PTGIS

Gene Name		prostaglandin I2 (prostacyclin) synthase
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Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Caveola Integral Component Of Membrane
	Molecular Function	Monooxygenase Activity Iron Ion Binding Protein Binding Prostaglandin-I Synthase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Heme Binding
	Biological Process	Prostaglandin Biosynthetic Process Icosanoid Metabolic Process Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Nicotinamide Metabolic Process Xenobiotic Metabolic Process Arachidonic Acid Metabolic Process Cyclooxygenase Pathway NAD Metabolic Process Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Small Molecule Metabolic Process Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Oxidation-reduction Process Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Hypoxia Apoptotic Signaling Pathway Positive Regulation Of Execution Phase Of Apoptosis
Pathways		Metabolism of vitamins and cofactors Bile acid and bile salt metabolism Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Metabolism of lipids and lipoproteins Defective BTD causes biotidinase deficiency Metabolic disorders of biological oxidation enzymes Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Arachidonic acid metabolism Defective AMN causes hereditary megaloblastic anemia 1 Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Endogenous sterols Synthesis of bile acids and bile salts Synthesis of bile acids and bile salts via 24-hydroxycholesterol Defective GIF causes intrinsic factor deficiency Defective FMO3 causes Trimethylaminuria (TMAU) Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Eicosanoids Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Synthesis of bile acids and bile salts via 27-hydroxycholesterol Defective MAOA causes Brunner syndrome (BRUNS) Defects in biotin (Btn) metabolism Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3) Defective TCN2 causes hereditary megaloblastic anemia Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Phase 1 - Functionalization of compounds Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Cytochrome P450 - arranged by substrate type Nicotinamide salvaging Biological oxidations Sterols are 12-hydroxylated by CYP8B1 Defects in cobalamin (B12) metabolism Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective CYP1B1 causes Glaucoma Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Nicotinate metabolism Defects in vitamin and cofactor metabolism
Drugs		Phenylbutazone Epoprostenol (6E)-7-{6-[(1E)-OCT-1-ENYL]-2,3-DIAZABICYCLO[2.2.1]HEPT-2-EN-5-YL}HEPT-6-ENOIC ACID
Diseases
GWAS
Protein-protein Interactions		3 interactors: APP PTGS1 PTGS2
Entrez ID		5740
HPRD ID		09046
Ensembl ID		ENSG00000124212
Uniprot IDs		Q16647
PDB IDs		2IAG 3B6H
Enriched GO Terms of Interacting Partners?		Cyclooxygenase Pathway Prostaglandin Biosynthetic Process Prostaglandin Metabolic Process Response To Oxidative Stress Icosanoid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Arachidonic Acid Metabolic Process Icosanoid Metabolic Process Unsaturated Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Learning Maintenance Of Blood-brain Barrier Lipid Metabolic Process Regulation Of Blood Pressure Defense Response Synaptic Growth At Neuromuscular Junction Positive Regulation Of Fibroblast Growth Factor Production Collateral Sprouting In Absence Of Injury Learning Or Memory Cognition Positive Regulation Of Platelet-derived Growth Factor Production Negative Regulation Of Synaptic Transmission, Dopaminergic Nicotinamide Metabolic Process Blood Circulation Fatty Acid Metabolic Process Collateral Sprouting Axon Midline Choice Point Recognition Response To Light Stimulus Positive Regulation Of Brown Fat Cell Differentiation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Axon Choice Point Recognition Positive Regulation Of Prostaglandin Biosynthetic Process Inflammatory Response Small Molecule Metabolic Process Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Synaptic Plasticity Response To Radiation Single-organism Behavior Neuron Remodeling Cellular Response To ATP Response To Fructose Positive Regulation Of Fever Generation Regulation Of Cellular Ketone Metabolic Process Alkaloid Metabolic Process Regulation Of Fever Generation Positive Regulation Of Heat Generation Lipoxygenase Pathway
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