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IL7R and RRAGA
Number of citations of the paper that reports this interaction (PubMedID
23151878
)
60
Data Source:
BioGRID
(unspecified method)
IL7R
RRAGA
Description
interleukin 7 receptor
Ras related GTP binding A
Image
GO Annotations
Cellular Component
Extracellular Region
Nucleoplasm
Cytosol
Plasma Membrane
External Side Of Plasma Membrane
Membrane
Clathrin-coated Endocytic Vesicle Membrane
Nucleus
Nucleoplasm
Cytoplasm
Lysosome
Lysosomal Membrane
Cytosol
Membrane
GATOR1 Complex
Gtr1-Gtr2 GTPase Complex
FNIP-folliculin RagC/D GAP
Molecular Function
Antigen Binding
Cytokine Receptor Activity
Interleukin-7 Receptor Activity
Protein Binding
Nucleotide Binding
GTPase Activity
Protein Binding
GTP Binding
Hydrolase Activity
Ubiquitin Protein Ligase Binding
Protein Homodimerization Activity
Protein-membrane Adaptor Activity
Protein Heterodimerization Activity
Phosphoprotein Binding
Biological Process
Regulation Of DNA Recombination
Cell Morphogenesis
B Cell Homeostasis
T Cell Mediated Cytotoxicity
Negative Regulation Of T Cell Mediated Cytotoxicity
Immune Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Regulation Of Cell Size
Gene Expression
Positive Regulation Of Gene Expression
Cytokine-mediated Signaling Pathway
Cellular Homeostasis
Hemopoiesis
T Cell Differentiation
T Cell Differentiation In Thymus
Positive Regulation Of T Cell Differentiation In Thymus
Interleukin-7-mediated Signaling Pathway
B Cell Proliferation
T Cell Homeostasis
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Lymph Node Development
Defense Response To Gram-positive Bacterium
Negative Regulation Of T Cell Apoptotic Process
Positive Regulation Of Receptor Signaling Pathway Via STAT
Autophagosome Assembly
Cytoplasmic Translation
Apoptotic Process
Intracellular Protein Localization
Cellular Response To Starvation
Negative Regulation Of Autophagy
Cellular Response To Nutrient Levels
Positive Regulation Of TOR Signaling
Tumor Necrosis Factor-mediated Signaling Pathway
Cellular Response To Amino Acid Starvation
Intracellular Signal Transduction
TORC1 Signaling
Glucose Homeostasis
Negative Regulation Of Translational Initiation
Positive Regulation Of Translational Initiation
Cellular Response To Methionine
Protein Localization To Lysosome
Cellular Response To Amino Acid Stimulus
Protein Localization To Membrane
Positive Regulation Of TORC1 Signaling
Pathways
Interleukin-7 signaling
Interleukin-7 signaling
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Macroautophagy
MTOR signalling
mTORC1-mediated signalling
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
E3 ubiquitin ligases ubiquitinate target proteins
Regulation of PTEN gene transcription
Amino acids regulate mTORC1
Drugs
Diseases
T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS
Allergic disease (asthma, hay fever or eczema) (
29785011
29083406
)
Allergic rhinitis (
31361310
30013184
)
Ankylosing spondylitis (
23749187
)
Asthma (
34103634
32296059
31619474
31361310
30929738
)
Asthma (adult onset) (
30929738
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Atopic dermatitis (
26482879
)
Basophil percentage of white cells (
32888494
)
Blood protein levels (
30072576
)
Eczema (
31361310
)
Lymphocyte count (
27863252
32888494
)
Lymphocyte percentage of white cells (
27863252
32888494
)
Medication use (adrenergics, inhalants) (
31015401
)
Monocyte percentage of white cells (
32888494
)
Multiple sclerosis (
31604244
21244703
19525953
21833088
24076602
)
Neutrophil percentage of white cells (
27863252
32888494
)
Primary biliary cholangitis (
26394269
21399635
30643196
23000144
28062665
)
Primary biliary cirrhosis (
22961000
)
Systemic lupus erythematosus (
33536424
)
Type 1 diabetes (
25751624
17554260
)
Ulcerative colitis (
21297633
)
White blood cell count (
32888494
)
Interacting Genes
110 interacting genes:
AGTRAP
ALYREF
APOL3
CIRBP
CPSF1
CRLF2
DDX21
DDX39B
DDX3X
DDX5
DHX36
DHX9
EIF2AK2
ELAVL1
EMG1
FAU
FUS
FYN
G3BP1
H1-10
H1-2
H1-4
H2BC21
HNRNPA0
HNRNPA3
HNRNPAB
HNRNPC
HNRNPD
HNRNPDL
HNRNPH3
HNRNPL
HNRNPR
HNRNPU
HNRNPUL1
HNRNPUL2
IL2RG
IL7
ILF2
ILF3
JAK1
JAK3
KIT
LYN
MALL
MAP4
MS4A1
NCL
NONO
PABPC1
PABPC4
PABPN1
PIK3R1
PTBP1
PTK2B
PTMA
PURA
PURB
QKI
RACK1
RAD21
RBM3
RBMX
RPL15
RPL18
RPL22
RPL29
RPL30
RPL31
RPL6
RPL7
RPL8
RPS20
RPS3
RPSA
RRAGA
RSL1D1
SAFB
SDC4
SF1
SF3A1
SF3B1
SNRNP70
SNRPA
SNRPB
SNRPD1
SNRPD2
SNRPD3
SNRPE
SNRPF
SNRPG
SRP14
SRP9
SRSF3
SRSF9
SSB
STAT3
STAT5A
STAT5B
SYNCRIP
TMEM120B
TOE1
TOP1
TSLP
U2AF1
U2AF2
YBX1
YBX3
YWHAE
YWHAG
ZNF787
5 interacting genes:
DYNLT1
FLCN
IL7R
NOL8
RRAGC
Entrez ID
3575
10670
HPRD ID
00893
10205
Ensembl ID
ENSG00000168685
ENSG00000155876
Uniprot IDs
P16871
Q7L523
PDB IDs
3DI2
3DI3
3UP1
5J11
6P50
6P67
7OPB
5X6V
6CES
6EHR
6NZD
6S6A
6S6D
6SB0
6SB2
6U62
6ULG
6WJ2
6WJ3
7T3A
7T3B
7T3C
7UX2
7UXC
7UXH
8DHB
Enriched GO Terms of Interacting Partners
?
RNA Binding
Ribonucleoprotein Complex
Nucleic Acid Binding
RNA Processing
MRNA Processing
RNA Splicing
Spliceosomal Complex
MRNA Metabolic Process
MRNA Splicing, Via Spliceosome
RNA Splicing, Via Transesterification Reactions
RNA Metabolic Process
MRNA Binding
Nucleus
Catalytic Step 2 Spliceosome
Nucleic Acid Metabolic Process
Regulation Of MRNA Metabolic Process
Macromolecule Metabolic Process
Negative Regulation Of MRNA Metabolic Process
Nucleoplasm
Nucleobase-containing Compound Metabolic Process
Post-transcriptional Regulation Of Gene Expression
Negative Regulation Of RNA Catabolic Process
Positive Regulation Of Gene Expression
Cytoplasmic Translation
Negative Regulation Of MRNA Catabolic Process
RNA Stabilization
Spliceosomal Complex Assembly
Regulation Of Translation
MRNA Stabilization
Regulation Of MRNA Processing
U4 SnRNP
U1 SnRNP
7-methylguanosine Cap Hypermethylation
U12-type Spliceosomal Complex
U2-type Prespliceosome Assembly
Cytosolic Ribosome
Regulation Of RNA Splicing
Negative Regulation Of Translation
U2 SnRNP
Positive Regulation Of Translation
Ribosome
Positive Regulation Of Cytoplasmic Translation
Regulation Of MRNA Stability
U2-type Spliceosomal Complex
Protein-RNA Complex Assembly
Methylosome
Regulation Of MRNA Splicing, Via Spliceosome
Regulation Of RNA Stability
Negative Regulation Of Gene Expression
Regulation Of Gene Expression
FNIP-folliculin RagC/D GAP
Lysosome Organization
Negative Regulation Of Protein Localization To Nucleus
Cellular Response To Amino Acid Starvation
Response To Amino Acid Starvation
Positive Regulation Of TORC1 Signaling
Protein Destabilization
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
TORC1 Signaling
Transport Of Viral Material Towards Nucleus
Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus
Positive Regulation Of TOR Signaling
TOR Signaling
Regulation Of TORC1 Signaling
Interleukin-7 Receptor Activity
Intracellular Transport Of Viral Protein In Host Cell
Regulation Of TOR Signaling
Regulation Of Protein Localization To Nucleus
Hemopoiesis
Vacuole Organization
Cellular Response To Starvation
Gtr1-Gtr2 GTPase Complex
Negative Regulation Of Lysosome Organization
Negative Regulation Of Cell Proliferation Involved In Kidney Development
Negative Regulation Of Brown Fat Cell Differentiation
Negative Regulation Of Protein Localization
Response To Starvation
Spindle
Interleukin-7-mediated Signaling Pathway
Positive Regulation Of T Cell Differentiation In Thymus
Intracellular Transport Of Virus
Cellular Response To Nutrient Levels
Regulation Of Pro-B Cell Differentiation
Host Cell
Secretory Vesicle
Negative Regulation Of T Cell Mediated Cytotoxicity
Cell Proliferation Involved In Kidney Development
Protein Localization To Nucleolus
Regulation Of Lymphoid Progenitor Cell Differentiation
Regulation Of Signal Transduction
Lysosomal Membrane
Regulation Of Protein Stability
Regulation Of Autophagy
Regulation Of Lysosome Organization
Negative Regulation Of Catabolic Process
Enzyme-substrate Adaptor Activity
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
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Tagcloud (Intersection)
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