PELI1 and VAC14

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		PELI1	VAC14
Description		pellino E3 ubiquitin protein ligase 1	VAC14 component of PIKFYVE complex
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GO Annotations	Cellular Component	Nucleus Chromosome Cytoplasm Cytosol Site Of Double-strand Break	Golgi Membrane Endosome Endoplasmic Reticulum Cytosol Endosome Membrane Membrane Early Endosome Membrane Late Endosome Membrane PAS Complex Presynaptic Endosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity	Protein Binding Signaling Receptor Activity Identical Protein Binding
	Biological Process	Protein Polyubiquitination Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Cytokine Production DNA Repair DNA Damage Response Regulation Of Toll Signaling Pathway Protein Ubiquitination Positive Regulation Of B Cell Proliferation Positive Regulation Of Protein Ubiquitination Response To Lipopolysaccharide Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway TORC1 Signaling T Cell Proliferation T Cell Activation Negative Regulation Of T Cell Proliferation Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To DsRNA Negative Regulation Of T Cell Activation Positive Regulation Of B Cell Activation Regulation Of Necroptotic Process Negative Regulation Of Necroptotic Process Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of Double-strand Break Repair Via Homologous Recombination	Phosphatidylinositol Biosynthetic Process Signal Transduction Regulation Of Postsynaptic Neurotransmitter Receptor Internalization
Pathways		Regulation of necroptotic cell death Interleukin-1 signaling IRAK1 recruits IKK complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Synthesis of PIPs at the late endosome membrane
Drugs
Diseases
GWAS		Allergic dermatitis (nickel) ( 23921680) HOMA-B (corrected for HOMA-IR) ( 30369944) Kawasaki disease ( 21221998)	Diffuse cutaneous systemic sclerosis ( 29293537) Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer ( 27143689) High density lipoprotein cholesterol levels ( 28548082) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Malaria ( 31844061) Pulse pressure ( 28135244)
Interacting Genes		33 interacting genes: BCL6 BIRC3 BUB1B CLEC17A CNTROB EGFR GOSR2 IKBKB INPP5J IRAK1 IRAK2 IRAK4 IRS1 LCN2 LMNA MDM4 RIMS4 RIPK3 SQSTM1 SRPK1 SRPK2 TP53 TP63 TRIP13 UBC UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2N UBE2V1 VAC14 ZAP70	107 interacting genes: ABHD11 ACSS1 ACTMAP AMT APP ARID5A ASB13 ATM BCL2L1 BHLHE40 BKGD C4orf33 CASP1 CATSPERT CD209 CDRT4 CNTN2 COL8A1 CRK CRYBA1 CRYBA2 DDAH2 DNAAF19 EEF1AKMT3 EHHADH EIF2S1 EIF6 FAM50B FNDC3B GABPB2 GALT GINS3 GLIS2 GNB1 GTF3C2 HDHD3 HNF1B HNRNPLL INTS11 JMJD7 KHDC1 KRABD5 KRT82 KRTAP15-1 KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP6-1 KRTAP6-2 KYAT1 LASP1 LINC00518 LPAL2 MBLAC1 MEOX2 METTL15 MGAT5B MPPED2 MTMR9 MVP MYOZ1 NDUFAB1 NGB NOS1 NTAQ1 OIT3 OTOS PBLD PCMTD2 PDE4DIP PELI1 PHF1 PHYKPL PIKFYVE PPP2CA PPP6C PRADC1 PRR13 PRR20A PRR20B PRR20C PRR20D PRR20E RBFOX2 RHBDL1 RHOXF2 RIPPLY1 RNASEH2C RSKR SIGLEC5 SMUG1 SNF8 SPMIP9 SPRYD7 SRPK2 TCEANC TP53BP1 TRIM55 TRIM63 UFSP1 VENTX VHLL WDR83 WRAP53 ZBTB49 ZCWPW1 ZNF34
Entrez ID		57162	55697
HPRD ID		17834	07660
Ensembl ID		ENSG00000197329	ENSG00000103043
Uniprot IDs		Q53T26 Q96FA3	Q08AM6
PDB IDs		9IF9	7K1Y
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction ATP Binding Non-canonical NF-kappaB Signal Transduction Ubiquitin Conjugating Enzyme Activity Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Modification Process Regulation Of Intracellular Signal Transduction Nucleotide Binding Protein Kinase Activity MyD88-dependent Toll-like Receptor Signaling Pathway Cytosol Intracellular Signaling Cassette Positive Regulation Of Intracellular Signal Transduction Transferase Activity Interleukin-1-mediated Signaling Pathway Toll Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling Cellular Response To Stress Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Modification By Small Protein Conjugation Signal Transduction Positive Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Protein Polyubiquitination Immune Response-regulating Cell Surface Receptor Signaling Pathway Endosome Membrane Protein-containing Complex Toll-like Receptor 4 Signaling Pathway Protein Ubiquitination Cell Surface Toll-like Receptor Signaling Pathway Kinase Activity Negative Regulation Of Signaling Negative Regulation Of Cell Communication Toll-like Receptor Signaling Pathway Post-translational Protein Modification Response To Stress Cell Surface Pattern Recognition Receptor Signaling Pathway Immune System Process Protein Serine Kinase Activity Immune Response-activating Signaling Pathway Canonical NF-kappaB Signal Transduction Positive Regulation Of Protein Polyubiquitination Cellular Response To Hypoxia Nucleus	Protein Binding Intermediate Filament
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