EIF2AK2 and PRKRIP1

Number of citations of the paper that reports this interaction (PubMedID 12679338)
0

Data Source:
HPRD (in vitro, in vivo)

		EIF2AK2	PRKRIP1
Description		eukaryotic translation initiation factor 2 alpha kinase 2	PRKR interacting protein 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Ribosome Membrane Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Extracellular Exosome
	Molecular Function	Nucleotide Binding RNA Binding Double-stranded RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Phosphatase Regulator Activity Identical Protein Binding Protein Serine Kinase Activity	Double-stranded RNA Binding Protein Kinase Inhibitor Activity Protein Binding Protein Kinase Binding
	Biological Process	Positive Regulation Of Cytokine Production Immune System Process Translation Translational Initiation Regulation Of Translational Initiation Protein Phosphorylation Negative Regulation Of Cell Population Proliferation Response To Virus Negative Regulation Of Translation Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Chemokine Production Positive Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Osteoblast Proliferation Cellular Response To Amino Acid Starvation Response To Interferon-alpha Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Viral Genome Replication Innate Immune Response Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Antiviral Innate Immune Response Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of Hematopoietic Stem Cell Proliferation Regulation Of Hematopoietic Stem Cell Differentiation	Renal System Process MRNA Processing RNA Splicing
Pathways		ISG15 antiviral mechanism Inhibition of PKR SUMOylation of immune response proteins Interferon alpha/beta signaling Evasion by RSV of host interferon responses PKR-mediated signaling	mRNA Splicing - Major Pathway
Drugs		Indomethacin H-89 Fostamatinib
Diseases
GWAS		Glucose homeostasis traits ( 25524916) Platelet count ( 32888494)
Interacting Genes		131 interacting genes: ADARB1 CAPRIN1 CASP3 CASP7 CASP8 CDC42 CHUK DHX58 DICER1 DNAJC3 EDC4 EIF2A EIF2S1 EIF6 ELF2 FTSJ3 H2AC20 H2AC4 HSP90AA1 HSPA1A IKBKB IL7R ILF2 ILF3 JAK1 LINC00624 MAP2K6 MAP3K5 MAP3K7 MAVS METAP2 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NCK1 NEIL3 NFKBIA NPM1 OGT PA2G4 PDGFRB PPP1CA PPP1CC PPP2R5A PRKRA PRKRIP1 PTGES3 RAC1 RPL18 SPIDR STAT1 STAT3 STRBP SUMO1 TAB2 TARBP2 THAP12 TIRAP TP53 TYK2 UBE2I ZNF346	7 interacting genes: APP CEBPA CEP70 EIF2AK2 GSK3B MAGEA11 TRAF2
Entrez ID		5610	79706
HPRD ID		01468	11460
Ensembl ID		ENSG00000055332	ENSG00000128563
Uniprot IDs		A0A7P0Z4M0 P19525 Q8IW76	Q9H875
PDB IDs		1QU6 2A19 2A1A 3UIU 6D3K 6D3L 7OBK 7OBL 8BI7 8I9J 8IZN	5XJC 6ICZ 6QDV 7W5A 7W5B 8C6J 9FMD
Enriched GO Terms of Interacting Partners?		RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Metabolic Process Negative Regulation Of Translation Extracellular Vesicle Regulation Of Translation Negative Regulation Of Cytokine Production Negative Regulation Of Cell Migration Regulation Of Cytokine Production MRNA Destabilization Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cell Motility RNA Destabilization Negative Regulation Of Protein Metabolic Process Negative Regulation Of Locomotion Regulation Of Angiogenesis Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Vasculature Development Negative Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of MRNA Metabolic Process Regulation Of MRNA Stability Regulation Of Cell Migration Regulation Of RNA Stability Regulation Of Protein Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Cell Motility Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Locomotion Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Developmental Process	Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Gene Expression Response To Peptide Response To Cytokine Regulation Of Hematopoietic Stem Cell Proliferation TORC2 Signaling Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Response To Endoplasmic Reticulum Stress Regulation Of Protein Metabolic Process Negative Regulation Of Metabolic Process Neuron Projection Organization Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Protein Localization To Nucleus Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of DNA-templated Transcription Intracellular Signaling Cassette Regulation Of RNA Biosynthetic Process Cellular Response To Amyloid-beta Identical Protein Binding Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of RNA Metabolic Process Regulation Of Translation Positive Regulation Of Chemokine Production Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Amylin Binding Response To Amyloid-beta Regulation Of Proteolysis Positive Regulation Of Toll Signaling Pathway Regulation Of Protein Catabolic Process Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Apoptotic Signaling Pathway RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Stem Cell Differentiation Regulation Of Microtubule Anchoring At Centrosome Translational Initiation Positive Regulation Of NF-kappaB Transcription Factor Activity TORC2 Complex Disassembly Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process TOR Signaling Regulation Of Protein-containing Complex Assembly Regulation Of Stem Cell Proliferation Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction
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