IL7R and DHX36

Number of citations of the paper that reports this interaction (PMID 23151878)
3

Data Source:
BioGRID (unspecified method)

		IL7R	DHX36
Gene Name		interleukin 7 receptor	DEAH (Asp-Glu-Ala-His) box polypeptide 36
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane	Chromosome, Telomeric Region Nucleus Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	Antigen Binding Interleukin-7 Receptor Activity Protein Binding	Core Promoter Binding G-quadruplex RNA Binding Double-stranded RNA Binding ATP-dependent RNA Helicase Activity Protein Binding ATP Binding DNA-dependent ATPase Activity Histone Deacetylase Binding Transcription Regulatory Region DNA Binding Poly(A) RNA Binding G-quadruplex DNA Binding
	Biological Process	Regulation Of DNA Recombination Cell Morphogenesis Negative Regulation Of T Cell Mediated Cytotoxicity Immunoglobulin Production Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Cell Size Positive Regulation Of Gene Expression Cell Growth T Cell Differentiation Positive Regulation Of T Cell Differentiation In Thymus Interleukin-7-mediated Signaling Pathway B Cell Proliferation Lymph Node Development Homeostasis Of Number Of Cells	Ossification Transcription, DNA-templated RNA Processing Response To Virus RNA Secondary Structure Unwinding Positive Regulation Of Telomere Maintenance Positive Regulation Of Type I Interferon Production Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		Signaling by Interleukins Interleukin-7 signaling Cytokine Signaling in Immune system	DEx/H-box helicases activate type I IFN and inflammatory cytokines production RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Toll Like Receptor 7/8 (TLR7/8) Cascade Cytosolic sensors of pathogen-associated DNA MyD88 dependent cascade initiated on endosome TRAF6 mediated IRF7 activation Toll Like Receptor 9 (TLR9) Cascade TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling Innate Immune System
Drugs
Diseases
GWAS		Multiple sclerosis ( 21244703 19525953 21833088) Primary biliary cirrhosis ( 23000144 21399635) Type 1 diabetes ( 17554260) Ulcerative colitis ( 21297633)
Protein-Protein Interactions		104 interactors: ALYREF CIRBP CPSF1 CRLF2 DDX21 DDX39B DDX3X DDX5 DHX36 DHX9 EIF2AK2 ELAVL1 EMG1 FAU FUS FYN G3BP1 GNB2L1 H1FX HIST1H1C HIST1H1E HIST2H2BE HNRNPA0 HNRNPA3 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPH3 HNRNPL HNRNPR HNRNPU HNRNPUL1 HNRNPUL2 IL2RG IL7 ILF2 ILF3 JAK1 JAK3 KIT LYN MAP4 NCL NONO PABPC1 PABPC4 PABPN1 PIK3R1 PTBP1 PTK2B PTMA PURA PURB QKI RAD21 RBM3 RBMX RPL15 RPL18 RPL22 RPL29 RPL30 RPL31 RPL6 RPL7 RPL8 RPS20 RPS3 RPSA RRAGA RSL1D1 SAFB SF1 SF3A1 SF3B1 SNRNP70 SNRPA SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SRP14 SRP9 SRSF3 SRSF9 SSB STAT3 STAT5A STAT5B SYNCRIP TOE1 TOP1 TSLP U2AF1 U2AF2 YBX1 YBX3 YWHAE YWHAG ZNF787	3 interactors: IL7R TLR1 ZFP36
Entrez ID		3575	170506
HPRD ID		00893	09918
Ensembl ID		ENSG00000168685	ENSG00000174953
Uniprot IDs		D6RGV2 D9N160 P16871	Q9H2U1
PDB IDs		3DI2 3DI3 3UP1
Enriched GO Terms of Interacting Partners?		MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing RNA Splicing MRNA Processing RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Viral Process RNA Biosynthetic Process SRP-dependent Cotranslational Protein Targeting To Membrane Termination Of RNA Polymerase II Transcription Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Cellular Macromolecule Biosynthetic Process Regulation Of MRNA Stability Regulation Of RNA Stability Macromolecule Biosynthetic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Protein Localization To Endoplasmic Reticulum Viral Life Cycle Cytoplasmic Transport Posttranscriptional Regulation Of Gene Expression MRNA Stabilization RNA 3'-end Processing MRNA 3'-end Processing RNA Catabolic Process Viral Transcription Cellular Metabolic Process Protein Targeting To Membrane DNA-templated Transcription, Termination Protein Targeting Nuclear-transcribed MRNA Catabolic Process Establishment Of Protein Localization To Organelle MRNA Catabolic Process Ribonucleoprotein Complex Assembly Regulation Of Translation Ribonucleoprotein Complex Biogenesis Biosynthetic Process Protein Localization To Organelle Translational Termination Establishment Of Protein Localization To Membrane Intracellular Transport Translational Elongation	Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 1 Signaling Pathway Regulation Of Immune System Process Interleukin-7-mediated Signaling Pathway Detection Of Triacyl Bacterial Lipopeptide Cellular Response To Triacyl Bacterial Lipopeptide Negative Regulation Of T Cell Mediated Cytotoxicity Negative Regulation Of Immune System Process Detection Of Bacterial Lipoprotein Negative Regulation Of Translation Involved In Gene Silencing By MiRNA 3'-UTR-mediated MRNA Stabilization Leukocyte Activation Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Interleukin-6 Biosynthetic Process Cellular Response To Bacterial Lipopeptide RNA Destabilization Regulation Of Cytokine Production Detection Of Molecule Of Bacterial Origin Negative Regulation Of T Cell Mediated Immunity Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Lymph Node Development Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of T Cell Differentiation In Thymus Regulation Of Tumor Necrosis Factor Biosynthetic Process Regulation Of MRNA 3'-end Processing Regulation Of Interleukin-6 Biosynthetic Process Cell Activation Detection Of Bacterium Positive Regulation Of MRNA Catabolic Process Positive Regulation Of Metabolic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Stabilization Detection Of Biotic Stimulus Macrophage Activation Regulation Of Immune Response Regulation Of T Cell Differentiation In Thymus Positive Regulation Of Immune System Process Gene Silencing By MiRNA Negative Regulation Of Adaptive Immune Response Posttranscriptional Gene Silencing B Cell Proliferation Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of MRNA Stability Positive Regulation Of Tumor Necrosis Factor Production Regulation Of RNA Stability Immunoglobulin Production Gene Silencing By RNA Positive Regulation Of Interleukin-6 Production Positive Regulation Of Cytokine Biosynthetic Process
Tagcloud ?		aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1	another antiviral atpase avsg box defect defense dexd dsrna facilitate facilitates forming granule helicase ifn inducible initiate interferon ko mef pkr recognition rig rlr rna sensor stranded summary viruses
Tagcloud (Difference) ?		aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1	another antiviral atpase avsg box defect defense dexd dsrna facilitate facilitates forming granule helicase ifn inducible initiate interferon ko mef pkr recognition rig rlr rna sensor stranded summary viruses
Tagcloud (Intersection) ?