EIF2AK2 and PRKRIP1

Number of citations of the paper that reports this interaction (PMID 12679338)
3

Data Source:
HPRD (in vivo, in vitro)

		EIF2AK2	PRKRIP1
Gene Name		eukaryotic translation initiation factor 2-alpha kinase 2	PRKR interacting protein 1 (IL11 inducible)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Ribosome Membrane Perinuclear Region Of Cytoplasm	Nucleolus Extracellular Vesicular Exosome
	Molecular Function	Double-stranded RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Phosphatase Type 2A Regulator Activity Poly(A) RNA Binding	Double-stranded RNA Binding Protein Kinase Inhibitor Activity Protein Kinase Binding
	Biological Process	Activation Of MAPKK Activity Positive Regulation Of Cytokine Production Transcription, DNA-templated Translation Protein Phosphorylation Negative Regulation Of Cell Proliferation Response To Virus Negative Regulation Of Translation Peptidyl-tyrosine Phosphorylation Modulation By Virus Of Host Morphology Or Physiology Modulation By Virus Of Host Process Viral Life Cycle Evasion Or Tolerance By Virus Of Host Immune Response Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Chemokine Production Positive Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Osteoblast Proliferation Response To Interferon-alpha Negative Regulation Of Apoptotic Process Negative Regulation Of Viral Genome Replication Innate Immune Response Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of Hematopoietic Stem Cell Proliferation Regulation Of Hematopoietic Stem Cell Differentiation	Renal System Process Negative Regulation Of Protein Kinase Activity Negative Regulation Of Phosphorylation
Pathways		ISG15 antiviral mechanism Interferon Signaling Inhibition of PKR Cytokine Signaling in Immune system Host Interactions with Influenza Factors Influenza Infection NS1 Mediated Effects on Host Pathways Antiviral mechanism by IFN-stimulated genes
Drugs
Diseases
GWAS
Protein-Protein Interactions		48 interactors: CASP3 CASP7 CASP8 CDC42 CHUK DHX30 DHX58 DHX9 DICER1 DNAJC3 EDC4 EIF2S1 EIF6 ELF2 FTSJ3 HIST2H2AC HSP90AA1 HSPA1A IKBKB IL7R ILF2 ILF3 JAK1 MAP3K5 MAP3K7 METAP2 MOV10 NFKBIA NPM1 PDGFRB PPP1CA PPP1CC PPP2R5A PRKRA PRKRIP1 PRKRIR PTGES3 RAC1 STAT1 STAT3 STRBP TAB2 TARBP2 TIRAP TOLLIP TP53 TYK2 ZNF346	5 interactors: APP CEP70 EIF2AK2 MAGEA11 TRAF2
Entrez ID		5610	79706
HPRD ID		01468	11460
Ensembl ID		ENSG00000055332	ENSG00000128563
Uniprot IDs		B7ZKK7 P19525 Q8IW76	Q9H875
PDB IDs		1QU6 2A19 2A1A 3UIU
Enriched GO Terms of Interacting Partners?		Immune Response Defense Response Immune System Process Innate Immune Response Response To Stress Response To Organic Substance Cellular Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Regulation Of Immune System Process Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Metabolic Process Response To Stimulus Regulation Of Cell Death Response To External Stimulus Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Cellular Response To Stimulus Regulation Of Apoptotic Process Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Fc Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Signal Transduction Toll-like Receptor 4 Signaling Pathway Regulation Of Cellular Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Posttranscriptional Regulation Of Gene Expression Cellular Response To Growth Factor Stimulus Response To Biotic Stimulus Response To Abiotic Stimulus Signaling Response To Growth Factor Response To Virus Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor Signaling Pathway Toll-like Receptor 2 Signaling Pathway Cell Communication Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Kinase Activity TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Metabolic Process Response To DsRNA Positive Regulation Of Intracellular Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway	Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of NIK/NF-kappaB Signaling Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Innate Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Evasion Or Tolerance By Virus Of Host Immune Response Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Protein Binding Positive Regulation Of Peptidase Activity Synaptic Growth At Neuromuscular Junction Regulation Of Hematopoietic Stem Cell Differentiation Regulation Of Stress-activated MAPK Cascade Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Collateral Sprouting In Absence Of Injury Evasion Or Tolerance Of Host Defenses By Virus Positive Regulation Of Protein Metabolic Process Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation Immune Response Regulation Of Phosphorylation Defense Response Regulation Of Binding Activation Of Protein Kinase Activity Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Hematopoietic Stem Cell Proliferation Regulation Of Translation Positive Regulation Of Proteolysis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Phosphorus Metabolic Process Positive Regulation Of Catalytic Activity Axon Choice Point Recognition Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Host Immune Response Positive Regulation Of Cytokine Production Regulation Of NLRP3 Inflammasome Complex Assembly Neuron Remodeling Regulation Of Endopeptidase Activity Positive Regulation Of Protein Homodimerization Activity Regulation Of Peptidase Activity Regulation Of Translational Initiation In Response To Stress Cellular Response To Nitric Oxide Response To Oxidative Stress Negative Regulation Of Osteoblast Proliferation Positive Regulation Of MAPK Cascade Regulation Of Immunoglobulin Secretion
Tagcloud ?		c1qdc1 cds1 crebbp ctnnd1 cul1 customized dner eef2 fzd2 fzd9 g93a gastrocnemius id2 inppl1 keep loxl2 neuromuscular pi3 pik3c2a pik4ca piki3r1 precede presymptomatic prkx rac3 ripk4 snf1lk sod1 tbl1x
Tagcloud (Difference) ?		c1qdc1 cds1 crebbp ctnnd1 cul1 customized dner eef2 fzd2 fzd9 g93a gastrocnemius id2 inppl1 keep loxl2 neuromuscular pi3 pik3c2a pik4ca piki3r1 precede presymptomatic prkx rac3 ripk4 snf1lk sod1 tbl1x
Tagcloud (Intersection) ?