IL7R and RPS3

Number of citations of the paper that reports this interaction (PMID 23151878)
3

Data Source:
BioGRID (unspecified method)

		IL7R	RPS3
Gene Name		interleukin 7 receptor	ribosomal protein S3
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Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane	Nucleus Nucleolus Cytoplasm Mitochondrial Inner Membrane Spindle Cytosol Focal Adhesion Membrane Cytosolic Small Ribosomal Subunit Ribonucleoprotein Complex Ruffle Membrane Extracellular Vesicular Exosome NF-kappaB Complex
	Molecular Function	Antigen Binding Interleukin-7 Receptor Activity Protein Binding	Damaged DNA Binding MRNA Binding Structural Constituent Of Ribosome DNA-(apurinic Or Apyrimidinic Site) Lyase Activity Protein Binding Oxidized Purine Nucleobase Lesion DNA N-glycosylase Activity Enzyme Binding Protein Kinase Binding Poly(A) RNA Binding Protein Kinase A Binding NF-kappaB Binding Iron-sulfur Cluster Binding
	Biological Process	Regulation Of DNA Recombination Cell Morphogenesis Negative Regulation Of T Cell Mediated Cytotoxicity Immunoglobulin Production Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Cell Size Positive Regulation Of Gene Expression Cell Growth T Cell Differentiation Positive Regulation Of T Cell Differentiation In Thymus Interleukin-7-mediated Signaling Pathway B Cell Proliferation Lymph Node Development Homeostasis Of Number Of Cells	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay DNA Catabolic Process, Endonucleolytic Cytoplasmic Translation DNA Repair Transcription, DNA-templated Translation Translational Initiation Translational Elongation Translational Termination Regulation Of Translation SRP-dependent Cotranslational Protein Targeting To Membrane Apoptotic Process Cellular Response To DNA Damage Stimulus Mitotic Nuclear Division Gene Expression Viral Process Viral Life Cycle Viral Transcription Cellular Protein Metabolic Process Negative Regulation Of DNA Repair Positive Regulation Of NF-kappaB Transcription Factor Activity Cell Division Positive Regulation Of DNA N-glycosylase Activity Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Signaling by Interleukins Interleukin-7 signaling Cytokine Signaling in Immune system	Nonsense-Mediated Decay (NMD) Translation initiation complex formation Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosomal scanning and start codon recognition Formation of the ternary complex, and subsequently, the 43S complex Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Multiple sclerosis ( 21244703 19525953 21833088) Primary biliary cirrhosis ( 23000144 21399635) Type 1 diabetes ( 17554260) Ulcerative colitis ( 21297633)
Protein-Protein Interactions		104 interactors: ALYREF CIRBP CPSF1 CRLF2 DDX21 DDX39B DDX3X DDX5 DHX36 DHX9 EIF2AK2 ELAVL1 EMG1 FAU FUS FYN G3BP1 GNB2L1 H1FX HIST1H1C HIST1H1E HIST2H2BE HNRNPA0 HNRNPA3 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPH3 HNRNPL HNRNPR HNRNPU HNRNPUL1 HNRNPUL2 IL2RG IL7 ILF2 ILF3 JAK1 JAK3 KIT LYN MAP4 NCL NONO PABPC1 PABPC4 PABPN1 PIK3R1 PTBP1 PTK2B PTMA PURA PURB QKI RAD21 RBM3 RBMX RPL15 RPL18 RPL22 RPL29 RPL30 RPL31 RPL6 RPL7 RPL8 RPS20 RPS3 RPSA RRAGA RSL1D1 SAFB SF1 SF3A1 SF3B1 SNRNP70 SNRPA SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SRP14 SRP9 SRSF3 SRSF9 SSB STAT3 STAT5A STAT5B SYNCRIP TOE1 TOP1 TSLP U2AF1 U2AF2 YBX1 YBX3 YWHAE YWHAG ZNF787	14 interactors: ATP6V0D2 CCT2 CSNK2A1 FOLH1 HSP90AA1 IL7R MDM2 NDRG1 NFKB1 RELA RPL9 SUMO1 TP53 YWHAQ
Entrez ID		3575	6188
HPRD ID		00893	10941
Ensembl ID		ENSG00000168685	ENSG00000149273
Uniprot IDs		D6RGV2 D9N160 P16871	P23396
PDB IDs		3DI2 3DI3 3UP1	1WH9 3J3A
Enriched GO Terms of Interacting Partners?		MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing RNA Splicing MRNA Processing RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Viral Process RNA Biosynthetic Process SRP-dependent Cotranslational Protein Targeting To Membrane Termination Of RNA Polymerase II Transcription Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Cellular Macromolecule Biosynthetic Process Regulation Of MRNA Stability Regulation Of RNA Stability Macromolecule Biosynthetic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Protein Localization To Endoplasmic Reticulum Viral Life Cycle Cytoplasmic Transport Posttranscriptional Regulation Of Gene Expression MRNA Stabilization RNA 3'-end Processing MRNA 3'-end Processing RNA Catabolic Process Viral Transcription Cellular Metabolic Process Protein Targeting To Membrane DNA-templated Transcription, Termination Protein Targeting Nuclear-transcribed MRNA Catabolic Process Establishment Of Protein Localization To Organelle MRNA Catabolic Process Ribonucleoprotein Complex Assembly Regulation Of Translation Ribonucleoprotein Complex Biogenesis Biosynthetic Process Protein Localization To Organelle Translational Termination Establishment Of Protein Localization To Membrane Intracellular Transport Translational Elongation	Cellular Response To Alkaloid Immune Response Positive Regulation Of MiRNA Metabolic Process Membrane Organization Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Protein Localization To Organelle Immune System Process Cellular Response To Nicotine Signal Transduction DNA Damage Response, Signal Transduction By P53 Class Mediator Cell Surface Receptor Signaling Pathway Fc Receptor Signaling Pathway Regulation Of MiRNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Response To Abiotic Stimulus Signal Transduction In Response To DNA Damage Regulation Of Interleukin-12 Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Signaling Cellular Response To Hypoxia Cellular Response To Peptide Hormone Stimulus Response To Organic Substance Cellular Response To Decreased Oxygen Levels Chaperone-mediated Protein Complex Assembly Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Communication Cellular Response To Peptide Cellular Response To Oxygen Levels Signal Transduction By P53 Class Mediator Cellular Response To Organic Substance Protein Localization Membrane Protein Intracellular Domain Proteolysis Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Negative Regulation Of Gene Expression Response To UV Regulation Of Protein Catabolic Process Negative Regulation Of Biosynthetic Process Cellular Protein Localization Innate Immune Response Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Response To Alkaloid Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Response To Oxidative Stress Protein Targeting Regulation Of Apoptotic Process
Tagcloud ?		aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1	apocytochrome infa l20 l22 l33 liverwort marchantia peta petb petd preprotein psbb psbe psbf psbh rpl14 rpl16 rpl2 rpl20 rpl22 rpl23 rpl33 rpoa rps11 rps12 rps18 rps8 secx ugg
Tagcloud (Difference) ?		aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1	apocytochrome infa l20 l22 l33 liverwort marchantia peta petb petd preprotein psbb psbe psbf psbh rpl14 rpl16 rpl2 rpl20 rpl22 rpl23 rpl33 rpoa rps11 rps12 rps18 rps8 secx ugg
Tagcloud (Intersection) ?