WFS1 and ADRA2C

		WFS1	ADRA2C
Description		wolframin ER transmembrane glycoprotein	adrenoceptor alpha 2C
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane Transport Vesicle Secretory Granule Dendrite Synaptic Vesicle Membrane Cytoplasmic Vesicle	Cytoplasm Endosome Plasma Membrane Membrane
	Molecular Function	Protein Binding Calmodulin Binding Ubiquitin Protein Ligase Binding Calcium-dependent Protein Binding ATPase Binding Proteasome Binding DNA-binding Transcription Factor Binding Protein Carrier Chaperone	G Protein-coupled Receptor Activity Adrenergic Receptor Activity Alpha2-adrenergic Receptor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Alpha-2A Adrenergic Receptor Binding Protein Homodimerization Activity Protein Heterodimerization Activity Epinephrine Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Kidney Development Renal Water Homeostasis ER Overload Response Visual Perception Sensory Perception Of Sound Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation Endoplasmic Reticulum Unfolded Protein Response Pancreas Development Positive Regulation Of Protein Ubiquitination Endoplasmic Reticulum Calcium Ion Homeostasis Response To Endoplasmic Reticulum Stress Intracellular Signal Transduction ERAD Pathway Olfactory Behavior Glucose Homeostasis Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Growth Protein Stabilization Nervous System Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Calcium Ion Transport Calcium Ion Homeostasis Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of ATF6-mediated Unfolded Protein Response Positive Regulation Of ERAD Pathway Negative Regulation Of Type B Pancreatic Cell Apoptotic Process	Regulation Of Smooth Muscle Contraction Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Negative Regulation Of Norepinephrine Secretion Regulation Of Vasoconstriction Platelet Activation Negative Regulation Of Epinephrine Secretion Positive Regulation Of MAPK Cascade Positive Regulation Of Neuron Differentiation Negative Regulation Of Insulin Secretion Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Adrenergic Receptor Signaling Pathway
Pathways		XBP1(S) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Adrenoceptors Adrenaline signalling through Alpha-2 adrenergic receptor Adrenaline,noradrenaline inhibits insulin secretion G alpha (i) signalling events G alpha (z) signalling events Surfactant metabolism
Drugs			Amphetamine Tramadol Bethanidine Ziprasidone Cabergoline Ropinirole Dihydroergotamine Clozapine Norepinephrine Phenylpropanolamine Loxapine Prochlorperazine Chlorpromazine Brimonidine Haloperidol Nortriptyline Amoxapine Clonidine Lisuride Ergotamine Tizanidine Apomorphine Paroxetine Risperidone Tolazoline Fenoldopam Phenoxybenzamine Maprotiline Oxymetazoline Ergoloid mesylate Promethazine Carvedilol Desipramine Escitalopram Pergolide Bromocriptine Quetiapine Aripiprazole Paliperidone Ephedra sinica root Mephentermine Yohimbine Methotrimeprazine Dextroamphetamine Metamfetamine Celiprolol Dronedarone Iloperidone OPC-28326 Epicept NP-1 Mianserin Pizotifen Asenapine Ocaperidone Droxidopa Esmirtazapine Xylometazoline Levonordefrin Tetryzoline Lurasidone Agmatine Brexpiprazole Dosulepin Etoperidone Lorpiprazole Cirazoline Moxisylyte Aranidipine Setiptiline Racepinephrine Dihydroergocornine DL-Methylephedrine Xylazine Indigotindisulfonic acid Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases		Wolfram syndrome (WFS); DIDMOAD syndrome Type II diabetes mellitus
GWAS		Cisplatin-induced ototoxicity ( 28039263) High density lipoprotein cholesterol levels ( 32902719) Medication use (drugs used in diabetes) ( 31015401) Mild age-related type 2 diabetes ( 34737425) Type 2 diabetes ( 20581827 32499647 31118516 30718926 30297969 30054458 29632382 29358691 28869590 24509480 22885922 19734900) Type 2 diabetes (adjusted for BMI) ( 29632382)	Blood urea nitrogen levels ( 31152163) Lung cancer in ever smokers ( 28604730) Nickel levels ( 26025379) Urinary potassium excretion ( 31409800)
Interacting Genes		11 interacting genes: AQP6 CD79A DRD2 EIF6 F2RL1 FAM209A LTB4R2 MAPK6 SMURF1 TERF1 TRARG1	17 interacting genes: CCDC24 CHCHD2 CNPY2 EIF2B1 GNAO1 HGS KLHL38 KRT34 MDFI MEIS2 MGAT5B MKRN3 P4HA3 PPP1R9B UCHL1 WWOX YWHAZ
Entrez ID		7466	152
HPRD ID		05864	00085
Ensembl ID		ENSG00000109501	ENSG00000184160
Uniprot IDs		A0A0S2Z4V6 O76024	P18825 Q4W594
PDB IDs			6KUW
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Insulin Secretion Negative Regulation Of Establishment Of Protein Localization Negative Regulation Of Peptide Secretion Negative Regulation Of Hormone Secretion Negative Regulation Of Protein Secretion Negative Regulation Of Catecholamine Secretion Negative Regulation Of Protein Transport Renal System Process Negative Regulation Of Secretion By Cell G Protein-coupled Receptor Activity G-protein Alpha-subunit Binding Regulation Of Insulin Secretion Negative Regulation Of Secretion Regulation Of Catecholamine Secretion Regulation Of Peptide Hormone Secretion Nitrate Transmembrane Transporter Activity Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Protein Localization To Plasma Membrane Assembly Of Large Subunit Precursor Of Preribosome Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Engulfment Of Target By Autophagosome Negative Regulation Of Protein Localization Regulation Of Establishment Of Protein Localization PH-gated Chloride Channel Activity Nitrate Transmembrane Transport G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Proteinase-activated Receptor Activity Positive Regulation Of Eosinophil Degranulation Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Protein Localization To Cell Periphery Septin Cytoskeleton Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Leukotriene B4 Receptor Activity Regulation Of Hormone Secretion Regulation Of Protein Secretion Regulation Of Amine Transport Alpha2-adrenergic Receptor Activity Regulation Of Body Fluid Levels Negative Regulation Of Activation Of Membrane Attack Complex IgM B Cell Receptor Complex Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development Negative Regulation Of Dopamine Receptor Signaling Pathway
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