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UBQLN1 and UBA52
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
50
Data Source:
BioGRID
(two hybrid)
UBQLN1
UBA52
Description
ubiquilin 1
ubiquitin A-52 residue ribosomal protein fusion product 1
Image
GO Annotations
Cellular Component
Proteasome Complex
Nucleus
Nucleoplasm
Cytoplasm
Autophagosome
Endoplasmic Reticulum
Cytosol
Plasma Membrane
Membrane
Aggresome
Cytoplasmic Vesicle
Protein-containing Complex
Perinuclear Region Of Cytoplasm
Extracellular Space
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrial Outer Membrane
Lysosomal Membrane
Endoplasmic Reticulum Membrane
Cytosol
Ribosome
Plasma Membrane
Endosome Membrane
Large Ribosomal Subunit
Cytosolic Large Ribosomal Subunit
Cytosolic Ribosome
Endocytic Vesicle Membrane
Vesicle
Extracellular Exosome
Ribonucleoprotein Complex
Molecular Function
Protein Binding
Kinase Binding
Polyubiquitin Modification-dependent Protein Binding
Identical Protein Binding
Structural Constituent Of Ribosome
Protein Binding
Protein Tag Activity
Ubiquitin Protein Ligase Binding
Biological Process
Autophagosome Assembly
Ubiquitin-dependent Protein Catabolic Process
Autophagy
Macroautophagy
Regulation Of Macroautophagy
Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Ubiquitination
Negative Regulation Of Toll-like Receptor 3 Signaling Pathway
Response To Endoplasmic Reticulum Stress
Aggrephagy
ERAD Pathway
Negative Regulation Of Transport
Cellular Response To Hypoxia
Autophagosome Maturation
Negative Regulation Of Store-operated Calcium Channel Activity
Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of ERAD Pathway
Cytoplasmic Translation
Translation
Protein Ubiquitination
Response To Insecticide
Modification-dependent Protein Catabolic Process
Protein Modification Process
Pathways
Cargo recognition for clathrin-mediated endocytosis
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Activation of NF-kappaB in B cells
ISG15 antiviral mechanism
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
ER-Phagosome pathway
Downregulation of ERBB4 signaling
Spry regulation of FGF signaling
Downregulation of ERBB2:ERBB3 signaling
L13a-mediated translational silencing of Ceruloplasmin expression
Peptide chain elongation
Budding and maturation of HIV virion
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
DDX58/IFIH1-mediated induction of interferon-alpha/beta
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Membrane binding and targetting of GAG proteins
Assembly Of The HIV Virion
APC-Cdc20 mediated degradation of Nek2A
SRP-dependent cotranslational protein targeting to membrane
SRP-dependent cotranslational protein targeting to membrane
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
EGFR downregulation
SCF(Skp2)-mediated degradation of p27/p21
Viral mRNA Translation
Degradation of beta-catenin by the destruction complex
TCF dependent signaling in response to WNT
Downstream TCR signaling
NRIF signals cell death from the nucleus
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
Regulation of activated PAK-2p34 by proteasome mediated degradation
NOTCH1 Intracellular Domain Regulates Transcription
Activated NOTCH1 Transmits Signal to the Nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Downregulation of TGF-beta receptor signaling
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Selenocysteine synthesis
Separation of Sister Chromatids
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
Regulation of PLK1 Activity at G2/M Transition
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Stimuli-sensing channels
Constitutive Signaling by NOTCH1 HD Domain Mutants
FCERI mediated NF-kB activation
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
NOTCH2 Activation and Transmission of Signal to the Nucleus
Regulation of innate immune responses to cytosolic DNA
Glycogen synthesis
Autodegradation of the E3 ubiquitin ligase COP1
Deactivation of the beta-catenin transactivating complex
Myoclonic epilepsy of Lafora
ABC-family proteins mediated transport
TAK1-dependent IKK and NF-kappa-B activation
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Regulation of FZD by ubiquitination
PINK1-PRKN Mediated Mitophagy
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Regulation of TNFR1 signaling
TNFR1-induced NF-kappa-B signaling pathway
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Hedgehog 'on' state
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
Negative regulation of MAPK pathway
Regulation of necroptotic cell death
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAP3K8 (TPL2)-dependent MAPK1/3 activation
HDR through Homologous Recombination (HRR)
MAPK6/MAPK4 signaling
UCH proteinases
UCH proteinases
Josephin domain DUBs
Ub-specific processing proteases
Ovarian tumor domain proteases
Metalloprotease DUBs
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Processing of DNA double-strand break ends
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Fanconi Anemia Pathway
Major pathway of rRNA processing in the nucleolus and cytosol
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
Regulation of TP53 Activity through Methylation
Negative regulation of MET activity
Assembly of the pre-replicative complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Cyclin D associated events in G1
G2/M Checkpoints
Stabilization of p53
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Formation of a pool of free 40S subunits
GTP hydrolysis and joining of the 60S ribosomal subunit
Eukaryotic Translation Termination
Ubiquitin-dependent degradation of Cyclin D
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Downregulation of ERBB2 signaling
VLDLR internalisation and degradation
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
E3 ubiquitin ligases ubiquitinate target proteins
InlB-mediated entry of Listeria monocytogenes into host cell
InlB-mediated entry of Listeria monocytogenes into host cell
InlA-mediated entry of Listeria monocytogenes into host cells
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN localization
Regulation of PTEN stability and activity
Neddylation
ER Quality Control Compartment (ERQC)
Regulation of expression of SLITs and ROBOs
Regulation of expression of SLITs and ROBOs
NOTCH3 Activation and Transmission of Signal to the Nucleus
NOTCH3 Activation and Transmission of Signal to the Nucleus
TICAM1-dependent activation of IRF3/IRF7
TICAM1,TRAF6-dependent induction of TAK1 complex
Interleukin-1 signaling
Peroxisomal protein import
Peroxisomal protein import
Interferon alpha/beta signaling
Regulation of signaling by CBL
Endosomal Sorting Complex Required For Transport (ESCRT)
Iron uptake and transport
Negative regulators of DDX58/IFIH1 signaling
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
IRAK2 mediated activation of TAK1 complex
TRAF6-mediated induction of TAK1 complex within TLR4 complex
Negative regulation of NOTCH4 signaling
Chaperone Mediated Autophagy
Late endosomal microautophagy
Response of EIF2AK4 (GCN2) to amino acid deficiency
Prevention of phagosomal-lysosomal fusion
Modulation by Mtb of host immune system
Alpha-protein kinase 1 signaling pathway
Aggrephagy
Aggrephagy
RAS processing
Pexophagy
Signaling by CSF1 (M-CSF) in myeloid cells
Maturation of protein E
SARS-CoV-1 activates/modulates innate immune responses
Maturation of protein E
Inactivation of CSF3 (G-CSF) signaling
SARS-CoV-2 activates/modulates innate and adaptive immune responses
Negative regulation of FLT3
FLT3 signaling by CBL mutants
Regulation of BACH1 activity
Signaling by ALK fusions and activated point mutants
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
KEAP1-NFE2L2 pathway
Regulation of NF-kappa B signaling
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Degradation of CDH1
Amyloid fiber formation
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation
Antigen processing: Ubiquitination & Proteasome degradation
Evasion by RSV of host interferon responses
Regulation of pyruvate metabolism
GSK3B-mediated proteasomal degradation of PD-L1(CD274)
SPOP-mediated proteasomal degradation of PD-L1(CD274)
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
PD-L1(CD274) glycosylation and translocation to plasma membrane
Degradation of CRY and PER proteins
Degradation of CRY and PER proteins
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases
GWAS
Metabolite levels (
23823483
)
Refractive error (
32231278
)
Interacting Genes
233 interacting genes:
ABCC2
ACOT7
ADRM1
AGPAT5
AGR2
AGR3
ANOS1
APOC2
APOC4
APP
ASCL1
ATXN3
BAG6
BPIFA1
C1QA
C1QTNF2
C1QTNF4
CALU
CARINH
CCL3
CCL7
CD47
CD99
CD99L2
CDIP1
CDSN
CEBPA
CHGB
CHRNA3
CHRNA4
CHRNB4
CLCN2
COL10A1
COL1A2
COL9A2
COLGALT2
COMTD1
COPS4
CSN3
CSTF2
CSTF2T
CTAG1A
CTAG1B
CTAG2
CYB5R1
DAZAP2
DEFA6
DEFB115
DESI1
DEXI
DMKN
DNAJB2
DOLK
ECM1
EFEMP2
ENTREP1
EP300
EPS15
ERP27
ERP29
ETNK1
F8
FAM163B
FAM86B3P
FAS
FBXO25
FCGR2A
FGF7
FKBP2
FN1
FOLR3
FZD7
GABRA1
GABRA2
GABRA3
GABRA6
GABRB1
GABRB2
GABRB3
GABRD
GAL
GHRL
GIT2
GKAP1
GPR162
GPX3
GRM2
GUCA2A
GUCA2B
GYPB
HERC3
HES1
HGS
HK2
HSD17B12
HSPA13
IER3IP1
IGFBP6
IGL
IGLC1
IGLV2-14
IL6ST
IST1
ITPRIPL1
JPH4
JSRP1
KLHL42
LAIR2
LAMB1
LCN2
LHX4
LITAF
LNPEP
MANBAL
MAP3K1
MCM7
MDK
MESD
MICOS10-NBL1
MIEF1
MIEF2
MLLT6
MTNR1A
MTOR
MYDGF
NAXD
NBL1
NDE1
NDOR1
NEDD8
NGLY1
NLGN3
NME3
NPPA
NPY
NT5C3A
NUP58
NXF1
OST4
P4HB
PARVA
PBXIP1
PCDH18
PCDHA4
PIAS2
PIK3IP1
PLAAT1
PLAAT2
PLAAT3
PNMA1
PPIB
PPIC
PRAP1
PRB1
PRPF40A
PRR4
PSEN1
PSEN2
PSMD4
PSORS1C2
PTN
RAI2
RARA
RASSF5
RIC8A
RNF144B
RNF208
RNF4
RPN1
RPS27A
RSRC2
RTL8A
RTL8B
RTL8C
SCG2
SCG5
SCMH1
SERPINE1
SERPINI2
SEZ6L
SIL1
SLC16A3
SLC29A2
SLPI
SMAD9
SMIM19
SMIM2
SMR3B
SMURF1
SOD3
SPAG8
SPARC
SRGN
STAM2
STMN3
SUSD4
SYNJ2BP
TARDBP
TFF1
TICAM1
TLR4
TMCO6
TMEM258
TMEM37
TMEM67
TMUB2
TNFAIP3
TNFRSF1A
TNFRSF1B
TREX1
TRIM23
TRIM32
TXNDC12
UBA52
UBB
UBC
UBE2I
UBE2V1
UBQLN4
UBXN1
UBXN4
UBXN7
VWC2
WBP2
WFDC12
WWP2
XPO4
ZBTB8B
ZFAND2B
ZG16
ZG16B
ZMYM5
ZNF343
44 interacting genes:
ACVR1
ARRDC3
BMPR1B
DAZAP2
DESI1
DNAJB2
EPN2
EPN3
FAM168A
FILNC1
FNDC3B
FSHR
GRB2
HERC3
HGS
KHDRBS1
LAPTM5
LITAF
MAPK6
MTURN
NCK1
PLEKHB2
PLSCR4
POLI
RABGEF1
RAD23A
RNF11
SEC23B
SLC2A4
SMAD1
SMAD2
SMAD4
SMURF1
SNCA
SQSTM1
TAX1BP1
TGFBR1
TSG101
UBQLN1
UBQLN2
USP46
USP7
VPS28
WBP2
Entrez ID
29979
7311
HPRD ID
05440
08931
Ensembl ID
ENSG00000135018
ENSG00000221983
Uniprot IDs
Q9UMX0
P62987
Q3MIH3
Q7Z4P3
PDB IDs
2JY5
2JY6
2KLC
2LJ5
2MBH
2MJB
2MUR
2N3U
2N3V
2N3W
2NBD
2NBE
2RSU
4HJK
4JIO
4P4H
4PIG
4PIH
4PIJ
4RF0
4RF1
4S1Z
4UG0
4V6X
4XKL
5AJ0
5GO7
5GO8
5GOB
5GOC
5GOD
5GOG
5GOH
5GOI
5GOJ
5GOK
5HPK
5HPL
5HPS
5HPT
5J26
5J8P
5JBV
5JBY
5LKS
5T2C
6IP5
6IP6
6IP8
6LQM
6OLE
6OLF
6OLG
6OLI
6OLZ
6OM0
6OM7
6QZP
6XA1
6Y0G
6Y2L
6Y57
6Y6X
6Z6L
6Z6M
6Z6N
6ZM7
6ZME
6ZMI
6ZMO
7AY1
7BHP
7F5S
7M3Q
7OWC
7UN3
7WFC
7XD0
7XNX
7XNY
7ZF1
7ZH3
7ZH4
8A3D
8IFD
8IFE
8IK6
8IKM
8IKT
8IKV
8IPJ
8JDJ
8JDK
8JDL
8JDM
8K2C
8OHD
8OJ0
8OJ5
8OJ8
8QFD
8QOI
8QYX
8UKB
8XSX
8XSY
8XSZ
8Y0W
8Y0X
8YOO
8YOP
9C3H
9G8M
9GMO
Enriched GO Terms of Interacting Partners
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Extracellular Region
Extracellular Ligand-gated Monoatomic Ion Channel Activity
GABA-A Receptor Activity
GABA-A Receptor Complex
Protein Binding
Extracellular Space
GABA-gated Chloride Ion Channel Activity
Regulation Of Postsynaptic Membrane Potential
Gamma-aminobutyric Acid Signaling Pathway
Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
Postsynaptic Specialization Membrane
Synaptic Transmission, GABAergic
Endoplasmic Reticulum Lumen
Chloride Channel Complex
Chloride Channel Activity
Inhibitory Synapse Assembly
Postsynaptic Membrane
Positive Regulation Of Glial Cell Differentiation
Polyubiquitin Modification-dependent Protein Binding
Proteolysis Involved In Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Protein Tag Activity
Regulation Of Membrane Potential
Transmembrane Signaling Receptor Activity
Cell-cell Signaling
Endoplasmic Reticulum
Behavioral Response To Nicotine
Regulation Of Tumor Necrosis Factor Production
Regulation Of Mononuclear Cell Migration
Regulation Of Proteolysis
Synaptic Signaling
Signaling
Chemical Synaptic Transmission
Positive Regulation Of Oligodendrocyte Differentiation
Chloride Transmembrane Transport
Benzodiazepine Receptor Activity
Ubiquitin Binding
GABA-ergic Synapse
Proteolysis
Monoatomic Anion Transmembrane Transport
Macromolecule Catabolic Process
Cell Communication
Regulation Of Oligodendrocyte Differentiation
Regulation Of Leukocyte Migration
Chloride Transport
Trans-synaptic Signaling
Monoatomic Ion Channel Activity
Oligosaccharyltransferase Complex
Positive Regulation Of Nervous System Development
Monoatomic Anion Transport
Endosome
I-SMAD Binding
SMAD Binding
Regulation Of Signal Transduction
Regulation Of Protein Metabolic Process
Establishment Of Protein Localization To Vacuole
Regulation Of Cell Communication
Regulation Of Signaling
Negative Regulation Of Signal Transduction
Regulation Of Protein Catabolic Process
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Positive Regulation Of Metabolic Process
Protein Localization To Vacuole
Transforming Growth Factor Beta Receptor Activity, Type I
Ubiquitin Binding
Protein-containing Complex
Positive Regulation Of Macromolecule Metabolic Process
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
SMAD Protein Complex
Regulation Of Protein Ubiquitination
Heteromeric SMAD Protein Complex
Ubiquitin Protein Ligase Binding
Cytoplasm
Activin Receptor Signaling Pathway
Positive Regulation Of Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Regulation Of Primary Metabolic Process
Modification-dependent Protein Catabolic Process
BMP Signaling Pathway
Polyubiquitin Modification-dependent Protein Binding
Regulation Of Post-translational Protein Modification
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Vacuolar Transport
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Protein Sequestering Activity
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Proteolysis
Proteolysis
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Homomeric SMAD Protein Complex
Positive Regulation Of Ubiquitin-dependent Endocytosis
Regulation Of Metabolic Process
Proteolysis Involved In Protein Catabolic Process
Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Protein Targeting To Vacuole
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