PELI1 and BCL6

Number of citations of the paper that reports this interaction (PMID 25295537)
0

Data Source:
BioGRID (enzymatic study)

		PELI1	BCL6
Gene Name		pellino E3 ubiquitin protein ligase 1	B-cell CLL/lymphoma 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol	Nucleus Replication Fork
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Chromatin DNA Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Cytokine Production Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll Signaling Pathway Positive Regulation Of B Cell Proliferation Positive Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Lipopolysaccharide Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Negative Regulation Of T Cell Proliferation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To DsRNA Innate Immune Response Protein K48-linked Ubiquitination	Protein Import Into Nucleus, Translocation Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Morphogenesis Negative Regulation Of Cell-matrix Adhesion Germinal Center Formation Regulation Of Germinal Center Formation Negative Regulation Of B Cell Apoptotic Process Transcription, DNA-templated Inflammatory Response Cellular Response To DNA Damage Stimulus Rho Protein Signal Transduction Spermatogenesis Negative Regulation Of Cell Proliferation Actin Cytoskeleton Organization B Cell Differentiation Negative Regulation Of Cell Growth Positive Regulation Of B Cell Proliferation Positive Regulation Of Histone Deacetylation Regulation Of Rho GTPase Activity Negative Regulation Of Mast Cell Cytokine Production Negative Regulation Of Rho Protein Signal Transduction Type 2 Immune Response Positive Regulation Of Apoptotic Process Regulation Of Memory T Cell Differentiation Negative Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Neuron Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Isotype Switching To IgE Isotypes Erythrocyte Development Regulation Of Inflammatory Response Regulation Of Immune Response Positive Regulation Of Cellular Component Movement Negative Regulation Of Cellular Senescence
Pathways		Toll Like Receptor 7/8 (TLR7/8) Cascade Cytokine Signaling in Immune system Toll Like Receptor TLR6:TLR2 Cascade IRAK1 recruits IKK complex Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Signaling by Interleukins Toll-Like Receptors Cascades MyD88 cascade initiated on plasma membrane Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 5 (TLR5) Cascade Toll Like Receptor 4 (TLR4) Cascade MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Interleukin-1 signaling Toll Like Receptor 9 (TLR9) Cascade IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation IRAK1 recruits IKK complex Innate Immune System
Drugs
Diseases
GWAS		Kawasaki disease ( 21221998)	B cell non-Hodgkin lymphoma ( 23749188) PR interval ( 23534349) Pulmonary function (interaction) ( 23284291) Renal function-related traits (BUN) ( 22797727)
Protein-Protein Interactions		17 interactors: BCL6 IKBKB IRAK1 IRAK2 IRAK4 RIPK1 SRPK1 SRPK2 TBK1 TRIP13 UBC UBE2D1 UBE2D2 UBE2I UBE2N UBE2V1 VAC14	44 interactors: AES BCL11A BCL6B BCOR BLZF1 CDK19 CDK8 CHD3 CREBBP CUTC EP300 FBXO11 HDAC4 HDAC5 HDAC7 HDAC9 IRF4 JUN JUNB JUND KIFC3 LIMS3 MAPK1 MED17 MED6 MTA3 NCOR1 NCOR2 PELI1 PIN1 PML PPARD PRKD3 RAF1 RUNX1T1 SIAH1 SIN3A SP1 SPI1 TRAF1 WNK4 ZBTB16 ZBTB7A ZBTB7B
Entrez ID		57162	604
HPRD ID		17834	00180
Ensembl ID		ENSG00000197329	ENSG00000113916
Uniprot IDs		Q53T26 Q96FA3	B5B0A5 P41182
PDB IDs			1R28 1R29 1R2B 2EN2 2EOS 2LCE 2YRM 3BIM 3E4U 3LBZ
Enriched GO Terms of Interacting Partners?		Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Innate Immune Response Immune Response Immune Response-regulating Signaling Pathway Defense Response Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Immune System Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Immune System Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Stress Intracellular Signal Transduction Cellular Protein Modification Process Cellular Response To Stress Positive Regulation Of Intracellular Signal Transduction Regulation Of RNA Metabolic Process Positive Regulation Of Signal Transduction JNK Cascade Intracellular Receptor Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Signal Transduction Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Cellular Response To Stimulus Cellular Protein Metabolic Process Signaling Cell Communication	Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated RNA Metabolic Process Negative Regulation Of Biosynthetic Process Gene Expression Cellular Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Hemopoiesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Immune System Development Chromatin Organization Transcription Initiation From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Cell Differentiation Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Notch Signaling Pathway Immune System Process DNA-templated Transcription, Initiation Response To Organic Substance Leukocyte Differentiation Chromatin Modification Cellular Protein Modification Process Developmental Process Nitrogen Compound Metabolic Process Organ Development Chromosome Organization
Tagcloud ?		ablation abundantly autoimmune chemokines cns competent deficient e3 eae encephalomyelitis induction ligase lymphoid mediates mediator microglia microglial mitogen nervous neuroinflammation notably organs proinflammatory promotes restores sclerosis tlr toll traf3	ablated conducive cor corepressors deacteylases erbaalpha erbbeta interactiondomains laz3 locks mad mxi physicalassociation rev rid rids rip13a rip13delta1 rpd3 rvr sin3 sin3a sin3b tafii32 tafii70 tafs terminalrepression tfiib zip
Tagcloud (Difference) ?		ablation abundantly autoimmune chemokines cns competent deficient e3 eae encephalomyelitis induction ligase lymphoid mediates mediator microglia microglial mitogen nervous neuroinflammation notably organs proinflammatory promotes restores sclerosis tlr toll traf3	ablated conducive cor corepressors deacteylases erbaalpha erbbeta interactiondomains laz3 locks mad mxi physicalassociation rev rid rids rip13a rip13delta1 rpd3 rvr sin3 sin3a sin3b tafii32 tafii70 tafs terminalrepression tfiib zip
Tagcloud (Intersection) ?