SMYD2

Gene Name		SET and MYND domain containing 2
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Core Binding P53 Binding Protein Binding Protein-lysine N-methyltransferase Activity Metal Ion Binding Histone Methyltransferase Activity (H3-K36 Specific)
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Transcription, DNA-templated Negative Regulation Of Cell Proliferation Histone H3-K36 Methylation Peptidyl-lysine Monomethylation Peptidyl-lysine Dimethylation Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Pathways		Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines
Drugs
Diseases
GWAS
Protein-protein Interactions		5 interactors: ESR1 HIST2H3C HSP90AA1 RB1 TP53
Entrez ID		56950
HPRD ID		15406
Ensembl ID		ENSG00000143499
Uniprot IDs		Q9NRG4
PDB IDs		3RIB 3S7B 3S7D 3S7F 3S7J 3TG4 3TG5
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Reactive Oxygen Species Metabolic Process Glial Cell Apoptotic Process Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Gene Expression Neuron Apoptotic Process Regulation Of Nitric Oxide Biosynthetic Process Mitochondrial Membrane Organization Neuron Death Regulation Of Reactive Oxygen Species Biosynthetic Process Intracellular Steroid Hormone Receptor Signaling Pathway Protein Localization To Organelle Positive Regulation Of Cellular Biosynthetic Process Regulation Of Oxidoreductase Activity Regulation Of Fibroblast Proliferation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Chromatin Organization Mitotic Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition Cell Cycle Arrest Mitochondrial Transport Negative Regulation Of Macromitophagy Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Oligodendrocyte Apoptotic Process Sister Chromatid Biorientation Regulation Of Nitrogen Compound Metabolic Process Protein Import Mitotic Cell Cycle Checkpoint Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Chromatin Remodeling Negative Regulation Of Helicase Activity Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Prostate Epithelial Cord Elongation Regulation Of Centromere Complex Assembly Positive Regulation Of Cellular Metabolic Process Intracellular Receptor Signaling Pathway Nitrogen Compound Metabolic Process Regulation Of Chromosome Organization Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Cycle Process Regulation Of Cohesin Localization To Chromatin Protein Import Into Mitochondrial Outer Membrane
Tagcloud ?		activates atg4a atg9a autophagy bix bix01294 deficiency detailed discovered dor elusive emerged enhances h3k9 induces inducing lc3 lc3b methyltransferase profiled promotes promoting puma rapamycin repressed screen selectively transcriptionally typical