IL7R and ILF3

Number of citations: 60 (PubMedID 23151878)
Data Source: BioGRID (unspecified method)

		IL7R	ILF3
Name		interleukin 7 receptor	interleukin enhancer binding factor 3
Structure
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Cytosol Plasma Membrane External Side Of Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane	Extracellular Region Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol Membrane Ribonucleoprotein Complex
	Molecular Function	Antigen Binding Cytokine Receptor Activity Interleukin-7 Receptor Activity Protein Binding	Virus Receptor Activity DNA Binding RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding Protein Binding MRNA 3'-UTR AU-rich Region Binding
	Biological Process	Regulation Of DNA Recombination Cell Morphogenesis B Cell Homeostasis T Cell Mediated Cytotoxicity Negative Regulation Of T Cell Mediated Cytotoxicity Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Cell Size Gene Expression Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Cellular Homeostasis Hemopoiesis T Cell Differentiation T Cell Differentiation In Thymus Positive Regulation Of T Cell Differentiation In Thymus Interleukin-7-mediated Signaling Pathway B Cell Proliferation T Cell Homeostasis Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Lymph Node Development Defense Response To Gram-positive Bacterium Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of Receptor Signaling Pathway Via STAT	Protein Phosphorylation Negative Regulation Of Translation Negative Regulation Of Viral Genome Replication Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Symbiont Entry Into Host Cell Defense Response To Virus Spliceosome-depend Formation Of Circular RNA
Pathways		Interleukin-7 signaling Interleukin-7 signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Regulation of CDH11 gene transcription Regulation of CDH11 gene transcription PKR-mediated signaling
Diseases		T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma	None
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011 29083406 ) Allergic rhinitis ( 31361310 30013184 ) Ankylosing spondylitis ( 23749187 ) Asthma ( 34103634 32296059 31619474 31361310 30929738 ) Asthma (adult onset) ( 30929738 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Atopic dermatitis ( 26482879 ) Basophil percentage of white cells ( 32888494 ) Blood protein levels ( 30072576 ) Eczema ( 31361310 ) Lymphocyte count ( 27863252 32888494 ) Lymphocyte percentage of white cells ( 27863252 32888494 ) Medication use (adrenergics, inhalants) ( 31015401 ) Monocyte percentage of white cells ( 32888494 ) Multiple sclerosis ( 31604244 21244703 19525953 21833088 24076602 ) Neutrophil percentage of white cells ( 27863252 32888494 ) Primary biliary cholangitis ( 26394269 21399635 30643196 23000144 28062665 ) Primary biliary cirrhosis ( 22961000 ) Systemic lupus erythematosus ( 33536424 ) Type 1 diabetes ( 25751624 17554260 ) Ulcerative colitis ( 21297633 ) White blood cell count ( 32888494 )	Bipolar disorder ( 31043756 ) Chronotype ( 30696823 ) Height ( 25282103 25429064 ) Obesity-related traits ( 23251661 ) Psoriasis ( 23143594 25574825 25903422 ) Psoriasis vulgaris ( 26626624 ) Rheumatoid arthritis ( 30423114 ) Systemic lupus erythematosus ( 28714469 )
Interacting Genes		110 interacting genes: AGTRAP ALYREF APOL3 CIRBP CPSF1 CRLF2 DDX21 DDX39B DDX3X DDX5 DHX36 DHX9 EIF2AK2 ELAVL1 EMG1 FAU FUS FYN G3BP1 H1-10 H1-2 H1-4 H2BC21 HNRNPA0 HNRNPA3 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPH3 HNRNPL HNRNPR HNRNPU HNRNPUL1 HNRNPUL2 IL2RG IL7 ILF2 ILF3 JAK1 JAK3 KIT LYN MALL MAP4 MS4A1 NCL NONO PABPC1 PABPC4 PABPN1 PIK3R1 PTBP1 PTK2B PTMA PURA PURB QKI RACK1 RAD21 RBM3 RBMX RPL15 RPL18 RPL22 RPL29 RPL30 RPL31 RPL6 RPL7 RPL8 RPS20 RPS3 RPSA RRAGA RSL1D1 SAFB SDC4 SF1 SF3A1 SF3B1 SNRNP70 SNRPA SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SRP14 SRP9 SRSF3 SRSF9 SSB STAT3 STAT5A STAT5B SYNCRIP TMEM120B TOE1 TOP1 TSLP U2AF1 U2AF2 YBX1 YBX3 YWHAE YWHAG ZNF787	44 interacting genes: CEBPA DHX9 DUX4 EIF2AK2 EP300 ERBB2 ERG ESR1 FUS GDF9 HNRNPH2 IL7R IRF3 IRF9 KRTAP4-12 LINC00624 LNX1 MAGEA11 MAPK1 MDFI NDRG1 OGT PLSCR1 PRMT1 PRMT5 PSMA3 PTEN RBM5 RBPMS SF1 SF3B4 SMN1 SPOP TRIM55 TRIM63 TRIP6 UBC USP7 VPS37C XAB2 XPO5 YWHAH ZNF346 ZNF830
Entrez ID		3575	3609
HPRD ID		00893	04420
Ensembl ID		ENSG00000168685	ENSG00000129351
Uniprot IDs		P16871	Q12906
PDB IDs		3DI2 3DI3 3UP1 5J11 6P50 6P67 7OPB	2L33 3P1X 7RJM 7RJQ
GO Terms Enriched among Interactors		RNA Binding Ribonucleoprotein Complex Nucleic Acid Binding RNA Processing MRNA Processing RNA Splicing Spliceosomal Complex MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process MRNA Binding Nucleus Catalytic Step 2 Spliceosome Nucleic Acid Metabolic Process Regulation Of MRNA Metabolic Process Macromolecule Metabolic Process Negative Regulation Of MRNA Metabolic Process Nucleoplasm Nucleobase-containing Compound Metabolic Process Post-transcriptional Regulation Of Gene Expression Negative Regulation Of RNA Catabolic Process Positive Regulation Of Gene Expression Cytoplasmic Translation Negative Regulation Of MRNA Catabolic Process RNA Stabilization Spliceosomal Complex Assembly Regulation Of Translation MRNA Stabilization Regulation Of MRNA Processing U4 SnRNP U1 SnRNP 7-methylguanosine Cap Hypermethylation U12-type Spliceosomal Complex U2-type Prespliceosome Assembly Cytosolic Ribosome Regulation Of RNA Splicing Negative Regulation Of Translation U2 SnRNP Positive Regulation Of Translation Ribosome Positive Regulation Of Cytoplasmic Translation Regulation Of MRNA Stability U2-type Spliceosomal Complex Protein-RNA Complex Assembly Methylosome Regulation Of MRNA Splicing, Via Spliceosome Regulation Of RNA Stability Negative Regulation Of Gene Expression Regulation Of Gene Expression	Nucleoplasm Nucleus Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding RNA Splicing Rhythmic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Protein-RNA Complex Assembly Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression Cytosol Regulation Of Macromolecule Biosynthetic Process Intracellular Signal Transduction Cytoplasm Positive Regulation Of RNA Metabolic Process RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Spliceosomal Complex Assembly Protein Modification Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nucleic Acid Binding Regulation Of Macromolecule Metabolic Process RNA Splicing, Via Transesterification Reactions DNA-templated Transcription Termination RNA Binding Nucleic Acid Metabolic Process TORC1 Signaling Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Response To Stress Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Regulation Of Cell Population Proliferation Macromolecule Biosynthetic Process Cellular Component Assembly RNA Processing Cellular Response To Nutrient Levels Protein-containing Complex Assembly RISC Complex Binding Histone H4R3 Methyltransferase Activity Peptidyl-arginine Methylation TOR Signaling Chromatin DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process