IL7R and DDX5

Number of citations of the paper that reports this interaction (PubMedID 23151878)
60

Data Source:
BioGRID (unspecified method)

		IL7R	DDX5
Description		interleukin 7 receptor	DEAD-box helicase 5
Image
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Cytosol Plasma Membrane External Side Of Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane	Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Cytoplasm Cytosol Membrane Nuclear Speck Extracellular Exosome Catalytic Step 2 Spliceosome Ribonucleoprotein Complex
	Molecular Function	Antigen Binding Cytokine Receptor Activity Interleukin-7 Receptor Activity Protein Binding	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity MRNA Binding MRNA 3'-UTR Binding Helicase Activity Protein Binding Calmodulin Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Enzyme Binding MH2 Domain Binding Pre-mRNA Binding Ribonucleoprotein Complex Binding SMAD Binding Calcium-dependent Protein Binding Nuclear Androgen Receptor Binding R-SMAD Binding Primary MiRNA Binding Promoter-specific Chromatin Binding
	Biological Process	Regulation Of DNA Recombination Cell Morphogenesis B Cell Homeostasis T Cell Mediated Cytotoxicity Negative Regulation Of T Cell Mediated Cytotoxicity Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Cell Size Gene Expression Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Cellular Homeostasis Hemopoiesis T Cell Differentiation T Cell Differentiation In Thymus Positive Regulation Of T Cell Differentiation In Thymus Interleukin-7-mediated Signaling Pathway B Cell Proliferation T Cell Homeostasis Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Lymph Node Development Defense Response To Gram-positive Bacterium Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of Receptor Signaling Pathway Via STAT	Negative Regulation Of Transcription By RNA Polymerase II Alternative MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Nuclear-transcribed MRNA Catabolic Process Epithelial To Mesenchymal Transition Regulation Of Transcription By RNA Polymerase II MRNA Processing RNA Splicing MRNA Transcription BMP Signaling Pathway Estrogen Receptor Signaling Pathway Androgen Receptor Signaling Pathway Primary MiRNA Processing Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Viral Genome Replication Myoblast Differentiation Regulation Of Osteoblast Differentiation Rhythmic Process Regulation Of Androgen Receptor Signaling Pathway MiRNA Transcription Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of MiRNA Transcription Regulation Of Skeletal Muscle Cell Differentiation
Pathways		Interleukin-7 signaling Interleukin-7 signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	SUMOylation of transcription cofactors mRNA Splicing - Major Pathway Estrogen-dependent gene expression Replication of the SARS-CoV-1 genome Replication of the SARS-CoV-2 genome
Drugs			Artenimol
Diseases		T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma	Prostate cancer
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011 29083406) Allergic rhinitis ( 31361310 30013184) Ankylosing spondylitis ( 23749187) Asthma ( 34103634 32296059 31619474 31361310 30929738) Asthma (adult onset) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879) Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576) Eczema ( 31361310) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Medication use (adrenergics, inhalants) ( 31015401) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244 21244703 19525953 21833088 24076602) Neutrophil percentage of white cells ( 27863252 32888494) Primary biliary cholangitis ( 26394269 21399635 30643196 23000144 28062665) Primary biliary cirrhosis ( 22961000) Systemic lupus erythematosus ( 33536424) Type 1 diabetes ( 25751624 17554260) Ulcerative colitis ( 21297633) White blood cell count ( 32888494)	Lung function (FVC) ( 30804560) Refractive error ( 32231278)
Interacting Genes		110 interacting genes: AGTRAP ALYREF APOL3 CIRBP CPSF1 CRLF2 DDX21 DDX39B DDX3X DDX5 DHX36 DHX9 EIF2AK2 ELAVL1 EMG1 FAU FUS FYN G3BP1 H1-10 H1-2 H1-4 H2BC21 HNRNPA0 HNRNPA3 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPH3 HNRNPL HNRNPR HNRNPU HNRNPUL1 HNRNPUL2 IL2RG IL7 ILF2 ILF3 JAK1 JAK3 KIT LYN MALL MAP4 MS4A1 NCL NONO PABPC1 PABPC4 PABPN1 PIK3R1 PTBP1 PTK2B PTMA PURA PURB QKI RACK1 RAD21 RBM3 RBMX RPL15 RPL18 RPL22 RPL29 RPL30 RPL31 RPL6 RPL7 RPL8 RPS20 RPS3 RPSA RRAGA RSL1D1 SAFB SDC4 SF1 SF3A1 SF3B1 SNRNP70 SNRPA SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SRP14 SRP9 SRSF3 SRSF9 SSB STAT3 STAT5A STAT5B SYNCRIP TMEM120B TOE1 TOP1 TSLP U2AF1 U2AF2 YBX1 YBX3 YWHAE YWHAG ZNF787	39 interacting genes: AKAP8 CALM1 CEBPA CREBBP DDX17 DUX4 ESR1 FBL FRS3 H19 HNRNPA0 HNRNPH2 HNRNPH3 HNRNPK IL7R KHDRBS1 LINC00624 MAPKAPK2 NCOA1 NCOA2 NCOA3 NDRG1 OGT PIAS1 PIK3CA PIN1 PRKCA PSMA3 RBFOX2 RBM10 RBM4 SLC26A4-AS1 SMAD3 SUMO2 TNNT1 TP53 UBE2I USP7 WBP11
Entrez ID		3575	1655
HPRD ID		00893	01615
Ensembl ID		ENSG00000168685	ENSG00000108654
Uniprot IDs		P16871	J3KTA4 P17844
PDB IDs		3DI2 3DI3 3UP1 5J11 6P50 6P67 7OPB	3FE2 4A4D
Enriched GO Terms of Interacting Partners?		RNA Binding Ribonucleoprotein Complex Nucleic Acid Binding RNA Processing MRNA Processing RNA Splicing Spliceosomal Complex MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process MRNA Binding Nucleus Catalytic Step 2 Spliceosome Nucleic Acid Metabolic Process Regulation Of MRNA Metabolic Process Macromolecule Metabolic Process Negative Regulation Of MRNA Metabolic Process Nucleoplasm Nucleobase-containing Compound Metabolic Process Post-transcriptional Regulation Of Gene Expression Negative Regulation Of RNA Catabolic Process Positive Regulation Of Gene Expression Cytoplasmic Translation Negative Regulation Of MRNA Catabolic Process RNA Stabilization Spliceosomal Complex Assembly Regulation Of Translation MRNA Stabilization Regulation Of MRNA Processing U4 SnRNP U1 SnRNP 7-methylguanosine Cap Hypermethylation U12-type Spliceosomal Complex U2-type Prespliceosome Assembly Cytosolic Ribosome Regulation Of RNA Splicing Negative Regulation Of Translation U2 SnRNP Positive Regulation Of Translation Ribosome Positive Regulation Of Cytoplasmic Translation Regulation Of MRNA Stability U2-type Spliceosomal Complex Protein-RNA Complex Assembly Methylosome Regulation Of MRNA Splicing, Via Spliceosome Regulation Of RNA Stability Negative Regulation Of Gene Expression Regulation Of Gene Expression	Nucleoplasm Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Nucleus Negative Regulation Of Macromolecule Metabolic Process MRNA Metabolic Process Regulation Of RNA Splicing Protein-containing Complex Negative Regulation Of Metabolic Process Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Macromolecule Metabolic Process Regulation Of MRNA Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Rhythmic Process Nuclear Receptor-mediated Signaling Pathway Nucleic Acid Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Catabolic Process Estrogen Receptor Signaling Pathway Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Metabolic Process RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Presynaptic Cytosol Signal Transduction MRNA Processing Postsynaptic Cytosol Regulation Of MRNA Processing Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Hormone Response To Lipid Transcription Regulator Complex Chromatin Remodeling Chromatin Organization Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Processing Regulation Of Transcription By RNA Polymerase II Nuclear Receptor Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process
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