SMYD2

Description		SET and MYND domain containing 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Complex Binding P53 Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Lysine N-methyltransferase Activity Protein-lysine N-methyltransferase Activity Transferase Activity Histone Methyltransferase Activity Metal Ion Binding Histone H3K36 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K4 Trimethyltransferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Heart Development Negative Regulation Of Cell Population Proliferation Peptidyl-lysine Monomethylation Peptidyl-lysine Dimethylation Methylation Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Signal Transduction By P53 Class Mediator
Pathways		PKMTs methylate histone lysines Regulation of TP53 Activity through Methylation
Drugs
Diseases
GWAS		Abdominal aortic aneurysm ( 27899403) Age at first sexual intercourse ( 34211149) Diverticular disease ( 30177863) Rheumatic heart disease ( 34106200) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		8 interacting genes: BTF3L4 ESR1 H3C14 HSP90AA1 HUNK RB1 SNX11 TP53
Entrez ID		56950
HPRD ID		15406
Ensembl ID		ENSG00000143499
Uniprot IDs		Q9NRG4
PDB IDs		3RIB 3S7B 3S7D 3S7F 3S7J 3TG4 3TG5 4O6F 4WUY 4YND 5ARF 5ARG 5KJK 5KJL 5KJM 5KJN 5V3H 5WCG 6CBX 6CBY 6MON 6N3G 9CKC 9CKF 9CKG
Enriched GO Terms of Interacting Partners?		Disordered Domain Specific Binding Glial Cell Apoptotic Process Nitric-oxide Synthase Regulator Activity Cardiac Muscle Cell Apoptotic Process Striated Muscle Cell Apoptotic Process Response To Salt Stress Muscle Cell Apoptotic Process Negative Regulation Of Glial Cell Proliferation Transcription Regulator Complex Protein Localization To Organelle 14-3-3 Protein Binding Chromatin Remodeling Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Fibroblast Proliferation Response To Antibiotic Regulation Of Chromosome Organization Glial Cell Proliferation Negative Regulation Of Gliogenesis Regulation Of Glial Cell Proliferation Regulation Of Telomere Maintenance Via Telomerase Macromolecule Biosynthetic Process Regulation Of Epithelial Cell Apoptotic Process Transcription Coactivator Binding Response To Xenobiotic Stimulus Regulation Of Telomere Maintenance Via Telomere Lengthening Ubiquitin Protein Ligase Binding Regulation Of Nitric Oxide Metabolic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of Nitric Oxide Biosynthetic Process Response To Estrogen Chromatin Organization CTP Binding Chromosome Organization DATP Binding Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Xenobiotic Stimulus Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Intracellular Protein Localization Response To Osmotic Stress Regulation Of MiRNA Transcription Negative Regulation Of Transcription By RNA Polymerase II Ras Protein Signal Transduction Enzyme Binding Regulation Of DNA Biosynthetic Process Regulation Of MiRNA Metabolic Process DNA-templated Transcription Regulation Of Fibroblast Proliferation
Tagcloud ?