SMYD2 and HIST2H3C

Number of citations of the paper that reports this interaction (PMID 21678921)
2

Data Source:
BioGRID (enzymatic study)

		SMYD2	HIST2H3C
Gene Name		SET and MYND domain containing 2	histone cluster 2, H3c
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleosome Extracellular Region Nucleus Nucleoplasm Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Core Binding P53 Binding Protein Binding Protein-lysine N-methyltransferase Activity Metal Ion Binding Histone Methyltransferase Activity (H3-K36 Specific)	DNA Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Transcription, DNA-templated Negative Regulation Of Cell Proliferation Histone H3-K36 Methylation Peptidyl-lysine Monomethylation Peptidyl-lysine Dimethylation Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator	Chromatin Silencing At RDNA Blood Coagulation Gene Expression DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic
Pathways		Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines	RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase PKMTs methylate histone lysines Regulatory RNA pathways RNA Polymerase I Promoter Clearance HDMs demethylate histones Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression Factors involved in megakaryocyte development and platelet production PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: ESR1 HIST2H3C HSP90AA1 RB1 TP53	61 interactors: ARID4A ATRX AURKB BIRC5 BRD1 BRD4 BRD7 BRPF1 CDCA8 CDK8 CHUK COPRS DDB2 DNMT3L EHMT2 ELP3 EP300 HDGFRP2 INCENP ING1 JADE1 KAT2A KAT2B KAT5 KAT6A KDM1A KDM2A KDM3A KDM4C KDM6A KMT2A KMT2B KMT2C KMT2D MSL2 MUM1 NAP1L4 NASP NCOA6 NRD1 PHF21A PIM1 PKN1 PRMT6 PTMA RBBP4 RBBP5 RERE RNF20 RNF4 RPS6KA5 SETD1A SETD1B SETD7 SMARCA4 SMYD2 STAT6 TBL1X UHRF1 VRK1 WHSC1
Entrez ID		56950	126961
HPRD ID		15406	11822
Ensembl ID		ENSG00000143499
Uniprot IDs		Q9NRG4	Q71DI3
PDB IDs		3RIB 3S7B 3S7D 3S7F 3S7J 3TG4 3TG5	2IIJ 2X4W 2X4X 2X4Y 3AV1 3DB3 3MO8 3QO2 3R93
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Reactive Oxygen Species Metabolic Process Glial Cell Apoptotic Process Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Gene Expression Neuron Apoptotic Process Regulation Of Nitric Oxide Biosynthetic Process Mitochondrial Membrane Organization Neuron Death Regulation Of Reactive Oxygen Species Biosynthetic Process Intracellular Steroid Hormone Receptor Signaling Pathway Protein Localization To Organelle Positive Regulation Of Cellular Biosynthetic Process Regulation Of Oxidoreductase Activity Regulation Of Fibroblast Proliferation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Chromatin Organization Mitotic Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition Cell Cycle Arrest Mitochondrial Transport Negative Regulation Of Macromitophagy Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Oligodendrocyte Apoptotic Process Sister Chromatid Biorientation Regulation Of Nitrogen Compound Metabolic Process Protein Import Mitotic Cell Cycle Checkpoint Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Chromatin Remodeling Negative Regulation Of Helicase Activity Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Prostate Epithelial Cord Elongation Regulation Of Centromere Complex Assembly Positive Regulation Of Cellular Metabolic Process Intracellular Receptor Signaling Pathway Nitrogen Compound Metabolic Process Regulation Of Chromosome Organization Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Cycle Process Regulation Of Cohesin Localization To Chromatin Protein Import Into Mitochondrial Outer Membrane	Chromatin Modification Chromatin Organization Histone Modification Chromosome Organization Peptidyl-lysine Modification Organelle Organization Peptidyl-amino Acid Modification Transcription, DNA-templated RNA Biosynthetic Process Cellular Protein Modification Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression RNA Metabolic Process Histone Methylation Gene Expression Peptidyl-lysine Methylation Methylation Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Protein Methylation Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Histone Lysine Methylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Protein Acetylation Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Protein Metabolic Process Histone H3 Acetylation Positive Regulation Of Cellular Biosynthetic Process Histone H3-K4 Methylation Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression
Tagcloud ?		activates atg4a atg9a autophagy bix bix01294 deficiency detailed discovered dor elusive emerged enhances h3k9 induces inducing lc3 lc3b methyltransferase profiled promotes promoting puma rapamycin repressed screen selectively transcriptionally typical
Tagcloud (Difference) ?		activates atg4a atg9a autophagy bix bix01294 deficiency detailed discovered dor elusive emerged enhances h3k9 induces inducing lc3 lc3b methyltransferase profiled promotes promoting puma rapamycin repressed screen selectively transcriptionally typical
Tagcloud (Intersection) ?