PELI1 and RIMS4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PELI1	RIMS4
Description		pellino E3 ubiquitin protein ligase 1	regulating synaptic membrane exocytosis 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Chromosome Cytoplasm Cytosol Site Of Double-strand Break	Membrane Synapse Presynaptic Active Zone Synaptic Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity	Protein Binding Small GTPase Binding Transmembrane Transporter Binding
	Biological Process	Protein Polyubiquitination Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Cytokine Production DNA Repair DNA Damage Response Regulation Of Toll Signaling Pathway Protein Ubiquitination Positive Regulation Of B Cell Proliferation Positive Regulation Of Protein Ubiquitination Response To Lipopolysaccharide Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway TORC1 Signaling T Cell Proliferation T Cell Activation Negative Regulation Of T Cell Proliferation Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To DsRNA Negative Regulation Of T Cell Activation Positive Regulation Of B Cell Activation Regulation Of Necroptotic Process Negative Regulation Of Necroptotic Process Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of Double-strand Break Repair Via Homologous Recombination	Neurotransmitter Transport Exocytosis Regulation Of Membrane Potential Regulation Of Synaptic Vesicle Exocytosis
Pathways		Regulation of necroptotic cell death Interleukin-1 signaling IRAK1 recruits IKK complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Drugs
Diseases
GWAS		Allergic dermatitis (nickel) ( 23921680) HOMA-B (corrected for HOMA-IR) ( 30369944) Kawasaki disease ( 21221998)	Breakfast cereal skipping frequency ( 31190057) Breakfast skipping ( 31190057) Meat-related diet ( 32066663) Obesity-related traits ( 23251661)
Interacting Genes		33 interacting genes: BCL6 BIRC3 BUB1B CLEC17A CNTROB EGFR GOSR2 IKBKB INPP5J IRAK1 IRAK2 IRAK4 IRS1 LCN2 LMNA MDM4 RIMS4 RIPK3 SQSTM1 SRPK1 SRPK2 TP53 TP63 TRIP13 UBC UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2N UBE2V1 VAC14 ZAP70	4 interacting genes: APP PELI1 SPP1 SRPK1
Entrez ID		57162	140730
HPRD ID		17834	17977
Ensembl ID		ENSG00000197329	ENSG00000101098
Uniprot IDs		Q53T26 Q96FA3	Q9H426
PDB IDs		9IF9
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction ATP Binding Non-canonical NF-kappaB Signal Transduction Ubiquitin Conjugating Enzyme Activity Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Modification Process Regulation Of Intracellular Signal Transduction Nucleotide Binding Protein Kinase Activity MyD88-dependent Toll-like Receptor Signaling Pathway Cytosol Intracellular Signaling Cassette Positive Regulation Of Intracellular Signal Transduction Transferase Activity Interleukin-1-mediated Signaling Pathway Toll Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling Cellular Response To Stress Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Modification By Small Protein Conjugation Signal Transduction Positive Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Protein Polyubiquitination Immune Response-regulating Cell Surface Receptor Signaling Pathway Endosome Membrane Protein-containing Complex Toll-like Receptor 4 Signaling Pathway Protein Ubiquitination Cell Surface Toll-like Receptor Signaling Pathway Kinase Activity Negative Regulation Of Signaling Negative Regulation Of Cell Communication Toll-like Receptor Signaling Pathway Post-translational Protein Modification Response To Stress Cell Surface Pattern Recognition Receptor Signaling Pathway Immune System Process Protein Serine Kinase Activity Immune Response-activating Signaling Pathway Canonical NF-kappaB Signal Transduction Positive Regulation Of Protein Polyubiquitination Cellular Response To Hypoxia Nucleus	Regulation Of Toll Signaling Pathway Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Cellular Response To Stress Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Integrin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Estradiol Secretion Regulation Of Estradiol Secretion Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Androgen Catabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Axon Choice Point Recognition Cellular Response To Testosterone Stimulus Response To External Biotic Stimulus Endoplasmic Reticulum Lumen Heparan Sulfate Binding Signaling Receptor Activator Activity Response To 2,3,7,8-tetrachlorodibenzodioxine Peptidase Activator Activity Regulation Of Developmental Growth Cellular Response To Manganese Ion Response To Macrophage Colony-stimulating Factor
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