IL7R and G3BP1

Number of citations of the paper that reports this interaction (PMID 23151878)
3

Data Source:
BioGRID (unspecified method)

		IL7R	G3BP1
Gene Name		interleukin 7 receptor	GTPase activating protein (SH3 domain) binding protein 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Cytoplasmic Stress Granule
	Molecular Function	Antigen Binding Interleukin-7 Receptor Activity Protein Binding	DNA Binding MRNA Binding ATP-dependent DNA Helicase Activity ATP-dependent RNA Helicase Activity Endonuclease Activity Protein Binding ATP Binding Poly(A) RNA Binding
	Biological Process	Regulation Of DNA Recombination Cell Morphogenesis Negative Regulation Of T Cell Mediated Cytotoxicity Immunoglobulin Production Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Cell Size Positive Regulation Of Gene Expression Cell Growth T Cell Differentiation Positive Regulation Of T Cell Differentiation In Thymus Interleukin-7-mediated Signaling Pathway B Cell Proliferation Lymph Node Development Homeostasis Of Number Of Cells	Transport Ras Protein Signal Transduction Metabolic Process DNA Duplex Unwinding Negative Regulation Of Canonical Wnt Signaling Pathway Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		Signaling by Interleukins Interleukin-7 signaling Cytokine Signaling in Immune system
Drugs
Diseases
GWAS		Multiple sclerosis ( 21244703 19525953 21833088) Primary biliary cirrhosis ( 23000144 21399635) Type 1 diabetes ( 17554260) Ulcerative colitis ( 21297633)
Protein-Protein Interactions		104 interactors: ALYREF CIRBP CPSF1 CRLF2 DDX21 DDX39B DDX3X DDX5 DHX36 DHX9 EIF2AK2 ELAVL1 EMG1 FAU FUS FYN G3BP1 GNB2L1 H1FX HIST1H1C HIST1H1E HIST2H2BE HNRNPA0 HNRNPA3 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPH3 HNRNPL HNRNPR HNRNPU HNRNPUL1 HNRNPUL2 IL2RG IL7 ILF2 ILF3 JAK1 JAK3 KIT LYN MAP4 NCL NONO PABPC1 PABPC4 PABPN1 PIK3R1 PTBP1 PTK2B PTMA PURA PURB QKI RAD21 RBM3 RBMX RPL15 RPL18 RPL22 RPL29 RPL30 RPL31 RPL6 RPL7 RPL8 RPS20 RPS3 RPSA RRAGA RSL1D1 SAFB SF1 SF3A1 SF3B1 SNRNP70 SNRPA SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SRP14 SRP9 SRSF3 SRSF9 SSB STAT3 STAT5A STAT5B SYNCRIP TOE1 TOP1 TSLP U2AF1 U2AF2 YBX1 YBX3 YWHAE YWHAG ZNF787	11 interactors: APP CSK DTX1 EPHA8 FBXO25 HDAC6 IL7R LCK PIN1 RASA1 USP10
Entrez ID		3575	10146
HPRD ID		00893	06569
Ensembl ID		ENSG00000168685	ENSG00000145907
Uniprot IDs		D6RGV2 D9N160 P16871	Q13283 Q5HYE9 Q5U0Q1 Q6ZP53
PDB IDs		3DI2 3DI3 3UP1	3Q90 4FCJ 4FCM
Enriched GO Terms of Interacting Partners?		MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing RNA Splicing MRNA Processing RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Viral Process RNA Biosynthetic Process SRP-dependent Cotranslational Protein Targeting To Membrane Termination Of RNA Polymerase II Transcription Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Cellular Macromolecule Biosynthetic Process Regulation Of MRNA Stability Regulation Of RNA Stability Macromolecule Biosynthetic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Protein Localization To Endoplasmic Reticulum Viral Life Cycle Cytoplasmic Transport Posttranscriptional Regulation Of Gene Expression MRNA Stabilization RNA 3'-end Processing MRNA 3'-end Processing RNA Catabolic Process Viral Transcription Cellular Metabolic Process Protein Targeting To Membrane DNA-templated Transcription, Termination Protein Targeting Nuclear-transcribed MRNA Catabolic Process Establishment Of Protein Localization To Organelle MRNA Catabolic Process Ribonucleoprotein Complex Assembly Regulation Of Translation Ribonucleoprotein Complex Biogenesis Biosynthetic Process Protein Localization To Organelle Translational Termination Establishment Of Protein Localization To Membrane Intracellular Transport Translational Elongation	Regulation Of Cell Adhesion Cellular Protein Modification Process Regulation Of Signal Transduction Cell Communication Regulation Of T Cell Activation Neuron Remodeling Cellular Protein Metabolic Process Regulation Of Signaling Cell Surface Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Positive Regulation Of Metabolic Process Regulation Of Lymphocyte Activation Regulation Of T Cell Differentiation Cellular Response To Stimulus Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Peptidyl-amino Acid Modification Regulation Of Lymphocyte Differentiation Regulation Of Cell Activation Signal Transduction Protein Metabolic Process Regulation Of Metabolic Process Signaling Platelet Activation Neuron Maturation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of T Cell Activation Protein Autophosphorylation Positive Regulation Of Homotypic Cell-cell Adhesion Locomotion Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cell-cell Adhesion Immune Response Regulation Of Proteolysis Regulation Of Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Stimulus Regulation Of Protein Metabolic Process Cell Activation Cell Differentiation Peptidyl-tyrosine Phosphorylation Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cell Activation Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Innate Immune Response Regulation Of Cell Differentiation Positive Regulation Of Phosphorylation Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death
Tagcloud ?		aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1	blockade bolster capsid counters cyclophilin cypa defences disassembles displacing eef2 gag groundwork imposed infectivity lay lifts loops overexposed preformed recruiting sg sgs sh3 silent stabilizes tiar translationally triage unsuspected
Tagcloud (Difference) ?		aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1	blockade bolster capsid counters cyclophilin cypa defences disassembles displacing eef2 gag groundwork imposed infectivity lay lifts loops overexposed preformed recruiting sg sgs sh3 silent stabilizes tiar translationally triage unsuspected
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