UBQLN1 and NPPA

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		UBQLN1	NPPA
Gene Name		ubiquilin 1	natriuretic peptide A
Image
Gene Ontology Annotations	Cellular Component	Proteasome Complex Nucleoplasm Cytoplasm Endoplasmic Reticulum Protein Complex Perinuclear Region Of Cytoplasm	Extracellular Region Extracellular Space Nucleus Mast Cell Granule Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Kinase Binding Protein Domain Specific Binding	Receptor Binding Neuropeptide Hormone Activity Peptide Hormone Receptor Binding Neuropeptide Receptor Binding
	Biological Process	Regulation Of Protein Ubiquitination Response To Endoplasmic Reticulum Stress Cellular Response To Hypoxia Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway	Response To Hypoxia Negative Regulation Of Systemic Arterial Blood Pressure CGMP Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Receptor Guanylyl Cyclase Signaling Pathway Neuropeptide Signaling Pathway Female Pregnancy Regulation Of Blood Pressure Positive Regulation Of Heart Rate Gene Expression Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Cell Growth Response To Insulin Response To Muscle Stretch Regulation Of Blood Vessel Size Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Positive Regulation Of Cardiac Muscle Contraction Cellular Response To Mechanical Stimulus Regulation Of High Voltage-gated Calcium Channel Activity Positive Regulation Of Delayed Rectifier Potassium Channel Activity Regulation Of Generation Of L-type Calcium Current
Pathways			Amyloids Generic Transcription Pathway YAP1- and WWTR1 (TAZ)-stimulated gene expression
Drugs
Diseases
GWAS			Atrial fibrillation ( 19597492) Systolic blood pressure ( 19430483)
Protein-Protein Interactions		151 interactors: ABCC2 ACOT7 ADRM1 AGPAT5 AGR2 AGR3 APP ASCL1 ATXN3 BPIFA1 C1QA C1QTNF2 CALU CARKD CCL7 CCNB1 CD47 CD99 CD99L2 CHGB CHRNA3 CHRNA4 CHRNB4 COL10A1 COL1A2 COLGALT2 COMTD1 CSTF2 CSTF2T CTAG1B CTAG2 CYB5R1 DEFA6 DNAJB2 EFEMP2 EP300 EPS15 ERP27 ETNK1 F8 FAM127A FAM127B FAM127C FAM189A2 FAM86B3P FAS FBXO25 FCGR2A FGF7 FKBP2 FN1 FZD7 GABRA1 GABRA2 GABRA3 GABRA6 GABRB1 GABRB2 GABRB3 GABRD GHRL GIT2 GKAP1 GPX3 GRM2 GYPB HERC3 HES1 HGS HK2 HSD17B12 HSPA13 IGL IGLC1 IGLV2-14 IL6ST IST1 ITPRIPL1 KLHL42 LITAF MANBAL MCM7 MIEF1 MIEF2 MLLT6 MTOR NBL1 NDE1 NGLY1 NME3 NPPA NPY NUPL1 P4HB PBXIP1 PIK3IP1 PLA2G16 PNMA1 PPIB PPIC PRAP1 PRB1 PRPF40A PSEN1 PSEN2 PSMD4 PSMD6 PTN RARA RASSF5 RIC8A RNF208 RPN1 RSRC2 SCG5 SCMH1 SERPINE1 SERPINI2 SIL1 SLC29A2 SMAD9 SMIM2 SMR3B SPARC SRGN STMN3 TARDBP TFF1 TICAM1 TMCO6 TMEM31 TMEM37 TMUB2 TNFRSF1A TNFRSF1B TREX1 TRIM32 TXNDC12 UBB UBC UBE2V1 UBQLN4 UBXN1 UBXN4 VCP XPO4 ZFAND2B ZG16 ZG16B ZMYM4 ZNF343	12 interactors: EPB41 ESR1 HNF4A MAGEA12 MME NPR1 NPR2 NPR3 NR5A2 RORB UBQLN1 UBQLN4
Entrez ID		29979	4878
HPRD ID		05440	00164
Ensembl ID		ENSG00000135018	ENSG00000175206
Uniprot IDs		Q9UMX0	P01160
PDB IDs		2JY5 2JY6 2KLC	1ANP 1YK0 3N57
Enriched GO Terms of Interacting Partners?		Response To Stress Response To Organic Substance Positive Regulation Of Proteolysis Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Response To Stimulus Regulation Of Protein Metabolic Process Cellular Response To Histamine Cellular Response To Organic Substance Cell-cell Signaling Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Synaptic Transmission Platelet Degranulation Signal Transduction Regulation Of Protein Ubiquitination Regulation Of Protein Catabolic Process Regulation Of ERBB Signaling Pathway Response To Histamine Chloride Transmembrane Transport Response To Organic Cyclic Compound Positive Regulation Of Protein Catabolic Process Signaling Cell Surface Receptor Signaling Pathway Response To Abiotic Stimulus Gamma-aminobutyric Acid Signaling Pathway Response To Hypoxia Cell Communication Chloride Transport Notch Signaling Pathway Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Immune System Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Cellular Response To Oxygen Levels Regulation Of Cellular Process Defense Response Positive Regulation Of Cell Cycle Cellular Response To Ammonium Ion Notch Receptor Processing Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway	Steroid Hormone Mediated Signaling Pathway Blood Circulation Hormone-mediated Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Regulation Of Blood Pressure Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Receptor Guanylyl Cyclase Signaling Pathway Positive Regulation Of Urine Volume Cellular Response To Organic Cyclic Compound CGMP Biosynthetic Process Positive Regulation Of Nitric-oxide Synthase Activity Cellular Response To Lipid Positive Regulation Of Monooxygenase Activity Response To Steroid Hormone CGMP Metabolic Process Cellular Response To Organic Substance Cellular Response To Hormone Stimulus Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Oxidoreductase Activity Cyclic Purine Nucleotide Metabolic Process Negative Regulation Of Smooth Muscle Cell Proliferation Cyclic Nucleotide Biosynthetic Process Endocrine Pancreas Development Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Cell Proliferation Response To Lipid Cyclic Nucleotide Metabolic Process Regulation Of Oxidoreductase Activity Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Response To Organic Cyclic Compound Response To Organic Substance Cellular Response To Stimulus Response To Hormone Pancreas Development Renal System Process Regulation Of Smooth Muscle Cell Proliferation Body Fluid Secretion Lipid Homeostasis Cellular Response To UV-A Negative Regulation Of Oocyte Maturation Prostate Epithelial Cord Elongation System Development Organ Development Positive Regulation Of Cholesterol Homeostasis Regulation Of Metabolic Process Negative Regulation Of Oocyte Development Regulation Of Growth Hormone Receptor Signaling Pathway
Tagcloud ?		affecting aid biomarkers biosynthesis contamination differentially elucidated evaluating exert exposed hepatic hepatotoxicity hnrnpc huwe1 itraq labeling ontology paf1 perfluorinated perfluorooctane pfos proteomic splicing sulfonate technology toxic transduction trigger whose	biventricle bv cardiomyogenic circuits combinatorial coordinately cpcs dimethylation dissect h3k27 h3k4 hampered hand1 hey hlhs hypoplastic ips maldevelopment malformations nkx2 notch1 pluripotency pluripotent reconstitute reprogrammed signatures sre tbx2 tnnt2
Tagcloud (Difference) ?		affecting aid biomarkers biosynthesis contamination differentially elucidated evaluating exert exposed hepatic hepatotoxicity hnrnpc huwe1 itraq labeling ontology paf1 perfluorinated perfluorooctane pfos proteomic splicing sulfonate technology toxic transduction trigger whose	biventricle bv cardiomyogenic circuits combinatorial coordinately cpcs dimethylation dissect h3k27 h3k4 hampered hand1 hey hlhs hypoplastic ips maldevelopment malformations nkx2 notch1 pluripotency pluripotent reconstitute reprogrammed signatures sre tbx2 tnnt2
Tagcloud (Intersection) ?