IL7R and CRLF2

Number of citations of the paper that reports this interaction (PubMedID 11418668)
0

Data Source:
HPRD (in vivo)

		IL7R	CRLF2
Description		interleukin 7 receptor	cytokine receptor like factor 2
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GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Cytosol Plasma Membrane External Side Of Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex
	Molecular Function	Antigen Binding Cytokine Receptor Activity Interleukin-7 Receptor Activity Protein Binding	Cytokine Receptor Activity Coreceptor Activity Cytokine Binding
	Biological Process	Regulation Of DNA Recombination Cell Morphogenesis B Cell Homeostasis T Cell Mediated Cytotoxicity Negative Regulation Of T Cell Mediated Cytotoxicity Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Cell Size Gene Expression Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Cellular Homeostasis Hemopoiesis T Cell Differentiation T Cell Differentiation In Thymus Positive Regulation Of T Cell Differentiation In Thymus Interleukin-7-mediated Signaling Pathway B Cell Proliferation T Cell Homeostasis Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Lymph Node Development Defense Response To Gram-positive Bacterium Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of Receptor Signaling Pathway Via STAT	Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-5 Production Positive Regulation Of Mast Cell Activation Positive Regulation Of Receptor Signaling Pathway Via STAT
Pathways		Interleukin-7 signaling Interleukin-7 signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Interleukin-7 signaling Interleukin-7 signaling
Drugs
Diseases		T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011 29083406) Allergic rhinitis ( 31361310 30013184) Ankylosing spondylitis ( 23749187) Asthma ( 34103634 32296059 31619474 31361310 30929738) Asthma (adult onset) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879) Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576) Eczema ( 31361310) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Medication use (adrenergics, inhalants) ( 31015401) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244 21244703 19525953 21833088 24076602) Neutrophil percentage of white cells ( 27863252 32888494) Primary biliary cholangitis ( 26394269 21399635 30643196 23000144 28062665) Primary biliary cirrhosis ( 22961000) Systemic lupus erythematosus ( 33536424) Type 1 diabetes ( 25751624 17554260) Ulcerative colitis ( 21297633) White blood cell count ( 32888494)
Interacting Genes		110 interacting genes: AGTRAP ALYREF APOL3 CIRBP CPSF1 CRLF2 DDX21 DDX39B DDX3X DDX5 DHX36 DHX9 EIF2AK2 ELAVL1 EMG1 FAU FUS FYN G3BP1 H1-10 H1-2 H1-4 H2BC21 HNRNPA0 HNRNPA3 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPH3 HNRNPL HNRNPR HNRNPU HNRNPUL1 HNRNPUL2 IL2RG IL7 ILF2 ILF3 JAK1 JAK3 KIT LYN MALL MAP4 MS4A1 NCL NONO PABPC1 PABPC4 PABPN1 PIK3R1 PTBP1 PTK2B PTMA PURA PURB QKI RACK1 RAD21 RBM3 RBMX RPL15 RPL18 RPL22 RPL29 RPL30 RPL31 RPL6 RPL7 RPL8 RPS20 RPS3 RPSA RRAGA RSL1D1 SAFB SDC4 SF1 SF3A1 SF3B1 SNRNP70 SNRPA SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SRP14 SRP9 SRSF3 SRSF9 SSB STAT3 STAT5A STAT5B SYNCRIP TMEM120B TOE1 TOP1 TSLP U2AF1 U2AF2 YBX1 YBX3 YWHAE YWHAG ZNF787	3 interacting genes: IL7R JAK2 TSLP
Entrez ID		3575	64109
HPRD ID		00893	02288
Ensembl ID		ENSG00000168685	ENSG00000205755
Uniprot IDs		P16871	Q9HC73
PDB IDs		3DI2 3DI3 3UP1 5J11 6P50 6P67 7OPB	5J11 5J12
Enriched GO Terms of Interacting Partners?		RNA Binding Ribonucleoprotein Complex Nucleic Acid Binding RNA Processing MRNA Processing RNA Splicing Spliceosomal Complex MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process MRNA Binding Nucleus Catalytic Step 2 Spliceosome Nucleic Acid Metabolic Process Regulation Of MRNA Metabolic Process Macromolecule Metabolic Process Negative Regulation Of MRNA Metabolic Process Nucleoplasm Nucleobase-containing Compound Metabolic Process Post-transcriptional Regulation Of Gene Expression Negative Regulation Of RNA Catabolic Process Positive Regulation Of Gene Expression Cytoplasmic Translation Negative Regulation Of MRNA Catabolic Process RNA Stabilization Spliceosomal Complex Assembly Regulation Of Translation MRNA Stabilization Regulation Of MRNA Processing U4 SnRNP U1 SnRNP 7-methylguanosine Cap Hypermethylation U12-type Spliceosomal Complex U2-type Prespliceosome Assembly Cytosolic Ribosome Regulation Of RNA Splicing Negative Regulation Of Translation U2 SnRNP Positive Regulation Of Translation Ribosome Positive Regulation Of Cytoplasmic Translation Regulation Of MRNA Stability U2-type Spliceosomal Complex Protein-RNA Complex Assembly Methylosome Regulation Of MRNA Splicing, Via Spliceosome Regulation Of RNA Stability Negative Regulation Of Gene Expression Regulation Of Gene Expression	Positive Regulation Of Receptor Signaling Pathway Via STAT Interleukin-7-mediated Signaling Pathway Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Cytokine-mediated Signaling Pathway Positive Regulation Of Cell Activation Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Activation Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of Cell Population Proliferation Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Histone H3Y41 Kinase Activity Nuclear Receptor-mediated Mineralocorticoid Signaling Pathway Symbiont-induced Defense-related Programmed Cell Death Interleukin-35-mediated Signaling Pathway Positive Regulation Of Chemokine (C-C Motif) Ligand 1 Production Positive Regulation Of Immune System Process T Cell Differentiation Immune Response Response To Other Organism Positive Regulation Of Gene Expression Hemopoiesis Interleukin-7 Receptor Activity Regulation Of Postsynapse To Nucleus Signaling Pathway Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Interleukin-7 Receptor Binding Defense Response Response To External Biotic Stimulus Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Adaptive Immune Response Interleukin-12 Receptor Complex Positive Regulation Of Skeletal Muscle Cell Proliferation Positive Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Granulocyte Colony-stimulating Factor Production Positive Regulation Of Macrophage Colony-stimulating Factor Production Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of T Cell Activation Lymphocyte Differentiation Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Response To Interleukin-12 Interleukin-23 Receptor Complex Granulocyte Macrophage Colony-stimulating Factor Receptor Complex Activation Of Janus Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Leukocyte Cell-cell Adhesion Adaptive Immune Response Positive Regulation Of Multicellular Organismal Process Defense Response To Bacterium
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