UBQLN1 and FAS

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		UBQLN1	FAS
Description		ubiquilin 1	Fas cell surface death receptor
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GO Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Autophagosome Endoplasmic Reticulum Cytosol Plasma Membrane Membrane Aggresome Cytoplasmic Vesicle Protein-containing Complex Perinuclear Region Of Cytoplasm	Extracellular Region Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Nuclear Body Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Membrane Raft Extracellular Exosome
	Molecular Function	Protein Binding Kinase Binding Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding	Transmembrane Signaling Receptor Activity Tumor Necrosis Factor Receptor Activity Protein Binding Calmodulin Binding Kinase Binding Signaling Receptor Activity Identical Protein Binding
	Biological Process	Autophagosome Assembly Ubiquitin-dependent Protein Catabolic Process Autophagy Macroautophagy Regulation Of Macroautophagy Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Response To Endoplasmic Reticulum Stress Aggrephagy ERAD Pathway Negative Regulation Of Transport Cellular Response To Hypoxia Autophagosome Maturation Negative Regulation Of Store-operated Calcium Channel Activity Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of ERAD Pathway	Apoptotic Process Activation-induced Cell Death Of T Cells Immune Response Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Stress-activated MAPK Cascade Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Amino Acid Starvation Fas Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Protein-containing Complex Assembly Cellular Response To Mechanical Stimulus Cellular Response To Hyperoxia Motor Neuron Apoptotic Process Extrinsic Apoptotic Signaling Pathway Necroptotic Signaling Pathway Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Cargo recognition for clathrin-mediated endocytosis	Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TP53 Regulates Transcription of Death Receptors and Ligands Dimerization of procaspase-8 FasL/ CD95L signaling
Drugs
Diseases			Esophageal cancer Chronic lymphocytic leukemia (CLL) Hodgkin lymphoma Adult T-cell leukemia
GWAS		Metabolite levels ( 23823483) Refractive error ( 32231278)	Ankylosing spondylitis ( 30946743) Atrioventricular conduction ( 21041692) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Chronic lymphocytic leukemia ( 23770605 24292274 26956414 28165464) Immunoglobulin A ( 20694011) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Mosquito bite size ( 28199695) Obesity-related traits ( 23251661) Red blood cell count ( 32888494) Selective IgA deficiency ( 27723758)
Interacting Genes		233 interacting genes: ABCC2 ACOT7 ADRM1 AGPAT5 AGR2 AGR3 ANOS1 APOC2 APOC4 APP ASCL1 ATXN3 BAG6 BPIFA1 C1QA C1QTNF2 C1QTNF4 CALU CARINH CCL3 CCL7 CD47 CD99 CD99L2 CDIP1 CDSN CEBPA CHGB CHRNA3 CHRNA4 CHRNB4 CLCN2 COL10A1 COL1A2 COL9A2 COLGALT2 COMTD1 COPS4 CSN3 CSTF2 CSTF2T CTAG1A CTAG1B CTAG2 CYB5R1 DAZAP2 DEFA6 DEFB115 DESI1 DEXI DMKN DNAJB2 DOLK ECM1 EFEMP2 ENTREP1 EP300 EPS15 ERP27 ERP29 ETNK1 F8 FAM163B FAM86B3P FAS FBXO25 FCGR2A FGF7 FKBP2 FN1 FOLR3 FZD7 GABRA1 GABRA2 GABRA3 GABRA6 GABRB1 GABRB2 GABRB3 GABRD GAL GHRL GIT2 GKAP1 GPR162 GPX3 GRM2 GUCA2A GUCA2B GYPB HERC3 HES1 HGS HK2 HSD17B12 HSPA13 IER3IP1 IGFBP6 IGL IGLC1 IGLV2-14 IL6ST IST1 ITPRIPL1 JPH4 JSRP1 KLHL42 LAIR2 LAMB1 LCN2 LHX4 LITAF LNPEP MANBAL MAP3K1 MCM7 MDK MESD MICOS10-NBL1 MIEF1 MIEF2 MLLT6 MTNR1A MTOR MYDGF NAXD NBL1 NDE1 NDOR1 NEDD8 NGLY1 NLGN3 NME3 NPPA NPY NT5C3A NUP58 NXF1 OST4 P4HB PARVA PBXIP1 PCDH18 PCDHA4 PIAS2 PIK3IP1 PLAAT1 PLAAT2 PLAAT3 PNMA1 PPIB PPIC PRAP1 PRB1 PRPF40A PRR4 PSEN1 PSEN2 PSMD4 PSORS1C2 PTN RAI2 RARA RASSF5 RIC8A RNF144B RNF208 RNF4 RPN1 RPS27A RSRC2 RTL8A RTL8B RTL8C SCG2 SCG5 SCMH1 SERPINE1 SERPINI2 SEZ6L SIL1 SLC16A3 SLC29A2 SLPI SMAD9 SMIM19 SMIM2 SMR3B SMURF1 SOD3 SPAG8 SPARC SRGN STAM2 STMN3 SUSD4 SYNJ2BP TARDBP TFF1 TICAM1 TLR4 TMCO6 TMEM258 TMEM37 TMEM67 TMUB2 TNFAIP3 TNFRSF1A TNFRSF1B TREX1 TRIM23 TRIM32 TXNDC12 UBA52 UBB UBC UBE2I UBE2V1 UBQLN4 UBXN1 UBXN4 UBXN7 VWC2 WBP2 WFDC12 WWP2 XPO4 ZBTB8B ZFAND2B ZG16 ZG16B ZMYM5 ZNF343	50 interacting genes: ANK3 APAF1 APOA5 ATP6V0B BAG6 BTK CALM1 CASP8 CASP8AP2 CCND3 CD47 CRMP1 DAXX DNAJC5 EEF1A1 EGFR ERG28 EZR FADD FAF1 FAF2 FAIM2 FASLG FBF1 FEM1B FYN GADD45A HIPK3 HNRNPC LCK LRIF1 MBD4 MET PDCD6 PRKCA PTPN13 PTPN6 RAP1A RIPK1 SUMO1 TCAP TMX1 TNFSF13 TRADD TRAF3 TRIP6 UBA7 UBAC1 UBE2I UBQLN1
Entrez ID		29979	355
HPRD ID		05440	00609
Ensembl ID		ENSG00000135018	ENSG00000026103
Uniprot IDs		Q9UMX0	A0A8Q3SIR6 K9J972 P25445 Q59FU8
PDB IDs		2JY5 2JY6 2KLC	1DDF 2NA7 3EWT 3EZQ 3THM 3TJE
Enriched GO Terms of Interacting Partners?		Extracellular Region Extracellular Ligand-gated Monoatomic Ion Channel Activity GABA-A Receptor Activity GABA-A Receptor Complex Protein Binding Extracellular Space GABA-gated Chloride Ion Channel Activity Regulation Of Postsynaptic Membrane Potential Gamma-aminobutyric Acid Signaling Pathway Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Postsynaptic Specialization Membrane Synaptic Transmission, GABAergic Endoplasmic Reticulum Lumen Chloride Channel Complex Chloride Channel Activity Inhibitory Synapse Assembly Postsynaptic Membrane Positive Regulation Of Glial Cell Differentiation Polyubiquitin Modification-dependent Protein Binding Proteolysis Involved In Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Tag Activity Regulation Of Membrane Potential Transmembrane Signaling Receptor Activity Cell-cell Signaling Endoplasmic Reticulum Behavioral Response To Nicotine Regulation Of Tumor Necrosis Factor Production Regulation Of Mononuclear Cell Migration Regulation Of Proteolysis Synaptic Signaling Signaling Chemical Synaptic Transmission Positive Regulation Of Oligodendrocyte Differentiation Chloride Transmembrane Transport Benzodiazepine Receptor Activity Ubiquitin Binding GABA-ergic Synapse Proteolysis Monoatomic Anion Transmembrane Transport Macromolecule Catabolic Process Cell Communication Regulation Of Oligodendrocyte Differentiation Regulation Of Leukocyte Migration Chloride Transport Trans-synaptic Signaling Monoatomic Ion Channel Activity Oligosaccharyltransferase Complex Positive Regulation Of Nervous System Development Monoatomic Anion Transport	Cell Death Regulation Of Programmed Cell Death Apoptotic Process Programmed Cell Death Regulation Of Apoptotic Process Apoptotic Signaling Pathway Death Receptor Binding Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Death-inducing Signaling Complex Regulation Of Protein Metabolic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cytosol Regulation Of Cell Communication Cytoplasm Regulation Of Signaling Tumor Necrosis Factor Receptor Binding Extrinsic Apoptotic Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Metabolic Process Positive Regulation Of Macrophage Differentiation Signal Transduction Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Signaling Pathway Ubiquitin Protein Ligase Binding Positive Regulation Of Cell Communication Positive Regulation Of Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Extrinsic Apoptotic Signaling Pathway Ripoptosome CD95 Death-inducing Signaling Complex Positive Regulation Of Intracellular Signal Transduction Kinase Binding Regulation Of Macrophage Differentiation Regulation Of Primary Metabolic Process Negative Regulation Of Transporter Activity Identical Protein Binding Regulation Of Protein Catabolic Process Positive Regulation Of Signaling Response To Mechanical Stimulus Necroptotic Signaling Pathway TRAIL-activated Apoptotic Signaling Pathway Protein Tyrosine Kinase Activity Regulation Of Multicellular Organismal Process Regulation Of Immune Response Positive Regulation Of Protein Metabolic Process Protein-macromolecule Adaptor Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Phospholipase Activator Activity
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