EIF2AK2 and DICER1

Number of citations of the paper that reports this interaction (PubMedID 21903422)
55

Data Source:
BioGRID (affinity chromatography technology, pull down)

		EIF2AK2	DICER1
Description		eukaryotic translation initiation factor 2 alpha kinase 2	dicer 1, ribonuclease III
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Ribosome Membrane Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Cytosol RISC Complex Perinuclear Region Of Cytoplasm Extracellular Exosome RISC-loading Complex
	Molecular Function	Nucleotide Binding RNA Binding Double-stranded RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Phosphatase Regulator Activity Identical Protein Binding Protein Serine Kinase Activity	Nucleotide Binding Nucleic Acid Binding RNA Binding Double-stranded RNA Binding Helicase Activity Nuclease Activity Endonuclease Activity RNA Endonuclease Activity Ribonuclease III Activity Deoxyribonuclease I Activity Protein Binding ATP Binding Hydrolase Activity RNA Endonuclease Activity Producing 5'-phosphomonoesters, Hydrolytic Mechanism Protein Domain Specific Binding SiRNA Binding Metal Ion Binding Regulatory RNA Binding Pre-miRNA Binding
	Biological Process	Positive Regulation Of Cytokine Production Immune System Process Translation Translational Initiation Regulation Of Translational Initiation Protein Phosphorylation Negative Regulation Of Cell Population Proliferation Response To Virus Negative Regulation Of Translation Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Chemokine Production Positive Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Osteoblast Proliferation Cellular Response To Amino Acid Starvation Response To Interferon-alpha Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Viral Genome Replication Innate Immune Response Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Antiviral Innate Immune Response Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of Hematopoietic Stem Cell Proliferation Regulation Of Hematopoietic Stem Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic DNA Fragmentation RNA Processing MiRNA Metabolic Process Negative Regulation Of Schwann Cell Proliferation Negative Regulation Of Gene Expression Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Schwann Cell Differentiation TRNA Decay Post-transcriptional Gene Silencing Nerve Development SiRNA Processing Regulatory NcRNA-mediated Gene Silencing Pre-miRNA Processing Positive Regulation Of Myelination Peripheral Nervous System Myelin Formation Negative Regulation Of Tumor Necrosis Factor Production MiRNA Processing Neuron Projection Morphogenesis Regulation Of Multicellular Organismal Process RISC Complex Assembly Global Gene Silencing By MRNA Cleavage
Pathways		ISG15 antiviral mechanism Inhibition of PKR SUMOylation of immune response proteins Interferon alpha/beta signaling Evasion by RSV of host interferon responses PKR-mediated signaling	MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis M-decay: degradation of maternal mRNAs by maternally stored factors Regulation of MITF-M-dependent genes involved in apoptosis
Drugs		Indomethacin H-89 Fostamatinib
Diseases
GWAS		Glucose homeostasis traits ( 25524916) Platelet count ( 32888494)	Body mass index ( 25760438) Body mass index (dietary energy interaction) ( 23192594) Chin dimples ( 27182965) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Heel bone mineral density ( 28869591 30598549) Metabolite levels ( 23823483) Nose size ( 27182965) Plasma anti-thyroid peroxidase levels ( 29678681) Response to statin therapy ( 20339536)
Interacting Genes		131 interacting genes: ADARB1 CAPRIN1 CASP3 CASP7 CASP8 CDC42 CHUK DHX58 DICER1 DNAJC3 EDC4 EIF2A EIF2S1 EIF6 ELF2 FTSJ3 H2AC20 H2AC4 HSP90AA1 HSPA1A IKBKB IL7R ILF2 ILF3 JAK1 LINC00624 MAP2K6 MAP3K5 MAP3K7 MAVS METAP2 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NCK1 NEIL3 NFKBIA NPM1 OGT PA2G4 PDGFRB PPP1CA PPP1CC PPP2R5A PRKRA PRKRIP1 PTGES3 RAC1 RPL18 SPIDR STAT1 STAT3 STRBP SUMO1 TAB2 TARBP2 THAP12 TIRAP TP53 TYK2 UBE2I ZNF346	12 interacting genes: AGO1 AGO2 ALOX5 DHX58 EIF2AK2 PIWIL1 PIWIL2 PIWIL4 PRKAB2 PRKRA TARBP2 TRIM25
Entrez ID		5610	23405
HPRD ID		01468	05875
Ensembl ID		ENSG00000055332	ENSG00000100697
Uniprot IDs		A0A7P0Z4M0 P19525 Q8IW76	H0YJZ6 Q9UPY3
PDB IDs		1QU6 2A19 2A1A 3UIU 6D3K 6D3L 7OBK 7OBL 8BI7 8I9J 8IZN	2EB1 4NGB 4NGC 4NGD 4NGF 4NGG 4NH3 4NH5 4NH6 4NHA 4WYQ 5ZAK 5ZAL 5ZAM 7XW2 7XW3
Enriched GO Terms of Interacting Partners?		RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Metabolic Process Negative Regulation Of Translation Extracellular Vesicle Regulation Of Translation Negative Regulation Of Cytokine Production Negative Regulation Of Cell Migration Regulation Of Cytokine Production MRNA Destabilization Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cell Motility RNA Destabilization Negative Regulation Of Protein Metabolic Process Negative Regulation Of Locomotion Regulation Of Angiogenesis Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Vasculature Development Negative Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of MRNA Metabolic Process Regulation Of MRNA Stability Regulation Of Cell Migration Regulation Of RNA Stability Regulation Of Protein Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Cell Motility Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Locomotion Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Developmental Process	Double-stranded RNA Binding Regulatory NcRNA-mediated Gene Silencing RISC-loading Complex RISC Complex Assembly RNA Endonuclease Activity Pre-miRNA Processing RNA Binding Regulation Of Translation Negative Regulation Of Gene Expression MiRNA Processing PiRNA Binding SiRNA Processing Post-transcriptional Gene Silencing Single-stranded RNA Binding Post-transcriptional Regulation Of Gene Expression SiRNA Binding Antiviral Innate Immune Response PiRNA Processing P Granule RISC Complex Regulatory NcRNA-mediated Heterochromatin Formation Transposable Element Silencing By Heterochromatin Formation RNA Processing MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Secondary PiRNA Processing Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA Binding Positive Regulation Of MRNA Metabolic Process Transposable Element Silencing PiRNA-mediated Gene Silencing By MRNA Destabilization SiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Metabolic Process Transposable Element Silencing By PiRNA-mediated Heterochromatin Formation Dense Body Negative Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of MRNA Stability Constitutive Heterochromatin Formation Protein-RNA Complex Assembly Negative Regulation Of Metabolic Process Regulation Of RNA Stability Pre-miRNA Binding Endonuclease Activity Cytoplasm Regulation Of Protein Metabolic Process
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