NIF3L1 and SULT2A1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NIF3L1	SULT2A1
Description		NGG1 interacting factor 3 like 1	sulfotransferase family 2A member 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion	Cytoplasm Cytosol
	Molecular Function	Protein Binding Identical Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Alcohol Sulfotransferase Activity Protein Binding Sulfotransferase Activity Transferase Activity Bile-salt Sulfotransferase Activity Steroid Sulfotransferase Activity 3'-phosphoadenosine 5'-phosphosulfate Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Neuron Differentiation Positive Regulation Of DNA-templated Transcription	Ethanol Catabolic Process Lipid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Lipid Catabolic Process Bile Acid Catabolic Process Thyroid Hormone Metabolic Process 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Sulfation
Pathways			Cytosolic sulfonation of small molecules PPARA activates gene expression Paracetamol ADME
Drugs			Adenosine 3',5'-diphosphate Aetiocholanolone Mercuric iodide
Diseases
GWAS		Triptolide cytotoxicity ( 26121980)	Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) Cleft palate ( 30452639) Dehydroepiandrosterone sulphate levels ( 21533175) DHEAS levels ( 34748635) Estradiol levels ( 34255042) Gallstone disease ( 27094239 30504769) Liver enzyme levels (alkaline phosphatase) ( 33972514) Serum metabolite levels ( 23093944 33031748) Sex hormone levels ( 26014426) Triglyceride levels ( 32203549) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		93 interacting genes: ALKBH4 AP5B1 APIP ARPIN BDKRB2 BEND7 C14orf119 CASP7 CCDC102B CCDC85B CDKN2B CDKN2C CDKN2D COIL COPS2 CUTC CYRIB DCDC2 DCTD DCTPP1 DHPS DMC1 DMRTB1 DTX2 DUSP23 DUSP29 DYNLT3 EIF4A3 EIF5A2 ENOX1 EPHB6 FLAD1 FXR2 GNMT GRB2 IP6K3 KCNIP1 KCTD17 KCTD7 KCTD9 KRT15 KXD1 LAMTOR3 LMO2 LMO3 MAGEA11 MAPRE2 MLXIPL NATD1 NEK6 NGB NME1 NME7 NOL3 NUDT14 NUDT21 ORC5 PAFAH1B3 PAICS PCBD1 PNMA1 POLR1C PPIH PRTFDC1 PTPA RABAC1 RAD54B RPIA S100A1 SAT1 SEPTIN1 SNF8 SPG21 SSX2IP STAT3 STK16 SULT1A2 SULT1A3 SULT2A1 SYT17 TCL1A THOC7 TIFA TRAF2 TRIM21 TRIM27 TRIP13 TSC22D4 TXN VIM YES1 YWHAQ ZBED1	6 interacting genes: NIF3L1 PRDX4 STAT3 STK3 SULT1B1 TMX1
Entrez ID		60491	6822
HPRD ID		10424	00502
Ensembl ID		ENSG00000196290	ENSG00000105398
Uniprot IDs		Q9GZT8	A8K015 Q06520
PDB IDs			1EFH 1J99 1OV4 2QP3 2QP4 3F3Y 4IFB
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Cytoplasm Protein Binding Cytosol Protein Complex Oligomerization Nucleotide Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Ethanol Catabolic Process Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Ethanol Metabolic Process Nucleoside Phosphate Metabolic Process Phosphate-containing Compound Metabolic Process Sulfation Pyrimidine Nucleotide Metabolic Process Polyamine Catabolic Process Nucleus Ribose Phosphate Metabolic Process Reciprocal Meiotic Recombination	Uracil Binding Phosphate-containing Compound Metabolic Process Beta-alanine Metabolic Process Thymidine Catabolic Process Beta-alanine Biosynthetic Process Dihydropyrimidine Dehydrogenase (NADP+) Activity Regulation Of Developmental Growth Eating Behavior Regulation Of Multicellular Organism Growth Negative Regulation Of Multicellular Organismal Process Energy Homeostasis Response To Metformin Phosphorylation Pyrimidine Nucleoside Catabolic Process Thymine Metabolic Process Thymine Catabolic Process Uracil Catabolic Process Purine Nucleobase Catabolic Process Negative Regulation Of Primary MiRNA Processing Feeding Behavior Transforming Growth Factor Beta Receptor Signaling Pathway Protein Import Into Nucleus Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Skeletal Muscle Cell Proliferation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Developmental Growth I-kappaB Phosphorylation Negative Regulation Of Male Germ Cell Proliferation Import Into Nucleus CMP Catabolic Process DUMP Catabolic Process DCMP Catabolic Process UMP Catabolic Process RNA Sequestering Activity Regulation Of Growth Postsynapse To Nucleus Signaling Pathway Positive Regulation Of Small Molecule Metabolic Process T-helper 17 Type Immune Response Primitive Hemopoiesis Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Endocardium Development GDF15-GFRAL Signaling Pathway Thioredoxin-dependent Peroxiredoxin Activity Regulation Of Male Germ Cell Proliferation Negative Regulation Of Triglyceride Biosynthetic Process Deoxyribonucleoside Catabolic Process Negative Regulation Of Hydrogen Peroxide Metabolic Process Negative Regulation Of 3'-UTR-mediated MRNA Stabilization Interleukin-23-mediated Signaling Pathway
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