PTGIS and BTF3

Data Source: HiPPIP (Novel)

		PTGIS	BTF3
Name		prostaglandin I2 synthase	basic transcription factor 3
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Caveola Membrane	Nucleus Cytoplasm Cytosol Nascent Polypeptide-associated Complex
	Molecular Function	Monooxygenase Activity Iron Ion Binding Protein Binding Prostaglandin-I Synthase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Lyase Activity Isomerase Activity Heme Binding Metal Ion Binding Hydroperoxy Icosatetraenoate Dehydratase Activity	RNA Binding Protein Binding
	Biological Process	Prostaglandin Biosynthetic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Icosanoid Metabolic Process Prostaglandin Metabolic Process Embryo Implantation NAD+ Biosynthetic Process Via The Salvage Pathway Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Prostanoid Biosynthetic Process Decidualization Negative Regulation Of Inflammatory Response Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Hypoxia Apoptotic Signaling Pathway Positive Regulation Of Execution Phase Of Apoptosis	In Utero Embryonic Development Protein Transport Negative Regulation Of Protein Localization To Endoplasmic Reticulum
Pathways		Eicosanoids Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	None
Drugs		Phenylbutazone Epoprostenol (5Z)-7-{(1R,4S,5R,6R)-6-[(1E)-1-Octen-1-yl]-2,3-diazabicyclo[2.2.1]hept-2-en-5-yl}-5-heptenoic acid	None
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Schizophrenia ( 25056061 29483656 30285260 )	Eyebrow thickness ( 26926045 ) Monobrow thickness ( 26926045 )
Novel Interactors		7 novel interactors: ARFGEF2 BTF3 GMFG GNAS LTB4R2 PKHD1 TMSB4XP6	2 novel interactors: PTGIS USP16
Interacting Genes		3 interacting genes: APP PTGS1 PTGS2	12 interacting genes: APP CDC42 CEBPA CSNK2B IFTAP MED21 NMT2 NOTO POLR2B TXLNA TXLNB ZDHHC17
Entrez ID		5740	689
HPRD ID		09046	03966
Ensembl ID		ENSG00000124212	ENSG00000145741
Uniprot IDs		Q16647	P20290
PDB IDs		2IAG 3B6H	3LKX 3MCB 7QWQ 7QWR 9F1B 9F1C 9F1D 9FQ0
GO Terms Enriched among Interactors		Cyclooxygenase Pathway Prostaglandin-endoperoxide Synthase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Cellular Response To Catecholamine Stimulus Response To Catecholamine Prostaglandin Biosynthetic Process Prostanoid Biosynthetic Process Peroxidase Activity Cellular Response To Fluid Shear Stress Prostaglandin Metabolic Process Prostanoid Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Metabolic Process Response To Fluid Shear Stress Arachidonate Metabolic Process Unsaturated Fatty Acid Biosynthetic Process Icosanoid Biosynthetic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Response To Calcium Ion Perinuclear Region Of Cytoplasm Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Response To Non-ionic Osmotic Stress Regulation Of Multicellular Organism Growth Regulation Of Nitric Oxide Metabolic Process Neuron Projection Dioxygenase Activity Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Tumor Necrosis Factor Production Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Inflammatory Response Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Protein Localization To Endoplasmic Reticulum Nascent Polypeptide-associated Complex Secretion By Cell Mu-type Opioid Receptor Binding Regulation Of Cholangiocyte Proliferation Cellular Detoxification Unsaturated Fatty Acid Metabolic Process	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Response To Interleukin-1 Cell Projection Morphogenesis Growth Cone Lamellipodium Neuron Projection Organization Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Synapse Organization Regulation Of Response To Calcium Ion Amylin Binding Neuron Projection Morphogenesis Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Response To Peptide Positive Regulation Of Intracellular Signal Transduction Response To Cytokine Lipoprotein Particle Chromatin Binding Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of G Protein-coupled Receptor Internalization Macrophage Differentiation Endothelin Receptor Signaling Pathway Involved In Heart Process GBD Domain Binding Storage Vacuole Positive Regulation Of DNA-templated Transcription Initiation CHOP-C/EBP Complex Regulation Of DNA-templated Transcription Initiation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Ribonucleoside Binding RNA-directed RNA Polymerase Activity RNA-templated Transcription DNA-directed RNA Polymerase Activity Prostaglandin-I Synthase Activity Glycylpeptide N-tetradecanoyltransferase Activity Protein Lipidation N-terminal Peptidyl-glycine N-myristoylation Peptidyl-lysine N6-myristoyltransferase Activity Positive Regulation Of Ribosome Biogenesis