Endothelial Cell Proliferation
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Defense Response
Signal Transduction
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Female Pregnancy
Lactation
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Regulation Of Steroid Metabolic Process
Cytokine-mediated Signaling Pathway
Taurine Metabolic Process
Lipid Storage
Lymphocyte Differentiation
Regulation Of Cell Adhesion
B Cell Differentiation
Erythrocyte Differentiation
Eosinophil Differentiation
Regulation Of Epithelial Cell Differentiation
Mammary Gland Development
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Natural Killer Cell Differentiation
Mast Cell Apoptotic Process
Negative Regulation Of Mast Cell Apoptotic Process
Myeloid Cell Apoptotic Process
Negative Regulation Of Myeloid Cell Apoptotic Process
T Cell Differentiation In Thymus
Interleukin-15-mediated Signaling Pathway
Interleukin-4-mediated Signaling Pathway
Reelin-mediated Signaling Pathway
Interleukin-5-mediated Signaling Pathway
Interleukin-2-mediated Signaling Pathway
Interleukin-7-mediated Signaling Pathway
Interleukin-9-mediated Signaling Pathway
Interleukin-3-mediated Signaling Pathway
Thrombopoietin-mediated Signaling Pathway
Regulation Of Multicellular Organism Growth
Positive Regulation Of Multicellular Organism Growth
T Cell Proliferation
Positive Regulation Of T Cell Proliferation
Positive Regulation Of Activated T Cell Proliferation
Regulation Of Cell Population Proliferation
Natural Killer Cell Mediated Cytotoxicity
Gamma-delta T Cell Differentiation
T Cell Homeostasis
Response To Peptide Hormone
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of B Cell Differentiation
Positive Regulation Of Gamma-delta T Cell Differentiation
Positive Regulation Of Lymphocyte Differentiation
Negative Regulation Of Erythrocyte Differentiation
Positive Regulation Of Mitotic Cell Cycle
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
Development Of Secondary Female Sexual Characteristics
Development Of Secondary Male Sexual Characteristics
Peyer's Patch Development
Positive Regulation Of Inflammatory Response
Activated T Cell Proliferation
Mast Cell Differentiation
Positive Regulation Of Mast Cell Differentiation
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Prostate Gland Epithelium Morphogenesis
Epithelial Cell Differentiation Involved In Prostate Gland Development
Mammary Gland Epithelium Development
Mast Cell Proliferation
Positive Regulation Of Mast Cell Proliferation
Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus
Regulation Of Hemopoiesis
Negative Regulation Of T-helper 17 Cell Lineage Commitment
Pathways
Interleukin-7 signaling
Interleukin-7 signaling
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Prolactin receptor signaling
Nuclear signaling by ERBB4
Interleukin-7 signaling
Interleukin-7 signaling
Signaling by SCF-KIT
Signaling by cytosolic FGFR1 fusion mutants
Downstream signal transduction
Signaling by Leptin
Interleukin-3, Interleukin-5 and GM-CSF signaling
Interleukin-3, Interleukin-5 and GM-CSF signaling
Interleukin-20 family signaling
Interleukin-15 signaling
Interleukin-9 signaling
Interleukin-2 signaling
Interleukin-2 signaling
Interleukin-21 signaling
Erythropoietin activates STAT5
STAT5 Activation
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by CSF3 (G-CSF)
STAT5 activation downstream of FLT3 ITD mutants
Signaling by FLT3 fusion proteins
Inactivation of CSF3 (G-CSF) signaling
Nuclear events stimulated by ALK signaling in cancer
Growth hormone receptor signaling
Growth hormone receptor signaling
Drugs
Diseases
T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS
Allergic disease (asthma, hay fever or eczema) (
29785011
29083406
)
Allergic rhinitis (
31361310
30013184
)
Ankylosing spondylitis (
23749187
)
Asthma (
34103634
32296059
31619474
31361310
30929738
)
Asthma (adult onset) (
30929738
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Atopic dermatitis (
26482879
)
Basophil percentage of white cells (
32888494
)
Blood protein levels (
30072576
)
Eczema (
31361310
)
Lymphocyte count (
27863252
32888494
)
Lymphocyte percentage of white cells (
27863252
32888494
)
Medication use (adrenergics, inhalants) (
31015401
)
Monocyte percentage of white cells (
32888494
)
Multiple sclerosis (
31604244
21244703
19525953
21833088
24076602
)
Neutrophil percentage of white cells (
27863252
32888494
)
Primary biliary cholangitis (
26394269
21399635
30643196
23000144
28062665
)
Primary biliary cirrhosis (
22961000
)
Systemic lupus erythematosus (
33536424
)
Type 1 diabetes (
25751624
17554260
)
Ulcerative colitis (
21297633
)
White blood cell count (
32888494
)
Asthma (childhood onset) (
31036433
)
Crohn's disease (
28067908
)
Heel bone mineral density (
30598549
)
Inflammatory bowel disease (
23128233
27569725
28067908
)
Low density lipoprotein cholesterol levels (
32154731
)
Ulcerative colitis (
28067908
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Interacting Genes
110 interacting genes:
AGTRAP
ALYREF
APOL3
CIRBP
CPSF1
CRLF2
DDX21
DDX39B
DDX3X
DDX5
DHX36
DHX9
EIF2AK2
ELAVL1
EMG1
FAU
FUS
FYN
G3BP1
H1-10
H1-2
H1-4
H2BC21
HNRNPA0
HNRNPA3
HNRNPAB
HNRNPC
HNRNPD
HNRNPDL
HNRNPH3
HNRNPL
HNRNPR
HNRNPU
HNRNPUL1
HNRNPUL2
IL2RG
IL7
ILF2
ILF3
JAK1
JAK3
KIT
LYN
MALL
MAP4
MS4A1
NCL
NONO
PABPC1
PABPC4
PABPN1
PIK3R1
PTBP1
PTK2B
PTMA
PURA
PURB
QKI
RACK1
RAD21
RBM3
RBMX
RPL15
RPL18
RPL22
RPL29
RPL30
RPL31
RPL6
RPL7
RPL8
RPS20
RPS3
RPSA
RRAGA
RSL1D1
SAFB
SDC4
SF1
SF3A1
SF3B1
SNRNP70
SNRPA
SNRPB
SNRPD1
SNRPD2
SNRPD3
SNRPE
SNRPF
SNRPG
SRP14
SRP9
SRSF3
SRSF9
SSB
STAT3
STAT5A
STAT5B
SYNCRIP
TMEM120B
TOE1
TOP1
TSLP
U2AF1
U2AF2
YBX1
YBX3
YWHAE
YWHAG
ZNF787
72 interacting genes:
AQP11
BMX
BRCA1
BRCA2
BTK
CBL
CCR5
CD247
CEBPB
CPAP
CRK
CRKL
CSNK2B
CTLA4
CYP2C9
EGFR
EP300
EPAS1
EPOR
ERBB4
ESR1
ESR2
FBXW7
FN1
GHR
GLUD1
GNB2
HELZ
IL2RB
IL2RG
IL7R
INSR
JAK1
JAK2
JAK3
KIT
LCK
MAGEA12
MAPK1
MAPK3
MRPS6
NCOR2
NMI
NR3C1
OLIG1
PDGFRA
PDGFRB
POM121C
POU2F1
PPIB
PPP2CA
PRMT1
PRTFDC1
PTPN1
PTPN11
PTPN2
RBMX
SHC1
SRC
STAP2
STAT1
STAT3
STAT5B
SYK
TCF12
TEK
TET2
TSLP
TXNDC11
UGT2B4
WASH2P
ZNF596
Entrez ID
3575
6776
HPRD ID
00893
03301
Ensembl ID
ENSG00000168685
ENSG00000126561
Uniprot IDs
P16871
A0A384N5W4
A0A7I2YQF1
A8K6I5
K7EK35
P42229
Q59GY7
PDB IDs
3DI2
3DI3
3UP1
5J11
6P50
6P67
7OPB
7TVA
7TVB
7UBT
7UC6
7UC7
Enriched GO Terms of Interacting Partners
?
RNA Binding
Ribonucleoprotein Complex
Nucleic Acid Binding
RNA Processing
MRNA Processing
RNA Splicing
Spliceosomal Complex
MRNA Metabolic Process
MRNA Splicing, Via Spliceosome
RNA Splicing, Via Transesterification Reactions
RNA Metabolic Process
MRNA Binding
Nucleus
Catalytic Step 2 Spliceosome
Nucleic Acid Metabolic Process
Regulation Of MRNA Metabolic Process
Macromolecule Metabolic Process
Negative Regulation Of MRNA Metabolic Process
Nucleoplasm
Nucleobase-containing Compound Metabolic Process
Post-transcriptional Regulation Of Gene Expression
Negative Regulation Of RNA Catabolic Process
Positive Regulation Of Gene Expression
Cytoplasmic Translation
Negative Regulation Of MRNA Catabolic Process
RNA Stabilization
Spliceosomal Complex Assembly
Regulation Of Translation
MRNA Stabilization
Regulation Of MRNA Processing
U4 SnRNP
U1 SnRNP
7-methylguanosine Cap Hypermethylation
U12-type Spliceosomal Complex
U2-type Prespliceosome Assembly
Cytosolic Ribosome
Regulation Of RNA Splicing
Negative Regulation Of Translation
U2 SnRNP
Positive Regulation Of Translation
Ribosome
Positive Regulation Of Cytoplasmic Translation
Regulation Of MRNA Stability
U2-type Spliceosomal Complex
Protein-RNA Complex Assembly
Methylosome
Regulation Of MRNA Splicing, Via Spliceosome
Regulation Of RNA Stability
Negative Regulation Of Gene Expression
Regulation Of Gene Expression
Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Protein Tyrosine Kinase Activity
Enzyme-linked Receptor Protein Signaling Pathway
Cytokine-mediated Signaling Pathway
Signal Transduction
Regulation Of MAPK Cascade
Regulation Of Cell Population Proliferation
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of MAPK Cascade
Positive Regulation Of Intracellular Signal Transduction
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Peptidyl-tyrosine Phosphorylation
Cell Surface Receptor Signaling Pathway Via STAT
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Interleukin-7-mediated Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Regulation Of Immune System Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Receptor Signaling Pathway Via STAT
Phosphorylation
Phosphotyrosine Residue Binding
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Regulation Of Developmental Process
Animal Organ Development
Regulation Of ERK1 And ERK2 Cascade
Protein Phosphorylation
Regulation Of Multicellular Organismal Process
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Signal Transduction
Developmental Process
Response To Growth Factor
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Growth Hormone Receptor Signaling Pathway
Positive Regulation Of Macromolecule Metabolic Process
Non-membrane Spanning Protein Tyrosine Kinase Activity
Regulation Of Macromolecule Biosynthetic Process
Protein Kinase Activity
Regulation Of Gene Expression
Regulation Of Immune Response
Identical Protein Binding
Positive Regulation Of Metabolic Process
Regulation Of Signaling
Regulation Of Cell Communication
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