PTGIS and ARFGEF2

		PTGIS	ARFGEF2
Description		prostaglandin I2 synthase	ARF guanine nucleotide exchange factor 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Caveola Membrane	Golgi Membrane Cytoplasm Endosome Golgi Apparatus Trans-Golgi Network Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Axonemal Microtubule Membrane Dendrite Cytoplasmic Vesicle Asymmetric Synapse Symmetric Synapse Cell Projection Dendritic Spine Synapse Perinuclear Region Of Cytoplasm Recycling Endosome Presynapse Postsynapse Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Monooxygenase Activity Iron Ion Binding Protein Binding Prostaglandin-I Synthase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Lyase Activity Isomerase Activity Heme Binding Metal Ion Binding Hydroperoxy Icosatetraenoate Dehydratase Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding Myosin Binding Protein Kinase A Regulatory Subunit Binding GABA Receptor Binding
	Biological Process	Prostaglandin Biosynthetic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Icosanoid Metabolic Process Prostaglandin Metabolic Process Embryo Implantation NAD+ Biosynthetic Process Via The Salvage Pathway Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Prostanoid Biosynthetic Process Decidualization Negative Regulation Of Inflammatory Response Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Hypoxia Apoptotic Signaling Pathway Positive Regulation Of Execution Phase Of Apoptosis	Receptor Recycling Exocytosis Golgi To Plasma Membrane Transport Endosome Organization Endomembrane System Organization Protein Transport Vesicle-mediated Transport Regulation Of ARF Protein Signal Transduction Positive Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction
Pathways		Eicosanoids Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	Association of TriC/CCT with target proteins during biosynthesis
Drugs		Phenylbutazone Epoprostenol (5Z)-7-{(1R,4S,5R,6R)-6-[(1E)-1-Octen-1-yl]-2,3-diazabicyclo[2.2.1]hept-2-en-5-yl}-5-heptenoic acid
Diseases			Periventricular nodular heterotopia (PVNH)
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Schizophrenia ( 25056061 29483656 30285260)	Adult body size ( 32376654) Anger ( 24489884) Birth weight ( 31043758) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Intelligence (MTAG) ( 29326435) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Offspring birth weight ( 31043758) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		3 interacting genes: APP PTGS1 PTGS2	10 interacting genes: ARFGEF1 EXOC7 GABRB1 GABRB2 GABRB3 LCOR PNPLA2 PRKAR1A PRKAR2A PRPF40A
Entrez ID		5740	10564
HPRD ID		09046	09250
Ensembl ID		ENSG00000124212	ENSG00000124198
Uniprot IDs		Q16647	A0A7P0T7Z2 Q59FR3 Q86TH5 Q9Y6D5
PDB IDs		2IAG 3B6H	3L8N 3SWV
Enriched GO Terms of Interacting Partners?		Cyclooxygenase Pathway Prostaglandin-endoperoxide Synthase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Cellular Response To Catecholamine Stimulus Response To Catecholamine Prostaglandin Biosynthetic Process Prostanoid Biosynthetic Process Peroxidase Activity Cellular Response To Fluid Shear Stress Prostaglandin Metabolic Process Prostanoid Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Metabolic Process Response To Fluid Shear Stress Arachidonate Metabolic Process Unsaturated Fatty Acid Biosynthetic Process Icosanoid Biosynthetic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Response To Calcium Ion Perinuclear Region Of Cytoplasm Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Response To Non-ionic Osmotic Stress Regulation Of Multicellular Organism Growth Regulation Of Nitric Oxide Metabolic Process Neuron Projection Dioxygenase Activity Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Tumor Necrosis Factor Production Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Inflammatory Response Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Protein Localization To Endoplasmic Reticulum Nascent Polypeptide-associated Complex Secretion By Cell Mu-type Opioid Receptor Binding Regulation Of Cholangiocyte Proliferation Cellular Detoxification Unsaturated Fatty Acid Metabolic Process	Cellular Response To Histamine Response To Histamine GABA-A Receptor Activity GABA-gated Chloride Ion Channel Activity GABA-A Receptor Complex Gamma-aminobutyric Acid Signaling Pathway Postsynaptic Specialization Membrane Synaptic Transmission, GABAergic Extracellular Ligand-gated Monoatomic Ion Channel Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Chloride Channel Complex CAMP-dependent Protein Kinase Regulator Activity Chloride Channel Activity CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Inhibitor Activity Nucleotide-activated Protein Kinase Complex Inner Ear Receptor Cell Development Chloride Transmembrane Transport Regulation Of Postsynaptic Membrane Potential Protein Kinase A Catalytic Subunit Binding GABA-ergic Synapse Chloride Transport Inorganic Anion Transmembrane Transport Regulation Of Biological Quality Innervation CAMP Binding Monoatomic Anion Transmembrane Transport Inorganic Anion Transport Monoatomic Anion Transport Inhibitory Synapse Assembly Negative Regulation Of CAMP/PKA Signal Transduction Monoatomic Ion Channel Activity Neuron Development Cochlea Development Plasma Membrane Raft Membrane Ciliary Base Transmembrane Signaling Receptor Activity Regulation Of CAMP/PKA Signal Transduction Postsynaptic Membrane Transmembrane Transport Circadian Sleep/wake Cycle, REM Sleep Prostaglandin-I Synthase Activity Inorganic Ion Transmembrane Transport Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Presynaptic Membrane Potential Trans-synaptic Signaling Synaptic Signaling Regulation Of Cytokinesis
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